An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis

참고문헌 (172)

1. Dixon, S. J., "Ferroptosis : an iron-dependent form of nonapoptotic cell death", Cell, 149, pp.1060~1072 (2012)
2. Yang, W. S., "Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis", Proc. Natl Acad. Sci. USA, 113, pp.E4966~E4975 (2016)
3. Stockwell, B. R., "Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications", Cell, 185, pp.2401~2421 (2022)
4. Niki, E., "Lipid peroxidation : physiological levels and dual biological effects", Free Radic. Biol. Med, 47, pp.469~484 (2009)
5. Negre-Salvayre, A., "Pathological aspects of lipid peroxidation", Free Radic. Res, 44, pp.1125~1171 (2010)
6. Wenzel, S. E., "PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals", Cell, 171, pp.628~641 (2017)
7. Anthonymuthu, T. S., "Resolving the paradox of ferroptotic cell death : ferrostatin-1 binds to 15LOX", PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis, 2021, pp.38, 101744~
8. Conrad, M., "The chemical basis of ferroptosis", Nat. Chem. Biol, 15, pp.1137~1147 (2019)
9. Chu, B., "ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway", Nat. Cell Biol, 21, pp.579~591 (2019)
10. Shah, R., "Resolving the role of lipoxygenases in the initiation and execution of ferroptosis", ACS Cent. Sci, 4, pp.387~396 (2018)
11. Zou, Y., "Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis", Nat. Chem. Biol, 16, pp.302~309 (2020)
12. Yan, B., "Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1", Mol. Cell (2020)
13. van Kuijk, F. J. G. M., "Consecutive action of phospholipase A2 and glutathione peroxidase is required for reduction of phospholipid hydroperoxides and provides a convenient method to determine peroxide values in membranes", J. Free Radic. Biol. Med, 1, pp.421~427 (1985)
14. Yang, W. S., "Regulation of ferroptotic cancer cell death by GPX4", Cell, 156, pp.317~331 (2014)
15. Ursini, F., "The selenoenzyme phospholipid hydroperoxide glutathione peroxidase", Biochim. Biophys. Acta Gen. Subj, 839, pp.62~70 (1985)
16. Hassannia, B., "Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma", J. Clin. Invest, 128, pp.3341~3355 (2018)
17. Zilka, O., "On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death", ACS Cent. Sci, 3, pp.232~243 (2017)
18. Yant, L. J., "The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults", Free Radic. Biol. Med, 34, pp.496~502 (2003)
19. Seiler, A., "Glutathione peroxidase 4 senses and translates oxidative stress into 12", 15-lipoxygenase dependent-and AIF-Mediated cell death, 2008, pp.8, 237~248
20. Friedmann Angeli, J. P., "Inactivation of the ferroptosis regulator Gpx4triggers acute renal failure in mice", Nat. Cell Biol, 16, pp.1180~1191 (2014)
21. Bersuker, K., "The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis", Nature, 575, pp.688~692 (2019)
22. Xie, Y., "The tumor suppressor p53 limits ferroptosis by blocking DPP4activity", Cell Rep, 20, pp.1692~1704 (2017)
23. Bannai, S., "Effect of antioxidants on cultured human diploid fibroblasts exposed to cystine-free medium", Biochem. Bioph. Res. Commun, 74, pp.1582~1588 (1977)
24. Shah, R., "The potency of diarylamine radical-trapping antioxidants as inhibitors of ferroptosis underscores the role of autoxidation in the mechanism of cell death", ACS Chem. Biol, 12, pp.2538~2545 (2017)
25. Doll, S., "FSP1 is a glutathione-independent ferroptosis suppressor", Nature, 575, pp.693~698 (2019)
26. Koppula, P., "A targetable CoQ-FSP1 axis drives ferroptosis-and radiationresistance in KEAP1 inactive lung cancers", Nat. Commun, 13, pp.2206~ (2022)
27. Mishima, E., "A non-canonical vitamin K cycle is a potent ferroptosis suppressor", Nature, 608, pp.778~783 (2022)
28. Jin, D. -Y., "A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase", Nat. Commun, 14, pp.828~ (2023)
29. Gan, B., "Mitochondrial regulation of ferroptosis", J. Cell Biol, 220, pp.e202105043~ (2021)
30. Gao, M., "Role of mitochondria in ferroptosis", Mol. Cell, 73, pp.354~363 (2019)
31. Schaar, C. E., "Mitochondrial and cytoplasmic ROS have opposing effects on lifespan", PLoS Genet, 11, pp.e1004972~ (2015)
32. Dan Dunn, J., "Reactive oxygen species and mitochondria : a nexus of cellular homeostasis", Redox Biol, 6, pp.472~485 (2015)
33. Gao, M., "Glutaminolysis and transferrin regulate ferroptosis", Mol. Cell, 59, pp.298~308 (2015)
34. Ahola, S., "OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy", Cell Metab, 34, pp.1875~1891 (2022)
35. Liang, D., "Ferroptosis at the intersection of lipid metabolism and cellular signaling", Mol. Cell, 82, pp.2215~2227 (2022)
36. Christophersen, B. O., "The inhibitory effect of reduced glutathione on the lipid peroxidation of the microsomal fraction and mitochondria", Biochem. J, 106, pp.515~522 (1968)
37. Witting, L. A., "The effect of antioxidant deficiency on tissue lipid composition in the rat. IV. Peroxidation and interconversion of polyunsaturated fatty acids in muscle phospholipids", Lipids, 2, pp.109~113 (1967)
38. Kagan, V. E., "Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis", Nat. Chem. Biol, 13, pp.81~90 (2017)
39. Beharier, O., "PLA2G6 guards placental trophoblasts against ferroptotic injury", Proc. Natl Acad. Sci. USA, 117, pp.27319~27328 (2020)
40. Kapralov, A. A., "Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death", Nat. Chem. Biol, 16, pp.278~290 (2020)
41. Alli, A. A., "Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis", Clin. Immunol, 248, pp.109213~ (2022)
42. Miao, Z., "Hsp90 induces Acsl4-dependent glioma ferroptosis via dephosphorylating Ser637 at Drp1", Cell Death Dis, 13, pp.548~ (2022)
43. Wiernicki, B., "Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis", Cell Death Dis, 11, pp.922~ (2020)
44. O’Donnell, V. B., "New appreciation for an old pathway : the Lands Cycle moves into new arenas in health and disease", Biochem. Soc. T, 50, pp.1~11 (2022)
45. Moessinger, C., "Two different pathways of phosphatidylcholine synthesis, the Kennedy Pathway and the Lands Cycle, differentially regulate cellular triacylglycerol storage", BMC Cell Biol, 15, pp.43~ (2014)
46. Hill, E. E., "Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine", BBA-Lipid Lipid Met, 152, pp.645~648 (1968)
47. Astudillo, A. M., "Compartmentalized regulation of lipid signaling in oxidative stress and inflammation : plasmalogens, oxidized lipids and ferroptosis as new paradigms of bioactive lipid research", Prog. Lipid Res, 89, pp.101207~ (2023)
48. Snaebjornsson, M. T., "Greasing the wheels of the cancer machine : the role of lipid metabolism in cancer", Cell Metab, 31, pp.62~76 (2020)
49. Alves, A. Q., "The fatty acid composition of vegetable oils and their potential use in wound care", Adv. Skin. Wound Care, 32, pp.1~8 (2019)
50. Hu, Q., "New insight into the evolution of volatile profiles in four vegetable oils with different saturations during thermal processing by integrated volatolomics and lipidomics analysis", Food Chem, 403, pp.134342~ (2023)
51. Lee, J. Y., "Lipid metabolism and ferroptosis", Biology (Basel), 10, pp.184~ (2021)
52. Kang, M. J., "A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis", Proc. Natl Acad. Sci. USA, 94, pp.2880~2884 (1997)
53. Hishikawa, D., "Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity", Proc. Natl Acad. Sci. USA, 105, pp.2830~2835 (2008)
54. Hashidate-Yoshida, T., "Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport", Elife, 4, pp.e06328~ (2015)
55. Doll, S., "ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition", Nat. Chem. Biol, 13, pp.91~98 (2017)
56. Dixon, S. J., "Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death", ACS Chem. Biol, 10, pp.1604~1609 (2015)
57. Lin, Z., "The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis", Nat. Commun, 13, pp.7965~ (2022)
58. Liao, P., "CD8(+)T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4", Cancer Cell, 40, pp.365~378 (2022)
59. Magtanong, L., "Context-dependent regulation of ferroptosis sensitivity", Cell Chem. Biol, 29, pp.1409~1418 (2022)
60. Bartolacci, C., "Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer", Nat. Commun, 13, pp.4327~ (2022)
61. Reed, A., "LPCAT3 inhibitors remodel the polyunsaturated phospholipid content of human cells and protect from ferroptosis", ACS Chem. Biol, 17, pp.1607~1618 (2022)
62. Lee, J. Y., "Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer", Proc. Natl Acad. Sci. USA, 117, pp.32433~32442 (2020)
63. Nigam, S., "Phospholipase A2s and lipid peroxidation", Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1488, pp.167~181 (2000)
64. Muralikrishna Adibhatla, R., "Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia", Free Radic. Biol. Med, 40, pp.376~387 (2006)
65. Chen, D., "iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4", Nat. Commun, 12, pp.3644~ (2021)
66. Sun, W. Y., "Phospholipase iPLA2beta averts ferroptosis by eliminating a redox lipid death signal", Nat. Chem. Biol, 17, pp.465~476 (2021)
67. Lu, B., "Identification of PRDX6 as a regulator of ferroptosis", Acta Pharmacol. Sin, 40, pp.1334~1342 (2019)
68. Fras, Z., "On the present and future role of Lp-PLA(2)in atherosclerosis-related cardiovascular risk prediction and management", Arch. Med. Sci, 17, pp.954~964 (2021)
69. Luo, X., "Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2", Cell Death Differ, 28, pp.1971~1989 (2021)
70. Oh, M., "Darapladib, an inhibitor of Lp-PLA2, sensitizes cancer cells to ferroptosis by remodeling lipid metabolism. 2023.2004.2008.536136", ~ (2023)
71. Kamphorst, J. J., "Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids", Proc. Natl Acad. Sci. USA, 110, pp.8882~8887 (2013)
72. Young, A. J., "Blood fatty acid changes in healthy young Americans in response to a 10-week diet that increased n-3 and reduced n-6 fatty acid consumption : a randomised controlled trial", Br. J. Nutr, 117, pp.1257~1269 (2017)
73. Gallego, S. F., "Total fatty acid analysis of human blood samples in one minute by high-resolution mass spectrometry", Biomolecules, 9, pp.7~ (2019)
74. Abdelmagid, S. A., "Comprehensive profiling of plasma fatty acid concentrations in young healthy Canadian adults", PLoS One, 10, pp.e0116195~ (2015)
75. Rodencal, J., "A tale of two lipids : lipid unsaturation commands ferroptosis sensitivity", Proteomics, 23, pp.e2100308~ (2022)
76. Yamane, D., "FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication", Cell Chem. Biol, 29, pp.799~810 (2022)
77. Vriens, K., "Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity", Nature, 566, pp.403~406 (2019)
78. Perez, M. A., "Dietary lipids induce ferroptosis in caenorhabditiselegans and human cancer cells", Dev. Cell, 54, pp.447~454 (2020)
79. Lorito, N., "FADS1", 2-mediated lipid metabolic reprogramming drives ferroptosis sensitivity in triple-negative breast cancer, 2023
80. Kato, A., "Acsl1 is essential for skin barrier function through the activation of linoleic acid and biosynthesis of ω-O-acylceramide in mice", BBA-Mol. Cell Biol. L, 1867, pp.159085~ (2022)
81. Grevengoed, T. J., "Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function", J. Lipid Res, 56, pp.1572~1582 (2015)
82. Beatty, A., "Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1", Nat. Commun, 12, pp.2244~ (2021)
83. von Krusenstiern, A. N., "Identification of essential sites of lipid peroxidation in ferroptosis", Nat. Chem. Biol, 19, pp.719~730 (2023)
84. Mbah, N. E., "Metabolic regulation of ferroptosis in the tumor microenvironment", J. Biol. Chem, 298, pp.101617~ (2022)
85. Zheng, J., "The metabolic underpinnings of ferroptosis", Cell Metab, 32, pp.920~937 (2020)
86. Kim, M. J, "Metabolic regulation of ferroptosis in cancer", Biol. (Basel), 10, pp.83~ (2021)
87. Linkermann, A., "Synchronized renal tubular cell death involves ferroptosis", Proc. Natl Acad. Sci. USA, 111, pp.16836~16841 (2014)
88. Lee, H., "Energy-stress-mediated AMPK activation inhibits ferroptosis", Nat. Cell Biol, 22, pp.225~234 (2020)
89. Song, X., "PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis", Cell Rep, 34, pp.108767~ (2021)
90. Aldrovandi, M., "Juggling with lipids, a game of Russian roulette", Trends Endocrinol. Metab, 32, pp.463~473 (2021)
91. Alba, N., "Region specific vulnerability to lipid peroxidation in the human central nervous system", pp.437~456 (2012), Lipid peroxidation InTech
92. Oh, J. E., "Deciphering fatty acid synthase inhibition-triggered metabolic flexibility in prostate cancer cells through untargeted metabolomics", Cells, 9, pp.2447~ (2020)
93. Spitz, D. R., "The effect of monosaturated and polyunsaturated fatty acids on oxygen toxicity in cultured cells", Pediatr. Res, 32, pp.366~372 (1992)
94. Magtanong, L., "Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state", Cell Chem. Biol, 26, pp.420~432 (2019)
95. Ubellacker, J. M., "Lymph protects metastasizing melanoma cells from ferroptosis", Nature, 585, pp.113~118 (2020)
96. Fisher, E. A., "Complexity in the secretory pathway : the assembly and secretion of apolipoprotein B-containing lipoproteins", J. Biol. Chem, 277, pp.17377~17380 (2002)
97. Liang, D., "Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones", Cell, 186, pp.2748~2764 (2023)
98. Soula, M., "Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers", Nat. Chem. Biol, 16, pp.1351~1360 (2020)
99. Tesfay, L., "Stearoyl-CoA desaturase 1 protects ovarian cancer cells from ferroptotic cell death", Cancer Res, 79, pp.5355~5366 (2019)
100. Luis, G., "Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1(SCD1)in cancer cells and Fatty Acid Biding Protein-4(FABP4)in tumor microenvironment promote tumor recurrence", Redox Biol, 43, pp.102006~ (2021)
101. Yi, J., "Oncogenic activation of PI3KAKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis", Proc. Natl Acad. Sci. USA, 117, pp.31189~31197 (2020)
102. Qin, S., "Early-life vitamin B12 orchestrates lipid peroxidation to ensure reproductive success via SBP-1", SREBP1 in Caenorhabditis elegans, 2022, pp.40, 111381~
103. Fernández, L. P., "Alterations of lipid metabolism in cancer : implications in prognosis and treatment", Front. Oncol, 10, pp.577420~577420 (2020)
104. Pascual, G., "Targeting metastasis-initiating cells through the fatty acid receptor CD36", Nature, 541, pp.41~45 (2017)
105. Hangauer, M. J., "Drug-tolerant persister cancer cells are vulnerable to GPX4inhibition", Nature, 551, pp.247~250 (2017)
106. Tousignant, K. D., "Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer", Cancer Metab, 8, pp.11~ (2020)
107. Abumrad, N., "Membrane proteins implicated in longchain fatty acid uptake by mammalian cells : CD36, FATP and FABPm", Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1441, pp.4~13 (1999)
108. Glatz, J. F. C., "Membrane fatty acid transporters as regulators of lipid metabolism : implications for metabolic disease", Physiol. Rev, 90, pp.367~417 (2010)
109. Watt, M. J., "Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer", Sci. Transl. Med, 11, pp.eaau5758~ (2019)
110. Tumeh, P. C., "PD-1 blockade induces responses by inhibiting adaptive immune resistance", Nature, 515, pp.568~571 (2014)
111. Ma, X., "CD36-mediated ferroptosis dampens intratumoral CD8(+) T cell effector function and impairs their antitumor ability", Cell Metab, 33, pp.1001~1012 (2021)
112. Kim, R., "Ferroptosis of tumour neutrophils causes immune suppression in cancer", Nature, 612, pp.338~346 (2022)
113. Wang, W., "CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy", Nature, 569, pp.270~274 (2019)
114. Jiang, Z., "TYRO3 induces anti-PD-1", PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis, 2021, pp.131, e139434~
115. Xu, H., "Ferroptosis in the tumor microenvironment : perspectives for immunotherapy", Trends Mol. Med, 27, pp.856~867 (2021)
116. Xu, C., "The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity", Cell Rep, 35, pp.109235~ (2021)
117. Olzmann, J. A., "Dynamics and functions of lipid droplets", Nat. Rev. Mol. Cell Biol, 20, pp.137~155 (2019)
118. Lee, J., "Lipid metabolism alterations and ferroptosis in cancer: Paving the way for solving cancer resistance", Eur. J. Pharmacol, 941, pp.175497~ (2023)
119. Zou, Y., "A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis", Nat. Commun, 10, pp.1617~ (2019)
120. Zhang, Y., "Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model", Cell Chem. Biol, 26, pp.623~633 (2019)
121. Klasson, T. D., "ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma", Cancer Metab, 10, pp.14~ (2022)
122. Dierge, E., "Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects", Cell Metab, 33, pp.1701~1715 (2021)
123. Zielinski, Z. A. M., "Cholesterol autoxidation revisited : debunking the dogma associated with the most vilified of lipids", J. Am. Chem. Soc, 138, pp.6932~6935 (2016)
124. Thomas, J. P., "Enzymatic reduction of phospholipid and cholesterol hydroperoxides in artificial bilayers and lipoproteins", BBA-Lipid Lipid Met, 1045, pp.252~260 (1990)
125. Tang, D., "Ferroptosis : molecular mechanisms and health implications", Cell Res, 31, pp.107~125 (2021)
126. Friedmann Angeli, J. P., "Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion", Nat. Rev. Cancer, 19, pp.405~414 (2019)
127. Sec lacking isopentenyladenosine, "J. Biol. Chem", 2000, 28110~28119
128. Shimada, K., "Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis", Nat. Chem. Biol, 12, pp.497~503 (2016)
129. Mao, C., "DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer", Nature, 593, pp.586~590 (2021)
130. Garcia-Bermudez, J., "Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death", Nature, 567, pp.118~122 (2019)
131. Hong, X., "The lipogenic regulator SREBP2 induces transferrin in circulating melanoma cells and suppresses ferroptosis", Cancer Discov, 11, pp.678~695 (2021)
132. Rink, J. S., "Targeted reduction of cholesterol uptake in cholesterol-addicted lymphoma cells blocks turnover of oxidized lipids to cause ferroptosis", J. Biol. Chem, 296, pp.100100~ (2021)
133. Zou, Y., "Plasticity of ether lipids promotes ferroptosis susceptibility and evasion", Nature, 585, pp.603~608 (2020)
134. Cui, W., "Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis", Cell Death Differ, 28, pp.2536~2551 (2021)
135. Lee, J. -Y., "A new way to create ether lipids", Nat. Chem. Biol, 19, pp.259~260 (2023)
136. Reed, A., "TMEM164 is an acyltransferase that forms ferroptotic C20 : 4 ether phospholipids", Nat. Chem. Biol, 19, pp.378~388 (2023)
137. Bebber, C. M., "Ferroptosis response segregates small cell lung cancer(SCLC)neuroendocrine subtypes", Nat. Commun, 12, pp.2048~ (2021)
138. Mahoney-Sanchez, L., "Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition", Cell Rep, 40, pp.111231~ (2022)
139. Dean, J. M, "Structural and functional roles of ether lipids", Protein Cell, 9, pp.196~206 (2018)
140. Zhang, S., "Double-edge sword roles of iron in driving energy production versus instigating ferroptosis", Cell Death Dis, 13, pp.40~ (2022)
141. Ayton, S., "Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology", Mol. Psychiatry, 25, pp.2932~2941 (2020)
142. Greenough, M. A., "Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations", Cell Death Differ, 29, pp.2123~2136 (2022)
143. Ayton, S., "Deferiprone to delay dementia(the 3D trial)", Alzheimer’s Dement, 16, pp.e044107~ (2020)
144. Jakaria, M., "Ferroptosis as a mechanism of neurodegeneration in Alzheimer’s disease", J. Neurochem, 159, pp.804~825 (2021)
145. Ryan, S. K., "Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration", Nat. Neurosci, 26, pp.12~26 (2023)
146. Mahoney-Sánchez, L., "Ferroptosis and its potential role in the physiopathology of Parkinson’s Disease", Prog. Neurobiol, 196, pp.101890~ (2021)
147. Tonnus, W., "Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury", Nat. Commun, 12, pp.4402~ (2021)
148. Wang, Y., "ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury", Redox Biol, 51, pp.102262~ (2022)
149. Fang, X., "Ferroptosis as a target for protection against cardiomyopathy", Proc. Natl Acad. Sci. USA, 116, pp.2672~2680 (2019)
150. Park, T. J., "Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes", Cell Death Dis, 10, pp.835~ (2019)
151. Fratta Pasini, A. M., "New Insights into the role of ferroptosis in cardiovascular diseases", Cells, 12, pp.867~ (2023)
152. Conrad, M., "Broken hearts : iron overload, ferroptosis and cardiomyopathy", Cell Res, 29, pp.263~264 (2019)
153. Bai, T., "Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell", Free Radic. Biol. Med, 160, pp.92~102 (2020)
154. Tan, S., "Oxytosis : a novel form of programmed cell death", Curr. Top. Med. Chem, 1, pp.497~506 (2001)
155. Ni, L., "Targeting ferroptosis in acute kidney injury", Cell Death Dis, 13, pp.182~ (2022)
156. Abe, K., "Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis", Sci. Signal, 15, pp.eabn8017~ (2022)
157. Van Coillie, S., "Targeting ferroptosis protects against experimental(multi)organ dysfunction and death", Nat. Commun, 13, pp.1046~ (2022)
158. Bao, W. D., "Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease", Cell Death Differ, 28, pp.1548~1562 (2021)
159. Pedrera, L., "Ferroptotic pores induce Ca(2+)fluxes and ESCRT-III activation to modulate cell death kinetics", Cell Death Differ, 28, pp.1644~1657 (2021)
160. Dai, E., "ESCRT-III-dependent membrane repair blocks ferroptosis", Biochem. Bioph. Res. Commun, 522, pp.415~421 (2020)
161. Xiang Qian, "The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights", Experimental and Molecular Medicine, 54, pp.1~9 (2022), 생화학분자생물학회[DOI]
162. Sun, X., "Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells", Hepatology, 63, pp.173~184 (2016)
163. Dodson, M., "NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis", Redox Biol, 23, pp.101107~ (2019)
164. Kim Il-Young, "Tracing metabolic flux in vivo: basic model structures of tracer methodology", Experimental and Molecular Medicine, 54, pp.1~12 (2022), 생화학분자생물학회[DOI]
165. Salvador Amadeo F., "Measurement of lipid flux to advance translational research: evolution of classic methods to the future of precision health", Experimental and Molecular Medicine, 54, pp.1~6 (2022), 생화학분자생물학회[DOI]
166. Bae Hosung, "Metabolic flux between organs measured by arteriovenous metabolite gradients", Experimental and Molecular Medicine, 54, pp.1~13 (2022), 생화학분자생물학회[DOI]
167. Chi Thi Ngoc Nguyen, "Mass spectrometry-based approaches to explore metabolism regulating ferroptosis", BMB Reports, 55(9), pp.413~416 (2022), 생화학분자생물학회
168. Chen, X., "Iron metabolism in ferroptosis", Front. Cell Dev. Biol, 8, pp.590226~ (2020)
169. Conlon, M., "A compendium of kinetic modulatory profiles identifies ferroptosis regulators", Nat. Chem. Biol, 17, pp.665~674 (2021)
170. Rodriguez, R., "Persister cancer cells : Iron addiction and vulnerability to ferroptosis", Mol. Cell, 82, pp.728~740 (2022)
171. Lei, G., "Targeting ferroptosis as a vulnerability in cancer", Nat. Rev. Cancer, 22, pp.381~396 (2022)
172. Hassannia, B., "Targeting ferroptosis to iron out cancer", Cancer Cell, 35, pp.830~849 (2019)

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