본문 바로가기
KERD
논문KCI 등재

새로운 non-apoptotic 세포사멸: ferroptosis

Novel non-apoptotic cell death: ferroptosis

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류의학일반

초록

Ferroptosis is a newly recognized type of cell death that results from iron-dependent lipid peroxidation and is different from other types of cell death, such as apoptosis, necrosis, and autophagic cell death. This type of cell death is characterized by mitochondrial shrinkage with an increased mitochondrial membrane density and outer mitochondrial membrane rupture. Ferroptosis can be induced by a loss of activity of system Xc - and the inhibition of glutathione peroxidase 4, followed by the accumulation of lipid reactive oxygen species (ROS). In addition, inactivation of the mevalonate and transsulfuration pathways is involved in the induction of ferroptosis. Moreover, nicotinamide adenine dinucleotide phosphate oxidase and p53 promote ferroptosis by increasing ROS production, while heat shock protein beta-1 and nuclear factor erythroid 2-related factor 2 inhibit ferroptosis by reducing iron uptake. This article outlines the molecular mechanisms and signaling pathways of ferroptosis regulation, and explains the roles of ferroptosis in human disease

Abstract

Ferroptosis is a newly recognized type of cell death that results from iron-dependent lipid peroxidation and is different from other types of cell death, such as apoptosis, necrosis, and autophagic cell death. This type of cell death is characterized by mitochondrial shrinkage with an increased mitochondrial membrane density and outer mitochondrial membrane rupture. Ferroptosis can be induced by a loss of activity of system Xc - and the inhibition of glutathione peroxidase 4, followed by the accumulation of lipid reactive oxygen species (ROS). In addition, inactivation of the mevalonate and transsulfuration pathways is involved in the induction of ferroptosis. Moreover, nicotinamide adenine dinucleotide phosphate oxidase and p53 promote ferroptosis by increasing ROS production, while heat shock protein beta-1 and nuclear factor erythroid 2-related factor 2 inhibit ferroptosis by reducing iron uptake. This article outlines the molecular mechanisms and signaling pathways of ferroptosis regulation, and explains the roles of ferroptosis in human disease

참고문헌 (65)

  1. Dixon SJ, "Ferroptosis: an iron-dependent form of nonapoptotic cell death", Cell, 149, pp.1060~1072 (2012)
  2. Bogdan AR, "Regulators of iron homeostasis: new players in metabolism, cell death, and disease", Trends Biochem Sci, 41, pp.274~286 (2016)
  3. Manz DH, "Iron and cancer: recent insights", Ann N Y Acad Sci, 1368, pp.149~161 (2016)
  4. Pratt DA, "Free radical oxidation of polyunsaturated lipids: new mechanistic insights and the development of peroxyl radical clocks", Acc Chem Res, 44, pp.458~467 (2011)
  5. Ray PD, "Reactive oxygen species (ROS)homeostasis and redox regulation in cellular signaling", Cell Signal, 24, pp.981~990 (2012)
  6. Dolma S, "Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells", Cancer Cell, 3, pp.285~296 (2003)
  7. Yang WS, "Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells", Chem Biol, 15, pp.234~245 (2008)
  8. Leist M, "Four deaths and a funeral: from caspases to alternative mechanisms", Nat Rev Mol Cell Biol, 2, pp.589~598 (2001)
  9. Saraste A, "Morphologic and biochemical hallmarks of apoptosis", Cardiovasc Res, 45, pp.528~537 (2000)
  10. Yu X, "The role of necroptosis, an alternative form of cell death, in cancer therapy", Expert Rev Anticancer Ther, 13, pp.883~893 (2013)
  11. Xie Y, "Ferroptosis:process and function", Cell Death Differ, 23, pp.369~379 (2016)
  12. Bridges RJ, "System Xc - cystine", glutamate antiporter: an update on molecular pharmacology and roles within the CNS, 2012, pp.165, 20~34
  13. Bannai S, "Effect of antioxidants on cultured human diploid fibroblasts exposed to cystine-free medium", Biochem Biophys Res Commun, 74, pp.1582~1588 (1977)
  14. Yang WS, "Regulation of ferroptotic cancer cell death by GPX4", Cell, 156, pp.317~331 (2014)
  15. Yagoda N, "RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels", Nature, 447, pp.864~868 (2007)
  16. Brigelius-Flohé R, "Glutathione peroxidases", Biochim Biophys Acta, 1830, pp.3289~3303 (2013)
  17. Dixon SJ, "Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis", Elife, 3, pp.e02523~ (2014)
  18. Lachaier E, "Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors", Anticancer Res, 34, pp.6417~6422 (2014)
  19. Louandre C, "Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib", Int J Cancer, 133, pp.1732~1742 (2013)
  20. Gao M, "Glutaminolysis and transferrin regulate ferroptosis", Mol Cell, 59, pp.298~308 (2015)
  21. Mehta A, "Excitotoxicity: bridge to various triggers in neurodegenerative disorders", Eur J Pharmacol, 698, pp.6~18 (2013)
  22. Wolpaw AJ, "Modulatory profiling identifies mechanisms of small molecule-induced cell death", Proc Natl Acad Sci U S A, 108, pp.E771~E780 (2011)
  23. Tan S, "Oxytosis: a novel form of programmed cell death", Curr Top Med Chem, 1, pp.497~506 (2001)
  24. Dixon SJ, "The role of iron and reactive oxygen species in cell death", Nat Chem Biol, 10, pp.9~17 (2014)
  25. Ursini F, "Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides", Biochim Biophys Acta, 710, pp.197~211 (1982)
  26. Thomas JP, "Enzymatic reduction of phospholipid and cholesterol hydroperoxides in artificial bilayers and lipoproteins", Biochim Biophys Acta, 1045, pp.252~260 (1990)
  27. Weïwer M, "Development of small-molecule probes that selectively kill cells induced to express mutant RAS", Bioorg Med Chem Lett, 22, pp.1822~1826 (2012)
  28. Shimada K, "Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis", Nat Chem Biol, 12, pp.497~503 (2016)
  29. Ursini F, "Diversity of glutathione peroxidases", Methods Enzymol, 252, pp.38~53 (1995)
  30. Maldonado EN, "Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin", J Biol Chem, 288, pp.11920~11929 (2013)
  31. Craigen WJ, "Genetic strategies for dissecting mammalian and Drosophila voltage-dependent anion channel functions", J Bioenerg Biomembr, 40, pp.207~212 (2008)
  32. Graham BH, "Genetic approaches to analyzing mitochondrial outer membrane permeability", Curr Top Dev Biol, 59, pp.87~118 (2004)
  33. Bauer AJ, "Functional model of metabolite gating by human voltage-dependent anion channel 2", Biochemistry, 50, pp.3408~3410 (2011)
  34. Jiang L, "Ferroptosis as a p53-mediated activity during tumour suppression", Nature, 520, pp.57~62 (2015)
  35. Jiang L, "Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses", Cell Cycle, 14, pp.2881~2885 (2015)
  36. Brown KM, "Selenium, selenoproteins and human health: a review", Public Health Nutr, 4, pp.593~599 (2001)
  37. Yant LJ, "The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults", Free Radic Biol Med, 34, pp.496~502 (2003)
  38. Kryukov GV, "Characterization of mammalian selenoproteomes", Science, 300, pp.1439~1443 (2003)
  39. Sec lacking isopentenyladenosine, "J Biol Chem", 2000, 28110~28119
  40. Yang WS, "Ferroptosis: death by lipid peroxidation", Trends Cell Biol, 26, pp.165~176 (2016)
  41. McBean GJ, "The transsulfuration pathway: a source of cysteine for glutathione in astrocytes", Amino Acids, 42, pp.199~205 (2012)
  42. Hayano M, "Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation", Cell Death Differ, 23, pp.270~278 (2016)
  43. Carver JA, "Small heat-shock proteins and clusterin: intra- and extracellular molecular chaperones with a common mechanism of action and function?", IUBMB Life, 55, pp.661~668 (2003)
  44. Jakob U, "Small heat shock proteins are molecular chaperones", J Biol Chem, 268, pp.1517~1520 (1993)
  45. Wu C, "Heat shock transcription factors: structure and regulation", Annu Rev Cell Dev Biol, 11, pp.441~469 (1995)
  46. Sun X, "HSPB1as a novel regulator of ferroptotic cancer cell death", Oncogene, 34, pp.5617~5625 (2015)
  47. Kerins MJ, "The roles of NRF2 in modulating cellular iron homeostasis", Antioxid Redox Signal (2017)
  48. Sun X, "Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells", Hepatology, 63, pp.173~184 (2016)
  49. Kwon MY, "Heme oxygenase-1accelerates erastin-induced ferroptotic cell death", Oncotarget, 6, pp.24393~24403 (2015)
  50. Ross CA, "Huntington's disease: from molecular pathogenesis to clinical treatment", Lancet Neurol, 10, pp.83~98 (2011)
  51. Johnson WM, "Dysregulation of glutathione homeostasis in neurodegenerative diseases", Nutrients, 4, pp.1399~1440 (2012)
  52. Inder T, "Elevated free radical products in the cerebrospinal fluid of VLBW infants with cerebral white matter injury", Pediatr Res, 52, pp.213~218 (2002)
  53. Back SA, "Maturation-de pendent vulnerability of oligodendrocytes to oxidative stressinduced death caused by glutathione depletion", J Neurosci, 18, pp.6241~6253 (1998)
  54. Lőrincz T, "Ferroptosis is involved in acetaminophen induced cell death", Pathol Oncol Res, 21, pp.1115~1121 (2015)
  55. Friedmann Angeli JP, "Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice", Nat Cell Biol, 16, pp.1180~1191 (2014)
  56. Linkermann A, "Synchronized renal tubular cell death involves ferroptosis", Proc Natl Acad Sci U S A, 111, pp.16836~16841 (2014)
  57. Tickoo SK, "Colloidal iron staining in renal epithelial neoplasms, including chromophobe renal cell carcinoma: emphasis on technique and patterns of staining", Am J Surg Pathol, 22, pp.419~424 (1998)
  58. Wilhelm S, "Discovery and development of sorafenib: a multikinase inhibitor for treating cancer", Nat Rev Drug Discov, 5, pp.835~844 (2006)
  59. Ooko E, "Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells", Phytomedicine, 22, pp.1045~1054 (2015)
  60. Eling N, "Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells", Oncoscience, 2, pp.517~532 (2015)
  61. Iglehart JK, "Cystine requirement of continuous human lymphoid cell lines of normal and leukemic origin", J Biol Chem, 252, pp.7184~7191 (1977)
  62. Gout PW, "Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)-cystine transporter: a new action for an old drug", Leukemia, 15, pp.1633~1640 (2001)
  63. Chen L, "Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function", Oncol Rep, 33, pp.1465~1474 (2015)
  64. Yamaguchi H, "Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in nonsmall cell lung cancer cells", Clin Cancer Res, 19, pp.845~854 (2013)
  65. Yu Y, "The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents", Mol Cell Oncol, 2, pp.e1054549~ (2015)

관련 논문AI추천

이 간행물의 다른 논문 (24건)