일부공단지역에 거주하는 성인남성의 알레르기 반응과 산화손상에 대한 연구
The relationship between allergic responses and oxidative stress among male adults in an industrial area
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Allergic diseases have been dramatically increased over recent years, especially in industrialized countries. Oxidative stress has been believed to play a significant role in the occurrence of the allergic inflammatory responses. Although previous studies concerning oxidative stress and systemic inflammation have been reported, few data is available, and other allergic diseases, except for asthma, are hardly studied about the association with oxidative stress. This study evaluated the relationship between allergic disease and Malondialdehyde (MDA) as an indicator of oxidative stress. The study population was 197 male adults living in an industrial area. The ISAAC questionnaire was used to confirm wheezing and rhinitis, and atopy was evaluated by skin prick test. MDA was analyzed by spectrophotometer. To examine bronchial hyperresponsiveness (BHR), methacholine test was performed, and the index of bronchial responsiveness (BR index) was calculated. We used multivariate logistic regression model and general linear model with SAS program. We found significant associations of MDA with brindex (p=0.023), rhinitis (p=0.016), atopy (p=0.03), adjusted by age, smoking, and body mass index (BMI). On the contrary, there was no significant difference of MDA with the status of asthma. Our result suggests that oxidative stress may play a major role in the occurrence of allergic response in male adults.
Abstract
Allergic diseases have been dramatically increased over recent years, especially in industrialized countries. Oxidative stress has been believed to play a significant role in the occurrence of the allergic inflammatory responses. Although previous studies concerning oxidative stress and systemic inflammation have been reported, few data is available, and other allergic diseases, except for asthma, are hardly studied about the association with oxidative stress. This study evaluated the relationship between allergic disease and Malondialdehyde (MDA) as an indicator of oxidative stress. The study population was 197 male adults living in an industrial area. The ISAAC questionnaire was used to confirm wheezing and rhinitis, and atopy was evaluated by skin prick test. MDA was analyzed by spectrophotometer. To examine bronchial hyperresponsiveness (BHR), methacholine test was performed, and the index of bronchial responsiveness (BR index) was calculated. We used multivariate logistic regression model and general linear model with SAS program. We found significant associations of MDA with brindex (p=0.023), rhinitis (p=0.016), atopy (p=0.03), adjusted by age, smoking, and body mass index (BMI). On the contrary, there was no significant difference of MDA with the status of asthma. Our result suggests that oxidative stress may play a major role in the occurrence of allergic response in male adults.
참고문헌 (37)
- Bonay, M., "Air pollution and allergic airway diseases", Medical Science, 23(2), pp.187~192 (2007)
- Salvi, S., "Pollution and allergic airways disease", Current Opinion in Allergy and Clinical Immunology, 1(1), pp.35~41 (2001)
- Jakab, G. J., "Respiratory aflatoxicosis: suppression of pulmonary and Systemic Host Defenses", Toxicology and Applied Pharmacology, 125(2), pp.198~205 (1994)
- Seo, W. H., "Concentaration of air pollutants and asthma in Taejon City", Korean Journal of Environmental Health, 26(2), pp.80~90 (2000)
- 문경환, "실내 공기 중 일부 알데하이드류에 대한 위해도 평가-일부 주택 및 아토피 환자 주택을 대상으로", 한국환경보건학회지, 32(1), pp.19~26 (2006), 한국환경보건학회
- Animal Health Trust, Park, L., "The role of oxidative stress in an equine model of human Asthma", Communications in Free Radical Research, 11(2), pp.46~52 (2006)
- Russell, P., "Oxidative stress in allergic respiratory diseases", The Journal of Allergy and Clinical Immunology, 110(3), pp.349~356 (2002)
- Ryoung-Me Ahn, "Effects of natural extracts on COX-1 and COX-2 mRNA expression on UVB-induced skin inflammation in C57BL", 6 mouse, 2006, pp.32(6), 566~570[DOI]
- Nickel, R., "MAS-Study group. : Association study of Glutathione-S-transferase P1(GSTP1) with asthma and bronchial hyper-responsiveness in two German pediatric populations", Pediatric allergy and immunology : official publication of the EuropeanSociety of Pediatric Allergy and Immunology, 16, pp.539~541 (2005)
- Ercan, H., "Oxidative stress and genetic and epidemiologic determinants of oxidant injury in childhood asthma", The Journal of Allergy and Clinical Immunology, 118(5), pp.1097~1104 (2006)
- Chung, Y. S., "Polymorphism at the glutathione S-transferase P1 locus in Korean patients with perennial allergic rhinitis", American Journal of Rhinology, 20(6), pp.648~651 (2006)
- Atambay, M., "Nilgundaldal. Dust-mites:Effect on lipid peroxidation", The National Medicaal Journal of India, 19(2), pp.73~75 (2006)
- Omata, N., "Increased oxidative stress in childhood atopic dermatitis", Basic Life Sciences, 69, pp.223~228 (2001)
- Nadeem, A., "Increased oxidative stress and altered levels of antioxidants in asthma", The Journal of Allergy and Clinical Immunology, 111(1), pp.72~78 (2003)
- Mel, E., "Influence of male sex and parental allergic disease on childhood wheezing: role of interactions", Clinical and Experimental Allergy, 34(6), pp.839~844 (2004)
- Shaheen, S. O., "Maternal testosterone in pregnancy and atopic outcomes in childhood", Allergy, 62(1), pp.25~32 (2007)
- Mrenschlager, M., "The course of eczema in children aged 57 years and its relation to atopy: differences between boys and girls", British Journal of Dermatology, 154(3), pp.505~513 (2006)
- Lykkesfeldt, J., "Malondialdehyde as biomarker of oxidative damage to lipids caused by smoking", Clinica Chimica Acta; International Journal of Clinical Chemistry, 380(1-2), pp.50~58 (2007)
- Martin, J., "Asthma, Airway Biology, and Allergic Rhinitis in AJRCCM2000", American Journal of Respiratory and Critical Care Medicine, 164, pp.1559~1580 (2001)
- Corradi, M., "Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease", American Journal of Respiratory and Critical Care Medicine, 167, pp.1380~1386 (2003)
- Boutin-Forzano, S., "Air pollution and atopy", European Annals of Allergy and Clinical Immunology, 37(1), pp.11~16 (2005)
- Sorensen, M., "Personal PM2.5 exposure and markers of oxidative stress in blood", Environmental Health Perspectives, 111(2), pp.161~166 (2003)
- Lee, Y. L., "Associations of FcepsilonRIbeta E237G polymorphism with wheezing in Taiwanese schoolchildren", Clinical and Experimental Allergy, 38(3), pp.413~420 (2008)
- Lee, Y. L., "Environmental factors, parental atopy and atopic eczema in primary-school children: a cross-sectional study in Taiwan", The British Journal of Dermatology, 157(6), pp.1217~1224 (2007)
- Jacobson, G. A., "Elevated plasma glutathione peroxidase concentration in acute severe asthma: comparison with plasma glutathione peroxidase activity, selenium and malondialdehyde", Scandinavian Journal of Clinical and Laboratory Investigation, 67(4), pp.423~430 (2007)
- Cheng, Y. K., "Oxidative stress in nonallergic nasal polps associated with bronchial hyperresponsiveness", Allergy, 61(11), pp.1290~1298 (2006)
- Nielsen, F., "Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors", Clinical Chemistry, 43(7), pp.1209~1214 (1997)
- Calhoun, W. J., "Enhanced superoxide production by alveolar macrophages and air-space cells, airway inflammation, and alveolar macrophage density changes after segmental antigen bronchoprovocation in allergic subjexts", The American Review of Respiratory Disease, 145, pp.317~325 (1992)
- Demoly, P., "IgE produces monocyte superoxide anion release: correlation with CD23 expression. Comparison of patients with asthma, patients with rhinitis, and normal subjects", The Journal of Allergy and Clinical Immunology, 93, pp.108~116 (1994)
- Sanders, S. P., "Spontaneous oxygen radical production at sites of antigen challenge in allergic subjects", American Journal of Respiratory and Critical Care Medicine, 151, pp.1725~1733 (1995)
- Vachier, I., "Enhancement of reactive oxygen species formation in stable and unstable asthmatic patients", The European respiratory journal : official journal of the EuropeanSociety for Clinical Respiratory Physiology, 7, pp.1585~1592 (1994)
- Baraldi, E., "Increased exhaled 8-isoprostane in childhood asthma", Chest, 124(1), pp.25~31 (2003)
- Foresi, A., "Eosinophils, mast cells, and basophils in induced sputum from patients with seasonal allergic rhinitis and perennial asthma: relationship to methacholine responsiveness", The Journal of Allergy and Clinical Immunology, 100(1), pp.58~64 (1997)
- Cuttitta, G., "Non-specific bronchial hyper-responsiveness in children with allergic rhinitis: Relationship with the atopic status", Pediatric allergy and immunology : official publication of the EuropeanSociety of Pediatric Allergy and Immunology, 14(6), pp.458~463 (2003)
- Okayama, Y., "Oxidative stress in allergic and inflammatory skin diseases", Current drug targets. Inflammation and Allergy, 4(4), pp.517~519 (2005)
- Spiteri, M. A., "Polymorphisms at the glutathione S-transferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation", Allergy, 55, pp.15~20 (2000)
- Wright, R. J., "The impact of stress on the development and expression of atopy", Current Opinion in Allergy and Clinical Immunology, 5(1), pp.23~29 (2005)