본문 바로가기
KERD
논문KCI 등재

Immune-stimulating Effect of Lactobacillus plantarum Ln1 Isolated from the Traditional Korean Fermented Food, Kimchi

3

조회

0

다운로드

5

인용

0

참고문헌

키워드

주제분류생물학

초록

ILThis study aimed to determine the immune-stimulating effects of heat-killed Lactobacillus plantarum Ln1 (HK-Ln1) through the production of nitric oxide (NO) and pro-inflammatory cytokine achieved by inducing NF-κB and mitogen-activated protein kinase (MAPK)-signaling pathways in macrophages. HK-Ln1 showed higher NO and cytokine production compared to control (nonstimulated lipopolysaccharide); in addition, the expression of inducible nitric oxide synthase (iNOS) was induced through HK-Ln1treatment. The phosphorylation of IκB-α and p65 increased following treatment by HK-Ln1, which implicates IκB-α degradation and the translocation of p65 to nucleus. In addition, the phosphorylation of MAPKs, ERK 1/2, JNK, and p38 was induced following HK-Ln1 treatment.

Abstract

ILThis study aimed to determine the immune-stimulating effects of heat-killed Lactobacillus plantarum Ln1 (HK-Ln1) through the production of nitric oxide (NO) and pro-inflammatory cytokine achieved by inducing NF-κB and mitogen-activated protein kinase (MAPK)-signaling pathways in macrophages. HK-Ln1 showed higher NO and cytokine production compared to control (nonstimulated lipopolysaccharide); in addition, the expression of inducible nitric oxide synthase (iNOS) was induced through HK-Ln1treatment. The phosphorylation of IκB-α and p65 increased following treatment by HK-Ln1, which implicates IκB-α degradation and the translocation of p65 to nucleus. In addition, the phosphorylation of MAPKs, ERK 1/2, JNK, and p38 was induced following HK-Ln1 treatment.

참고문헌 (24)

  1. Xiaoxing Yang, "Antioxidant properties of a vegetable–fruit beverage fermented with two Lactobacillus plantarum strains", Food Science and Biotechnology, 27(6), pp.1719~1726 (2018), 한국식품과학회[DOI]
  2. Wee Yin Koh, "Evaluation of probiotic potential and anti-hyperglycemic properties of a novel Lactobacillus strain isolated from water kefir grains", Food Science and Biotechnology, 27(5), pp.1369~1376 (2018), 한국식품과학회[DOI]
  3. Eric Banan-Mwine Daliri, "Antihypertensive peptides from whey proteins fermented by lactic acid bacteria", Food Science and Biotechnology, 27(6), pp.1781~1789 (2018), 한국식품과학회[DOI]
  4. Hassan MT, "Heat-killed Bacillus sp. SJ-10 probiotic acts as a growth and humoral innate immunity response enhancer in olive flounder(Paralichthys olivaceus)", Fish Shellfish Immunol, pp.88~ (2019)
  5. Fujii T, "Effects of heat-killed Lactococcus lactis subsp. lactis JCM 5805 on mucosal and systemic immune parameters, and antiviral reactions to influenza virus in healthy adults; a randomized controlled double-blind study", J. Funct. Foods, 35, pp.513~521 (2017)
  6. Adams CA, "The probiotic paradox : Live and dead cells are biological response modifiers", Nutr. Res. Rev, 23, pp.37~46 (2010)
  7. 양서진, "Antioxidant and immune-enhancing effects of probiotic Lactobacillus plantarum 200655 isolated from kimchi", Food Science and Biotechnology, 28(2), pp.491~499 (2019), 한국식품과학회[DOI]
  8. Chang CK, "Effect of lactic acid bacteria isolated from fermented mustard on immune potentiating activity", Asian Pac. J. Prop. Biomed, 5, pp.281~286 (2015)
  9. MacMicking J, "Nitric oxide and macrophage function", Annu. Rev. Immunol, 15, pp.323~350 (1997)
  10. Bogdan C, "Nitric oxide and the immune response", Nat. Immunol, 2, pp.907~916 (2001)
  11. Ahmad W, "Immunomodulatory effects of Tinospora crispa extract and its major compounds on the immune functions of RAW 264.7 macrophages", Int. Immunophamacol., 60, pp.141~151 (2018)
  12. 송명욱, "Probiotic and Antioxidant Properties of Novel Lactobacillus brevis KCCM 12203P Isolated from Kimchi and Evaluation of Immune- Stimulating Activities of Its Heat-Killed Cells in RAW 264.7 Cells", Journal of Microbiology and Biotechnology, 29(12), pp.1894~1903 (2019), 한국미생물·생명공학회[DOI]
  13. Son SH, "Antioxidant and immunostimulatory effect of potential probiotic Lactobacillus paraplantarum SC61 isolated from Korean traditional fermented food, jangajji", Microb. Pathog, 125, pp.486~492 (2018)
  14. Ferreira dos santos T, "Immunomodulatory effects of Lactobacillus plantarum Lp62 on intestinal epithelial and mononuclear cells", Biomed. Res. Int, 2016, pp.8404156~ (2016)
  15. 최학종, "Health Benefits of Lactic Acid Bacteria Isolated from Kimchi, with Respect to Immunomodulatory Effects", Food Science and Biotechnology, 24(3), pp.783~789 (2015), 한국식품과학회[DOI]
  16. Devi SM, "In vitro anti-inflammatory activity among probiotic Lactobacillus species isolated from fermented foods", J. Funct. Foods, 47, pp.19~27 (2018)
  17. 최미주, "Immunomodulatory Effects by Bifidobacterium longum KACC 91563 in Mouse Splenocytes and Macrophages", Journal of Microbiology and Biotechnology, 29(11), pp.1739~1744 (2019), 한국미생물·생명공학회[DOI]
  18. Hur HJ, "Production of nitric oxide, tumor necrosis factor-α and interleukin-6 by RAW cell 264. 7 macrophage cells treated with lactic acid bacteria isolated from kimchi", Biofactors, 21, pp.123~125 (2004)
  19. Li C, "The immunostimulatory effect of novel immunostimulator CH2b with a thiazolidin-4-one ring on the functions of LPS-activated RAW 264.7 macrophages in vitro", Int. Immunopharmacol., 17, pp.698~703 (2013)
  20. Tak PP, "NF-κB : A key role in inflammatory diseases", J. Clin. Invest, 107, pp.7~11 (2001)
  21. Kim KN, "Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages", Eur. J. Pharmacol., 649, pp.369~375 (2010)
  22. Pearson G, "Mitogen-activated protein(MAP)kinase pathways : regulation and physiological functions", Endocr. Rev, 22, pp.153~183 (2001)
  23. Zhang S, "p38 MAPK is involved in the immune response to pathogenic Vibrio in the clam Meretrix petechialis", Fish Shellfish Immunol, 95, pp.456~463 (2019)
  24. Thomas CM, "Probiotics-host communication", Gut Microbes, 3, pp.148~163 (2010)

관련 논문AI추천

Anti-Inflammatory Potential of Probiotic Strain Weissella cibaria JW15 Isolated from Kimchi through Regulation of NF-κB and MAPKs Pathways in LPS-Induced RAW 264.7 Cells배천호, 백현동, 유형석, 이나경, 최애진, 최정숙한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2019 · 제29권 제7호Heat-Killed Lactobacillus plantarum KCTC 13314BP Enhances Phagocytic Activity and Immunomodulatory Effects via Activation of MAPK and STAT3 Pathways양희, 강신달, 김재환, 박정한, 변상균, 송성봉, 이기원, 이덕범, 이지수, 정민주한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2019 · 제29권 제8호Immunostimulatory Effect of Heat-Killed Probiotics on RAW264.7 Macrophages김병용, Kim Byoung Kook, Kim Insu, Kim Kyunghwan, Kwon Yoo Jin, Lim Jong Hyun, Noh Hye-Ji, Park Jung Min, Park Sung Yurb한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2022 · 제32권 제5호Micronized and Heat-Treated Lactobacillus plantarum LM1004 Stimulates Host Immune Responses Via the TLR-2/MAPK/NF-κB Signalling Pathway In Vitro and In Vivo손민, 박용일, 이지선, 이창원, 정일선, 조사랑, 최지원, 최태규한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2019 · 제29권 제5호Differential Cytokine Regulatory Effect of Three Lactobacillus Strains Isolated from Fermented Foods김한근, 이윤두, 전보람, 정대균, 정봉준, 홍이판한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2016 · 제26권 제9호Dead Lactobacillus plantarum Stimulates and Skews Immune Responses toward T helper 1 and 17 Polarizations in RAW 264.7 Cells and Mouse Splenocytes김현웅, 이광원, Hyun-Ah Lee, Kun Young Park한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2016 · 제26권 제3호

이 간행물의 다른 논문 (10건)