Immunomodulatory functional foods and their molecular mechanisms
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The immune system comprises a complex group of processes that provide defense against diverse pathogens. These defenses can be divided into innate and adaptive immunity, in which specific immune components converge to limit infections. In addition to genetic factors, aging, lifestyle, and environmental factors can influence immune function, potentially affecting the susceptibility of the host to disease-causing agents. Chemical compounds in certain foods have been shown to regulate signal transduction and cell phenotypes, ultimately impacting pathophysiology. Research has shown that the consumption of specific functional foods can stimulate the activity of immune cells, providing protection against cancer, viruses, and bacteria. Here, we review a number of functional foods reported to strengthen immunity, including ginseng, mushrooms, chlorella, and probiotics (Lactobacillus plantarum). We also discuss the molecular mechanisms involved in regulating the activity of various types of immune cells. Identifying immune-enhancing functional foods and understanding their mechanisms of action will support new approaches to maintain proper health and combat immunological diseases.
Abstract
The immune system comprises a complex group of processes that provide defense against diverse pathogens. These defenses can be divided into innate and adaptive immunity, in which specific immune components converge to limit infections. In addition to genetic factors, aging, lifestyle, and environmental factors can influence immune function, potentially affecting the susceptibility of the host to disease-causing agents. Chemical compounds in certain foods have been shown to regulate signal transduction and cell phenotypes, ultimately impacting pathophysiology. Research has shown that the consumption of specific functional foods can stimulate the activity of immune cells, providing protection against cancer, viruses, and bacteria. Here, we review a number of functional foods reported to strengthen immunity, including ginseng, mushrooms, chlorella, and probiotics (Lactobacillus plantarum). We also discuss the molecular mechanisms involved in regulating the activity of various types of immune cells. Identifying immune-enhancing functional foods and understanding their mechanisms of action will support new approaches to maintain proper health and combat immunological diseases.
참고문헌 (136)
- Frisch, M., "Association of cancer with AIDS-related immunosuppression in adults", J. Am. Med. Assoc, 285, pp.1736~1745 (2001)
- Rier, S. E., "Environmental immune disruption: a comorbidity factor for reproduction?", Fertil. Steril, 89, pp.e103~e108 (2008)
- Imai, K., "Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence : an 11-year follow-up study of a general population", Lancet, 356, pp.1795~1799 (2000)
- Montecino-Rodriguez, E., "Causes, consequences, and reversal of immune system aging", J. Clin. Invest, 123, pp.958~965 (2013)
- Nakano, Y., "Immune function and lifestyle of taxi drivers in Japan", Ind. Health, 36, pp.32~39 (1998)
- Thorburn, A. N., "Diet, metabolites, and"western-lifestyle"inflammatory diseases", Immunity, 40, pp.833~842 (2014)
- Cava, E., "Obesity pandemic during COVID-19 outbreak : Narrative review and future considerations", Clin. Nutr, 40, pp.1637~1643 (2021)
- Hachimura, S., "Immunomodulation by food : impact on gut immunity and immune cell function", Biosci. Biotechnol. Biochem, 82, pp.584~599 (2018)
- Iwasaki, A., "Innate immunity to influenza virus infection", Nat. Rev. Immunol, 14, pp.315~328 (2014)
- Linehan, E., "Ageing and the immune system : focus on macrophages", Eur. J. Microbiol. Immunol, 5, pp.14~24 (2015)
- Lukacs, N. W., "TNF-alpha mediates recruitment of neutrophils and eosinophils during airway inflammation", J. Immunol, 154, pp.5411~5417 (1995)
- Almishri, W., "TNFalpha augments cytokine-induced NK Cell IFNgamma production through TNFR2", J. Innate Immun, 8, pp.617~629 (2016)
- Sharma, J. N., "Role of nitric oxide in inflammatory diseases", Inflammopharmacology, 15, pp.252~259 (2007)
- Lee, J., "The immunostimulating activity of quercetin 3-O-xyloside in murine macrophages via activation of the ASK1", MAPK, Int. Immunopharmacol, pp.2016, 31[DOI]
- Hirschfeld, M., "Cutting edge : repurification of lipopolysaccharide eliminates signaling through both human and murine tolllike receptor 2", J. Immunol, 165, pp.618~622 (2000)
- Takeuchi, O., "Toll-like receptors; their physiological role and signal transduction system", Int. Immunopharmacol, 1, pp.625~635 (2001)
- Vivier, E., "Natural killer cell signaling pathways", Science, 306, pp.1517~1519 (2004)
- Guermonprez, P., "Antigen presentation and T cell stimulation by dendritic cells", Annu. Rev. Immunol, 20, pp.621~667 (2002)
- Iwasaki, A., "Control of adaptive immunity by the innate immune system", Nat. Immunol, 16, pp.343~353 (2015)
- Hahn, H., "The role of cell-mediated immunity in bacterial infections", Rev. Infect. Dis, 3, pp.1221~1250 (1981)
- Andersen, M. H., "Cytotoxic T cells", J. Invest. Dermatol, 126, pp.32~41 (2006)
- Ekkens, M. J., "Th1 and Th2 cells help CD8 T-cell responses", Infect. Immun, 75, pp.2291~2296 (2007)
- Walker, J. A., "TH2 cell development and function", Nat. Rev. Immunol, 18, pp.121~133 (2018)
- Hyun-Ah Lee, "Dead Lactobacillus plantarum Stimulates and Skews Immune Responses toward T helper 1 and 17 Polarizations in RAW 264.7 Cells and Mouse Splenocytes", Journal of Microbiology and Biotechnology, 26(3), pp.469~476 (2016), 한국미생물·생명공학회[DOI]
- Yu, S. -L., "Immunopathological roles of cytokines, chemokines, signaling molecules, and pattern-recognition receptors in systemic lupus erythematosus", Clin. Dev. Immunol, 2012, pp.715190~ (2012)
- Tan, B. K., "Immunomodulatory and antimicrobial effects of some traditional chinese medicinal herbs: a review", Curr. Med. Chem, 11, pp.1423~1430 (2004)
- Jin, Y., "Effect of white, red and black ginseng on physicochemical properties and ginsenosides", Plant Foods Hum. Nutr, 70, pp.141~145 (2015)
- Zhang, H. M., "Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS", MS-based metabolomics approach, 2012, pp.62, 258~273
- Lee, S. Y., "Chemical constituents and biological activities of the berry of Panax ginseng", J. Med. Plants Res, 4, pp.349~353 (2010)
- Shibata, S., "Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds", J. Korean Med. Sci, 16, pp.S28~S37 (2001)
- 임태규, "White ginseng extract induces immunomodulatory effects via the MKK4-JNK pathway", Food Science and Biotechnology, 25(6), pp.1737~1744 (2016), 한국식품과학회[DOI]
- Jang, H. I., "Wild Panax ginseng (Panax ginseng C.A. Meyer) protects against methotrexate-induced cell regression by enhancing the immune response in RAW 264.7 macrophages", Am. J. Chin. Med, 38, pp.949~960 (2010)
- Um, Y., "Wild simulated ginseng activates mouse macrophage, RAW264.7cells through TRL2", 4-dependent activation of MAPK, NF-kappaB and PI3K, J. Ethnopharmacol, pp.2020, 263[DOI]
- 강수원, "Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System", Journal of Ginseng Research, 36(4), pp.354~368 (2012), 고려인삼학회
- Shen, T., "Polysaccharide from wheat bran induces cytokine expression via the toll-like receptor 4-mediated p38 MAPK signaling pathway and prevents cyclophosphamide-induced immunosuppression in mice", Food Nutr. Res, 61, pp.1344523~ (2017)
- Yang, Y., "Immunostimulatory effects of sulfated chitosans on RAW 264.7mouse macrophages via the activation of PI3K", Akt signaling pathway, 2018, pp.108, 1310~1321
- He, L. X., "Ginseng (Panax ginseng Meyer) oligopeptides regulate innate and adaptive immune responses in mice via increased macrophage phagocytosis capacity, NK cell activity and Th cells secretion", Food Funct, 8, pp.3523~3532 (2017)
- Larsen, M. W., "Ginseng modulates the immune response by induction of interleukin-12 production", APMIS, 112, pp.369~373 (2004)
- 김미형, "Immunomodulatory Activity of Ginsan, a Polysaccharide of Panax Ginseng, on Dendritic Cells", The Korean Journal of Physiology & Pharmacology, 13(3), pp.169~173 (2009), 대한약리학회
- Ahn, J. Y., "The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals.", Eur. J. Immunol, 36, pp.37~45 (2006)
- Song, J. Y., "Induction of secretory and tumoricidal activities in peritoneal macrophages by ginsan", Int. Immunopharmacol, 2, pp.857~865 (2002)
- Takei, M., "Dendritic cells maturation promoted by M1 and M4, end products of steroidal ginseng saponins metabolized in digestive tracts, drive a potent Th1 polarization", Biochem. Pharmacol, 68, pp.441~452 (2004)
- Song, Z., "Cytokine modulating effect of ginseng treatment in a mouse model of Pseudomonas aeruginosa lung infection", J. Cyst. Fibros, 2, pp.112~119 (2003)
- Takeda, K., "Interferon-gamma-mediated natural killer cell activation by an aqueous Panax ginseng extract", Evid. Based Complement. Altern. Med, 2015, pp.603198~ (2015)
- Scaglione, F., "Immunomodulatory effects of two extracts of Panax ginseng C.A. Meyer", A. Meyer. Drugs Exp. Clin. Res, 16, pp.537~542 (1990)
- Kenarova, B., "Immunomodulating activity of ginsenoside Rg1 from Panax ginseng", Jpn. J. Pharmacol, 54, pp.447~454 (1990)
- Kim, J. Y., "Panax ginseng as a potential immunomodulator : studies in mice", Immunopharm. Immunot, 12, pp.257~276 (1990)
- Liou, C. J., "Short-term oral administration of ginseng extract induces type-1 cytokine production", Immunopharm. Immunot, 28, pp.227~240 (2006)
- Liou, C. J., "Intraperitoneal injection of ginseng extract enhances both immunoglobulin and cytokine production in mice", Am. J. Chin. Med, 32, pp.75~88 (2004)
- Qu, D. F., "Ginsenoside Rg1 enhances immune response induced by recombinant Toxoplasma gondii SAG1 antigen", Vet. Parasitol, 179, pp.28~34 (2011)
- 이현철, "Ginsan Enhances Humoral Antibody Response to Orally Delivered Antigen", Immune Network, 10(1), pp.5~14 (2010), 대한면역학회
- Su, X., "Ginsenoside Re as an adjuvant to enhance the immune response to the inactivated rabies virus vaccine in mice", Int. Immunopharmacol, 20, pp.283~289 (2014)
- Seon-Kyu Han, "Ginsan Improved Th1 Immune Response Inhibited by Gamma Radiation", Archives of Pharmacal Research, 28(3), pp.343~350 (2005), 대한약학회
- Lee, E. J., "Ginsenoside Rg1 enhances CD4(+) T-cell activities and modulates Th1", Th2 differentiation, 2004, pp.4, 235~244
- Berek, L., "Effects of naturally occurring glucosides, solasodine glucosides, ginsenosides and parishin derivatives on multidrug resistance of lymphoma cells and leukocyte functions", Vivo, 15, pp.151~156 (2001)
- Lee, J. H., "Ginsenoside Rg1 helps mice resist to disseminated candidiasis by Th1 type differentiation of CD4+ T cell", Int. Immunopharmacol, 6, pp.1424~1430 (2006)
- Rivera, E., "The Rb1fraction of ginseng elicits a balanced Th1 and Th2 immune response", Vaccine, 23, pp.5411~5419 (2005)
- Wang, Y., "A solution with ginseng saponins and selenium as vaccine diluent to increase Th1", Th2 immune responses in mice, 2020, pp.2020, 2714257~
- Peck, A., "Precarious balance : Th17 cells in host defense", Infect. Immun, 78, pp.32~38 (2010)
- Maqbool, B., "Ginseng stem-leaf saponins in combination with selenium enhance immune responses to an attenuated pseudorabies virus vaccine", Microbiol. Immunol, 63, pp.269~279 (2019)
- Cox, J. C., "Adjuvants—a classification and review of their modes of action", Vaccine, 15, pp.248~256 (1997)
- Shin, K. K., "Korean red ginseng plays an anti-aging role by modulating expression of aging-related genes and immune cell subsets", Molecules, 25, pp.1492~ (2020)
- Kim, H., "Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus", H1N1 infection, 2016, pp.68, 406~420
- Byeon, S. E., "Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean red ginseng", Mediat. Inflamm, 2012, pp.732860~ (2012)
- Quan, F. S., "Ginseng and Salviae herbs play a role as immune activators and modulate immune responses during influenza virus infection", Vaccine, 25, pp.272~282 (2007)
- Kwok, H. H., "Anti-inflammatory effects of indirubin derivatives on influenza A virus-infected human pulmonary microvascular endothelial cells", Sci. Rep, 6, pp.18941~ (2016)
- Chan, L. Y., "Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis", J. Ethnopharmacol, 137, pp.1542~1546 (2011)
- Dae-Goon Yoo, "Protective Effect of Korean Red Ginseng Extract on the Infections by H1N1 and H3N2 Influenza Viruses in Mice", Journal of Medicinal Food, 15(10), pp.855~862 (2012), 한국식품영양과학회[DOI]
- Yang, Z., "Ginsenoside Rd elicits Th1 and Th2immune responses to ovalbumin in mice", Vaccine, 25, pp.161~169 (2007)
- Song, X., "Enhancement of immune responses to influenza vaccine(H3N2)by ginsenoside Re", Int. Immunopharmacol, 10, pp.351~356 (2010)
- Su, F., "Ginsenosides Rg1 and Re act as adjuvant via TLR4 signaling pathway", Vaccine, 30, pp.4106~4112 (2012)
- Sun, J., "Ginsenoside Rg1 and aluminum hydroxide synergistically promote immune responses to ovalbumin in BALB", c mice, 2008, pp.15, 303~307
- Bremner, P., "Natural products as targeted modulators of the nuclear factor-kappaB pathway", J. Pharm. Pharmacol, 54, pp.453~472 (2002)
- Sun Hee Hyun, "Immuno-enhancement effects of Korean Red Ginseng in healthy adults: a randomized, double-blind, placebo-controlled trial", Journal of Ginseng Research, 45(1), pp.191~198 (2021), 고려인삼학회[DOI]
- 이창섭, "Preventive Effect of Korean Red Ginseng for Acute Respiratory Illness: A Randomized and Double-Blind Clinical Trial", Journal of Korean Medical Science, 27(12), pp.1472~1478 (2012), 대한의학회
- Mizuno, T., "Bioactive biomolecules of mushrooms—food, function and medicinal effect of mushroom fungi", Food Rev. Int, 11, pp.7~21 (1995)
- Takimoto, H., "Amelioration of skewed Th1", Th2 balance in tumor-bearing and asthma-induced mice by oral administration of Agaricus blazei extracts, 2008, pp.30, 747~760
- Takimoto, H., "Potentiation of cytotoxic activity in naive and tumor-bearing mice by oral administration of hot-water extracts from Agaricus brazei fruiting bodies", Biol. Pharm. Bull, 27, pp.404~406 (2004)
- Lin, J. G., "An extract of Agaricus blazei Murill administered orally promotes immune responses in murine leukemia BALB", c mice in vivo, 2012, pp.11, 29~36
- Val, C. H., "Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria", Malar. J, 14, pp.311~ (2015)
- Guo, L., "Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum", Int. Immunopharmacol, 9, pp.1175~1182 (2009)
- Wang, G., "Enhancement of IL-2 and IFN-gamma expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo", Int. Immunopharmacol, 7, pp.864~870 (2007)
- Wang, P. Y., "Antitumor and immunomodulatory effects of polysaccharides from broken-spore of Ganoderma lucidum", Front. Pharmacol, 3, pp.135~ (2012)
- Gao, Y., "Effects of ganopoly(a Ganoderma lucidum polysaccharide extract)on the immune functions in advanced-stage cancer patients", Immunol. Invest, 32, pp.201~215 (2003)
- Kodama, N., "A polysaccharide, extract from Grifola frondosa, induces Th-1 dominant responses in carcinoma-bearing BALB", c mice, 2002, pp.90, 357~360
- Inoue, A., "Effect of maitake(Grifola frondosa)D-fraction on the control of the T lymph node Th-1", Th-2 proportion, 2002, pp.25, 536~540
- Kodama, N., "Effects of D-Fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells", Biol. Pharm. Bull, 25, pp.1647~1650 (2002)
- Harada, N., "Relationship between dendritic cells and the D-fraction-induced Th-1 dominant response in BALB", c tumor-bearing mice, 2003, pp.192, 181~187
- Noriko Kodama, "Potential Antitumor Activity of a Low-Molecular-Weight Protein Fraction from Grifola frondosa Through Enhancement of Cytokine Production", Journal of Medicinal Food, 13(1), pp.20~30 (2010), 한국식품영양과학회
- Masuda, Y., "Oral administration of soluble beta-glucans extracted from Grifola frondosa induces systemic antitumor immune response and decreases immunosuppression in tumor-bearing mice", Int. J. Cancer, 133, pp.108~119 (2013)
- Masuda, Y., "Inhibitory effect of MD-Fraction on tumor metastasis : involvement of NK cell activation and suppression of intercellular adhesion molecule(ICAM)-1 expression in lung vascular endothelial cells", Biol. Pharm. Bull, 31, pp.1104~1108 (2008)
- Deng, G., "A phase I", II trial of a polysaccharide extract from Grifola frondosa(Maitake mushroom)in breast cancer patients : immunological effects, 2009, pp.135, 1215~1221
- Volman, J. J., "Effects of mushroom-derived beta-glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor-kappaB transactivation in Caco-2 reporter cells: can effects be explained by structure?", Mol. Nutr. Food Res, 54, pp.268~276 (2010)
- Akramiene, D., "Effects of betaglucans on the immune system", Medicines, 43, pp.597~606 (2007)
- Chan, G. C., "The effects of beta-glucan on human immune and cancer cells", J. Hematol. Oncol, 2, pp.25~ (2009)
- 김형숙, "Stimulatory Effect of β-glucans on Immune Cells", Immune Network, 11(4), pp.191~195 (2011), 대한면역학회
- Ashiuchi, M., "Isolation of Bacillus subtilis(chungkookjang), a poly-gammaglutamate producer with high genetic competence", Appl. Microbiol. Biot, 57, pp.764~769 (2001)
- Ahn, H., "Poly-gamma-glutamic acid from Bacillus subtilis upregulates proinflammatory cytokines while inhibiting NLRP3, NLRC4 and AIM2 inflammasome activation", Cell. Mol. Immunol, 15, pp.111~119 (2018)
- Kim, T. W., "Oral administration of high molecular mass poly-gammaglutamate induces NK cell-mediated antitumor immunity", J. Immunol, 179, pp.775~780 (2007)
- Lee, S. W., "Immunomodulatory effect of poly-gamma-glutamic acid derived from Bacillus subtilis on natural killer dendritic cells", Biochem. Biophys. Res. Commun, 443, pp.413~421 (2014)
- Lee, T. Y., "Oral administration of poly-gamma-glutamate induces TLR4-and dendritic cell-dependent antitumor effect", Cancer Immunol. Immunother, 58, pp.1781~1794 (2009)
- Cho, H. W., "Short-term clinical and immunologic effects of poly-gammaglutamic acid(gamma-PGA)in women with cervical intraepithelial neoplasia 1(CIN 1) : a multicenter, randomized, double blind, phase II trial", PLoS ONE, 14, pp.e0217745~ (2019)
- Kim, K. S., "A single-center, randomized double-blind placebo-controlled study evaluating the effects of poly-gamma-glutamate on human NK cell activity after an 8-week oral administration in healthy volunteers", Evid. Based Complement. Altern. Med, 2013, pp.635960~ (2013)
- Kim, E. H., "Intranasal administration of poly-gamma glutamate induced antiviral activity and protective immune responses against H1N1 influenza A virus infection", Virol. J, 12, pp.160~ (2015)
- Rani, K., "A comprehensive review on chlorella-its composition, health benefits, market and regulatory scenario", Pharma Innov. J, 7, pp.584~589 (2018)
- Chakka, S., "The effects of immunostimulatory herbal supplements on autoimmune skin diseases", J. Am. Acad. Dermatol, 84, pp.1051~1058 (2020)
- Cheng, D., "Dietary Chlorella vulgaris ameliorates altered immunomodulatory functions in cyclophosphamide-induced immunosuppressive mice", Nutrients, 9, pp.708~ (2017)
- 안효진, "Effect of Chlorella vulgaris on Immune-enhancement and Cytokine Production in vivo and in vitro", Food Science and Biotechnology, 17(5), pp.953~958 (2008), 한국식품과학회
- Kwak, J. H., "Beneficial immunostimulatory effect of short-term Chlorella supplementation: enhancement of natural killer cell activity and early inflammatory response (randomized, double-blinded, placebo-controlled trial)", Nutr. J, 11, pp.53~ (2012)
- An, B. K., "Effect of dried Chlorella vulgaris and Chlorella growth factor on growth performance, meat qualities and humoral immune responses in broiler chickens", Springe rplus, 5, pp.718~ (2016)
- Kang, H. K., "Effect of various forms of dietary Chlorella supplementation on growth performance, immune characteristics, and intestinal microflora population of broiler chickens", J. Appl. Poult. Res, 22, pp.100~108 (2013)
- Hasegawa, T., "Augmentation of the resistance against Escherichia coli by oral-administration of a hot water extract of Chlorella vulgaris in rats", Int. J. Immunopharmacol, 11, pp.971~976 (1989)
- Hasegawa, T., "Effect of hot water extract of Chlorella vulgaris on cytokine expression patterns in mice with murine acquired immunodeficiency syndrome after infection with Listeria monocytogenes", Immunopharmacology, 35, pp.273~282 (1997)
- Hasegawa, T., "Hot water extracts of Chlorella vulgaris reduce opportunistic infection with Listeria monocytogenes in C57BL", 6 mice infected with LP-BM5murine leukemia viruses, 1995, pp.17, 505~512
- Hasegawa, T., "Toll-like receptor 2 is at least partly involved in the antitumor activity of glycoprotein from Chlorella vulgaris", Int. Immunopharmacol, 2, pp.579~589 (2002)
- Zhuang, X., "A comparison on the preparation of hot water extracts from Chlorella pyrenoidosa (CPEs) and radical scavenging and macrophage activation effects of CPEs", Food Funct, 5, pp.3252~3260 (2014)
- Hsu, H. Y., "Immunostimulatory bioactivity of algal polysaccharides from Chlorella pyrenoidosa activates macrophages via Toll-like receptor 4", J. Agric. Food Chem, 58, pp.927~936 (2010)
- Pugh, N., "Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, aphanizomenon flos-aquae and Chlorella pyrenoidosa", Planta Med, 67, pp.737~742 (2001)
- Halperin, S. A., "Safety and immunoenhancing effect of a Chlorella-derived dietary supplement in healthy adults undergoing influenza vaccination: randomized, double-blind, placebocontrolled trial", Can. Med. Assoc. J, 169, pp.111~117 (2003)
- Masuo Nakano, "Chlorella (Chlorella pyrenoidosa) Supplementation Decreases Dioxin and Increases Immunoglobulin A Concentrations in Breast Milk", Journal of Medicinal Food, 10(1), pp.134~142 (2007), 한국식품영양과학회
- Kanouchi, H., "Dietary effect of Chlorella pyrenoidosa powder on immunoglobulin productivity of Sprague-Dawley rats", J. Jpn. Soc. Food Sci, 48, pp.634~636 (2001)
- Heczko, P., "Critical evaluation of probiotic activity of lactic acid bacteria and their effects", J. Physiol. Pharmacol, 57, pp.5~12 (2006)
- Adams, C., "The probiotic paradox : live and dead cells are biological response modifiers", Nutr. Res. Rev, 23, pp.37~46 (2010)
- 장혜지, "Immune-stimulating Effect of Lactobacillus plantarum Ln1 Isolated from the Traditional Korean Fermented Food, Kimchi", Journal of Microbiology and Biotechnology, 30(6), pp.926~929 (2020), 한국미생물·생명공학회[DOI]
- 정민주, "Heat-Killed Lactobacillus plantarum KCTC 13314BP Enhances Phagocytic Activity and Immunomodulatory Effects via Activation of MAPK and STAT3 Pathways", Journal of Microbiology and Biotechnology, 29(8), pp.1248~1254 (2019), 한국미생물·생명공학회[DOI]
- 이지선, "Micronized and Heat-Treated Lactobacillus plantarum LM1004 Stimulates Host Immune Responses Via the TLR-2", MAPK, Journal of Microbiology and Biotechnology, pp.2019, 29(5)[DOI]
- Wang, J., "Characterization and immunomodulatory activity of an exopolysaccharide produced by Lactobacillus plantarum JLK0142 isolated from fermented dairy tofu", Int. J. Biol. Macromol, 115, pp.985~993 (2018)
- Ren, D. Y., "Two strains of probiotic Lactobacillus enhance immune response and promote naive T cell polarization to Th1", Food Agr. Immunol, 30, pp.281~295 (2019)
- Rigaux, P., "Immunomodulatory properties of Lactobacillus plantarum and its use as a recombinant vaccine against mite allergy", Allergy, 64, pp.406~414 (2009)
- Kawashima, T., "Lactobacillus plantarum strain YU from fermented foods activates Th1 and protective immune responses", Int. Immunopharmacol, 11, pp.2017~2024 (2011)
- Junhua, X., "Effects of Lactobacillus plantarum NCU116 on intestine mucosal immunity in immunosuppressed mice", J. Agr. Food Chem, 63, pp.10914~10920 (2015)
- Kikuchi, Y., "Oral administration of Lactobacillus plantarum strain AYA enhances IgA secretion and provides survival protection against influenza virus infection in mice", PLoS ONE, 9, pp.e86416~ (2014)
- de Vos, P., "Lactobacillus plantarum strains can enhance human mucosal and systemic immunity and prevent non-steroidal anti-inflammatory drug induced reduction in T regulatory cells", Front. Immunol, 8, pp.1000~ (2017)
- Mane, J., "A mixture of Lactobacillus plantarum CECT 7315 and CECT 7316enhances systemic immunity in elderly subjects. A dose-response, double-blind, placebo-controlled, randomized pilot trial", Nutr. Hosp, 26, pp.228~235 (2011)
- Choi, H. S., "Red ginseng acidic polysaccharide (RGAP) in combination with IFN-gamma results in enhanced macrophage function through activation of the NF-kappaB pathway", Biosci. Biotechnol. Biochem, 72, pp.1817~1825 (2008)
- Yuminamochi, E., "Interleukin-12-and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill", Immunology, 121, pp.197~206 (2007)
