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Chloromethylisothiazolinone (CMIT)과 Methylisothiazolinone (MIT)의 건강영향에 대한 고찰 - 가습기 살균제 폐 손상을 중심으로 -

Review of Health Effects Caused by Chloromethylisothiazolinone (CMIT) and Methylisothiazolinone (MIT) - Focusing on Humidifier Disinfectant-associated Lung Injury (HDLI) -

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초록

Objective: This study aimed to summarize the physiochemical properties, toxicity, and legal regulation ofchloromethylisothiazolinone (CMIT) and/or methylisothiazolinone (MIT), review the health effects caused by exposure to CMIT/MIT, and evaluate the individual association of lung injury with the use of humidifier disinfectants (HD) containing a mixture of CMIT and MIT. Method: A literature review was conducted by searching keywords such as CMIT, MIT, health effect, dermatitis, asthma, and lung injury, either singly or combined. Results: Both CMIT and/or MIT were found to be associated with the development of several types of adverse health effects. In particular, respiratory diseases including asthma, nasal symptoms, cough, and rhinitis were caused by the use of products including CMIT or/and MIT. The mixture of CMIT/MIT has been banned in cosmetics. As of the end of 2017, nine patients who were confirmed to have HD associated lung injury (HDLI) were found to have used only an HD brand containing CMIT and MIT. Their responses regarding the name of the HD used could be trustworthy based on the short duration of HD use (less than six months) before the onset of HDLI and frequent use of HD per day. Conclusion: According to the toxicity and HDLI cases, the use of HD containing CMIT and /or MIT can cause fatal lung injury. Further study with manufacturers’ assistance is necessary in order to obtain more clear evidence on the causal relationship since HDLI cases are being reported continuously.

Abstract

Objective: This study aimed to summarize the physiochemical properties, toxicity, and legal regulation ofchloromethylisothiazolinone (CMIT) and/or methylisothiazolinone (MIT), review the health effects caused by exposure to CMIT/MIT, and evaluate the individual association of lung injury with the use of humidifier disinfectants (HD) containing a mixture of CMIT and MIT. Method: A literature review was conducted by searching keywords such as CMIT, MIT, health effect, dermatitis, asthma, and lung injury, either singly or combined. Results: Both CMIT and/or MIT were found to be associated with the development of several types of adverse health effects. In particular, respiratory diseases including asthma, nasal symptoms, cough, and rhinitis were caused by the use of products including CMIT or/and MIT. The mixture of CMIT/MIT has been banned in cosmetics. As of the end of 2017, nine patients who were confirmed to have HD associated lung injury (HDLI) were found to have used only an HD brand containing CMIT and MIT. Their responses regarding the name of the HD used could be trustworthy based on the short duration of HD use (less than six months) before the onset of HDLI and frequent use of HD per day. Conclusion: According to the toxicity and HDLI cases, the use of HD containing CMIT and /or MIT can cause fatal lung injury. Further study with manufacturers’ assistance is necessary in order to obtain more clear evidence on the causal relationship since HDLI cases are being reported continuously.

참고문헌 (49)

  1. Aerts O, "Contact allergy caused by isothiazolinone derivatives : an overview of non-cosmetic and unusual cosmetic sources", Euro J Dermatol, 27(2), pp.115~122 (2017)
  2. Bohn S, "Airborne contact dermatitis from methylchloroisothiazolinone in wall paint. Abolition of symptoms by chemical allergen inactivation", Contact Derm, 42(4), pp.196~201 (2000)
  3. "Substance Infocard" (2020)[URL]
  4. Special Committee for Examining the Cause of Tragedy caused by Humidifier Disinfectant (SCECTHD), "Analysis of components of disinfectant contained in humidifier disinfectant products", ~ (2020)
  5. "COMMISSION REGULATION (EU) No 1003/2014 of 18 September 2014amending Annex V to Regulation (EC) No 1223/2009 of the European Parliament and of the Council on Cosmetic Products Off J Eur Union" (2014)[URL]
  6. "Regulation on cosmetic safety standards and etc. (being enforced since February 2020). Official Notification No. 2020-12" (2020)[URL]
  7. "Eleventh Commission Directive 89/174/EEC of 21 February 1989 adapting to technical progress Annexes II, III, IV, V, VI and VII to Council Directive 76/768/EEC on the approximation of the laws of the Member States relating to cosmetic products (89/174/EEC). Off J Eur Union" (1989)[URL]
  8. "Opinion on methylisothiazolinone (P94) submission II (sensitisation only). Revison of 27 March, 2014 (No. SCCS/1521/13)" (2014)[URL]
  9. "Council Direct of 27 July 1976 on the approximation of the laws of the Member States relating tocosmetic products (76/768/EEC)" (2010)[URL]
  10. "Occupational exposure limits for chemical and physical agents. Official Notification No. 2018-62" (2020)[URL]
  11. Patel A, "Methylisothiazolinone allergy in the paediatric population: the epidemic begins?", Br J Dermatol, 170(5), pp.1200~1201 (2014)
  12. 김민국, "Risk Assessment of 5-Chloro-2-Methylisothiazol-3(2H)-One", 2-Methylisothiazol-3(2H)-One (CMIT, 한국독성학회지, pp.2019, 35(2)[DOI]
  13. Bourke S, "Occupational asthma in an isothiazolinone manufacturing plant", Thorax, 52(8), pp.746~748 (1997)
  14. He K, "Methylisothiazolinone, a neurotoxic biocide, disrupts the association of SRC family tyrosine kinases with focal adhesion kinase in developing cortical neurons", J Pharmacol Exp Ther, 317(3), pp.1320~1329 (2006)
  15. Yoon J, "Exposure to humidifier disinfectants increases the risk for asthma in children", Am J Respir Crit Care Med, 198(12), pp.1583~1586 (2018)
  16. A study on the characteristics of asthma caused by humidifier disinfectants, "National Institute of Environmental Research", ~ (2019)
  17. "Annex V: Cosmetic ingredient database (Cosing) - List of preservatives allowed in cosmetic products (last update on 23/01/2020)" (2020)[URL]
  18. "Final report on amended safety assessment of methylchloroisothiazolinone and methylisothiazolinone as used in cosmetics" (2019)[URL]
  19. 이소연, "The Pathological Findings of Chloromethylisothiazolinone and Methylisothiazolinone-associated Lung Injury", Journal of Korean Medical Science, 34(14), pp.1~3 (2019), 대한의학회
  20. 이은, "Two Cases of Chloromethylisothiazolinone and Methylisothiazolinone-associated Toxic Lung Injury", Journal of Korean Medical Science, 33(16), pp.1~8 (2018), 대한의학회
  21. Cho HJ, "Effects of a mixture of chloromethylisothiazolinone and methylisothiazolinone on peripheral airway dysfunction in children", PloS One, 12(4), pp.e0176083~ (2017)
  22. Schmidt MG, "Copper continuously limits the concentration of bacteria resident on bed rails within the intensive care unit", Infect Control Hosp Epidemiol, 34(5), pp.530~533 (2013)
  23. Gebhardt M, "Urticaria caused by type IV sensitization to isothiazolinones", Contact Derm, 36(6), pp.314~ (1997)
  24. Maor D, "Allergic contact dermatitis to methylchloroisothiazolinone", methylisothiazolinone in cooling tower technicians, 2015, pp.26(1), 62~64
  25. Isaksson M, "Occupational contact dermatitis caused by methylchloroisothiazolinone", methylisothiazolinone through exposure to filler dust containing this preservative and with a positive patch test reaction to the dust, 2015, pp.73(2), 119~120
  26. Madsen JT, "Undisclosed methylisothiazolinone in an ultrasound gel causing occupational allergic contact dermatitis", Contact Derm, 71(5), pp.312~313 (2014)
  27. Amsler E, "Airborne allergic contact dermatitis caused by isothiazolinones in water-based paints : a retrospective study of 44 cases", Contact Derm, 77(3), pp.163~170 (2017)
  28. Alwan W, "Presumed airborne contact allergy to methylisothiazolinone causing acute severe facial dermatitis and respiratory difficulty", Contact Derm, 70(5), pp.320~321 (2014)
  29. Admani S, "Methylisothiazolinone : a case of perianal dermatitis caused by wet wipes and review of an emerging pediatric allergen", Pediatr Dermatol, 31(3), pp.350~352 (2014)
  30. Van Steenkiste E, "Airborne-induced lymphomatoid contact dermatitis caused by methylisothiazolinone", Contact Derm, 72(4), pp.237~240 (2015)
  31. Lundov MD, "Airborne exposure to methylchloroisothiazolinone and methylisothiazolinone from a toilet cleaner", Contact Derm, 68(4), pp.252~253 (2013)
  32. Lundov MD, "Two cases of airborne allergic contact dermatitis caused by methylisothiazolinone in paint", Contact Derm, 65(3), pp.176~178 (2011)
  33. Fewings J, "An update of the risk assessment for methylchloroisothiazolinone", methylisothiazolinone(MCI, Contact Derm, pp.1999, 41(1)[DOI]
  34. Tosti A, "Prevalence and sources of Kathon CG sensitization in Italy", Contact Derm, 18(3), pp.173~174 (1988)
  35. Aerts O, "The dramatic increase in the rate of methylisothiazolinone contact allergy in Belgium : a multicentre study", Contact Derm, 71(1), pp.41~48 (2014)
  36. Schwensen JF, "Methylisothiazolinone and benzisothiazolinone are widely used in paint : a multicentre study of paints from five E uropean countries", Contact Derm, 72(3), pp.127~138 (2015)
  37. Yazar K, "Methylisothiazolinone in rinse-off products causes allergic contact dermatitis : a repeated open-application study", Br J Dermatol, 173(1), pp.115~122 (2015)
  38. Burnett CL, "Final report of the safety assessment of methylisothiazolinone", Int J Toxicol, 29(4_suppl), pp.187S~213S (2010)
  39. "Scientific Committee on Cosmetic Products and Non-Food Products intended for Consumers. Opinion Concerning Methylisothiazolinone (SCCNFP/0805/04)" (2004)[URL]
  40. "Comprehensive supporting portal for humidifier disinfectant victims: Statistical data"[URL]
  41. 박동욱, "가습기 살균제 피해자 호흡기로 흡입된 가습기 살균제 양 추정 - 호흡기 외부(external) 및 내부 노출(internal exposure) 추정 방법과 사례 -", 한국환경보건학회지, 42(3), pp.141~146 (2016), 한국환경보건학회
  42. Cohn BA, "DDT and breast cancer : prospective study of induction time and susceptibility windows", J Natl Cancer Inst, 111(8), pp.803~810 (2019)
  43. Beard J, "DDT and human health", Sci Total Environ, 355(1-3), pp.78~89 (2006)
  44. Ingber SZ, "DDT", DDE and breast cancer : A meta-analysis, 2013, pp.67(3), 421~433
  45. Hom M, "Systematic review and meta-analysis of testicular germ cell tumors following in utero exposure to diethylstilbestrol", J Natl Cancer Inst Cancer Spectrum, 3(3), pp.pkz045~ (2019)
  46. Titus L, "Reproductive and hormone-related outcomes in women whose mothers were exposed in utero to diethylstilbestrol(DES) : a report from the US National Cancer Institute DES third generation study", Reprod Toxicol, 84, pp.32~38 (2019)
  47. Troisi R, "Prenatal diethylstilbestrol exposure and cancer risk in women", Environ Mol Mutagen, 60(5), pp.395~403 (2019)
  48. Ito T, "Deciphering the mystery of thalidomide teratogenicity", Congenit Anom, 52(1), pp.1~7 (2012)
  49. Kowalski TW, "Thalidomide embryopathy : Followup of cases born between 1959 and 2010", Birth Defects Res A, 103(9), pp.794~803 (2015)

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