Mass spectrometry-based approaches to explore metabolism regulating ferroptosis
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초록
Ferroptosis is a type of programmed cell death distinct fromapoptosis or necroptosis. Ferroptosis is well characterized byan iron-dependent accumulation of lipid peroxides and disruptionof cellular membrane integrity. Many metabolic alterationscan prevent or accelerate ferroptosis induction. Recent advancesin analytical techniques of mass spectrometry have allowedhigh-throughput analysis of metabolites known to be criticalfor understanding ferroptosis regulatory metabolism. In this review,we introduce mass spectrometry-based analytical methodscontributing to recent discovery of various metabolic pathwaysregulating ferroptosis, focusing on cysteine metabolism, antioxidantmetabolism, and poly-unsaturated fatty acid metabolism. [
Abstract
Ferroptosis is a type of programmed cell death distinct fromapoptosis or necroptosis. Ferroptosis is well characterized byan iron-dependent accumulation of lipid peroxides and disruptionof cellular membrane integrity. Many metabolic alterationscan prevent or accelerate ferroptosis induction. Recent advancesin analytical techniques of mass spectrometry have allowedhigh-throughput analysis of metabolites known to be criticalfor understanding ferroptosis regulatory metabolism. In this review,we introduce mass spectrometry-based analytical methodscontributing to recent discovery of various metabolic pathwaysregulating ferroptosis, focusing on cysteine metabolism, antioxidantmetabolism, and poly-unsaturated fatty acid metabolism. [
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