A new horizon of precision medicine: combination of the microbiome and extracellular vesicles

참고문헌 (132)

1. "What is precision medicine? MedlinePlus" (2018)[URL]
2. National Research Council, "Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease" (2011), National Academies Press
3. Ginsburg, G. S., "Precision Medicine : From Science to Value", Health Aff, 37, pp.694~701 (2018)
4. Ho, D., "Enabling technologies for personalized and precision medicine", Trends Biotechnol, 38, pp.497~518 (2020)
5. "NIH Human Microbiome Project defines normal bacterial makeup of the body" (2012)[URL]
6. Margulis, L., "Symbiosis as a Source of Evolutionary Innovation:Speciation and Morphogenesis" (1991), Mit Press
7. "Agriculture, Environment and the Developing World: A Future of PCR. Part 4: The Hologenome Plenary lecture at Cold Spring Harbor Laboratory" (1994)[URL]
8. Rosenberg, E., "Microbes drive evolution of animals and plants: the hologenome concept", MBio, 7, pp.e01395–15~ (2016)
9. Bordenstein, S. R., "Host biology in light of the microbiome : ten principles of holobionts and hologenomes", PLoS Biol, 13, pp.e1002226~ (2015)
10. Zaborowski, M. P., "Extracellular vesicles : composition, biological relevance, and methods of study", Bioscience, 65, pp.783~797 (2015)
11. Zhou, X., "The function and clinical application of extracellular vesicles in innate immune regulation", Cell Mol. Immunol, 17, pp.323~334 (2020)
12. Azmi, A. S., "Exosomes in cancer development, metastasis, and drug resistance : a comprehensive review", Cancer Metastasis Rev, 32, pp.623~642 (2013)
13. Cocucci, E., "Ectosome and exosomes : shedding the confusion between extracellular vesicles", Trends Cell Biol, 6, pp.364~372 (2015)
14. Gustafson, D., "Extracellular vesicles as protagonists of diabetic cardiovascular pathology", Front. Cardiovasc. Med, 4, pp.71~ (2017)
15. Akers, J. C., "Biogenesis of extracellular vesicles(EV) : exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies", J. Neurooncol, 113, pp.1~11 (2013)
16. Jinho Yang, "Microbe-derived extracellular vesicles as a smart drug delivery system", Translational and Clinical Pharmacology, 26(3), pp.103~110 (2018), 대한임상약리학회
17. Work, E., "The chemistry and electron microscopy of an extracellular lipopolysaccharide from Escherichia coli", Ann. N. Y. Acad. Sci, 133, pp.438~449 (1966)
18. Dorward, D. W., "Export and intercellular transfer of DNA via membrane blebs of Neisseria gonorrhoeae", J. Bacteriol, 171, pp.2499~2505 (1989)
19. Lee, E. Y., "Gram-positive bacteria produce membrane vesicles: proteomicsbased characterization of Staphylococcus aureus-derived membrane vesicles", Proteomics, 9, pp.5425~5436 (2009)
20. Roier, S., "Bacterial outer membrane vesicle biogenesis: a new mechanism and its implications", Microb. Cell, 3, pp.257~259 (2016)
21. Kulp, A., "Biological functions and biogenesis of secreted bacterial outer membrane vesicles", Annu. Rev. Microbiol, 64, pp.163~184 (2010)
22. McBroom, A. J., "Release of outer membrane vesicles by Gramnegative bacteria is a novel envelope stress response", Mol. Microbiol, 63, pp.545~558 (2007)
23. Roier, S., "A noverl mechanism for the biogenesis of outer membrane vesicles in Gram-negative bacteria", Nat. Commun, 7, pp.10515~ (2016)
24. Rivera, J., "Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins", Proc. Natl Acad. Sci. USA, 107, pp.19002~19007 (2010)
25. Briaud, P., "Extracellular vesicle biogenesis and functions in grampositive bacteria", Infect. Immune, 88, pp.e00433~20 (2020)
26. Brown, L., "Through the wall:extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi", Nat. Rev. Microbiol, 13, pp.620~630 (2015)
27. Allocati, N., "Die for the community : an overview of programmed cell death in bacteria", Cell Death Dis, 6, pp.e1609~ (2015)
28. Lee, E. Y., "Proteomics in gram-negative bacterial outer membrane vesicles", Mass Spectrom. Rev, 27, pp.535~555 (2018)
29. Poste, G., "Lipid vesicles as carriers for introducing materials into cultured cells : influence of vesicle lipid composition on mechanism(s)of vesicle incorporation into cells", Proc. Natl Acad. Sci. USA, 73, pp.1603~1607 (1976)
30. Strahl, H., "Bacterial membranes : structure, domains, and function", Annu. Rev. Microbiol, 71, pp.519~538 (2017)
31. Lopez, D., "Exploring functional membrane microdomains in bacteria : an overview", Curr. Opin. Microbiol, 36, pp.76~84 (2017)
32. Kooijmans, S. A., "Exosome mimetics : a novel class of drug delivery systems", Int. J. Nanomed, 7, pp.1525~1541 (2012)
33. Baldeschwieler, J. D., "Phospholipid vesicle targeting using synthetic glycolipid and other determinants", Ann. N. Y. Acad. Sci, 446, pp.349~367 (1985)
34. Bussian, R. W., "Jr Influence of incorporated cerebrosides on the interaction of liposomes with HeLa cells", Biochim. Biophys. Acta, 471, pp.336~ (1977)
35. Mauk, M. R., "Vesicle targeting : timed release and specificity for leukocytes in mice by subcutaneous injection", Science, 207, pp.309~311 (1980)
36. Mauk, M. R., "Targeting of lipid vesicles : specificity of carbohydrate receptor analogues for leukocytes in mice", Proc. Natl Acad. Sci. USA, 77, pp.4430~4434 (1980)
37. Ashwell, G., "The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins", Adv. Enzymol. Relat. Areas Mol. Biol, 41, pp.99~128 (1974)
38. Achord, D. T., "Inhibition of the rat clearance system for agalacto-orosomucoid by yeast mannans and by mannose", Biochem. Biophys. Res. Commun, 77, pp.409~415 (1977)
39. Stahl, P. D., "Evidence for receptormediated binding of glycoproteins, glycoconjugates, and lysosomal glycosidases by alveolar macrophages", Proc. Natl Acad. Sci. USA, 75, pp.1399~1403 (1978)
40. Choi, D. S., "Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa", Proteomics, 11, pp.3424~3429 (2011)
41. Jeon, J., "Proteomic analysis of extracellular vesicles derived from Propionibacterium acnes", Proteom. Clin. Appl, 11, pp.1600040~ (2017)
42. Tartaglia, N. R., "Staphylococcus aureus extracellular vesicles elicit an immunostimulatory response in vivo on the murine mammary gland", Front Cell Infect. Microbiol, 8, pp.277~ (2018)
43. Hong, S. W., "An important role of alpha-hemolysin in extracellular vesicles on the development of atopic dermatitis induced by Staphylococcus aureus", PLoS ONE, 9, pp.e100499~ (2014)
44. Tsatsaronis, J. A., "Extracellular vesicle RNA: a universal mediator of microbial communication?", Trends Microbiol, 26, pp.401~410 (2018)
45. Sjostrom, A. E., "Membrane vesicle-mediated release of bacterial RNA", Sci. Rep, 5, pp.15329~ (2015)
46. Bitto, N. J., "Bacteria membrane vesicles transport their DNA cargo into host cells", Sci. Rep, 7, pp.7072~ (2017)
47. Eigenbrod, T., "Bacterial RNA: An underestimated stimulus for innate immune responses", J. Immunol, 195, pp.411~418 (2015)
48. Hong, S. W., "Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation", Allergy, 66, pp.351~359 (2011)
49. 김민혜, "A Metagenomic Analysis Provides a Culture-Independent Pathogen Detection for Atopic Dermatitis", Allergy, Asthma & Immunology Research, 9(5), pp.453~461 (2017), 대한천식알레르기학회
50. Choi, E. J., "Propionibacterium acnes-derived extracellular vesicles promote Acnelike phenotypes in human epidermis", J. Invest. Dermatol, 138, pp.1371~1379 (2018)
51. Brandt, E. B., "Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility", J. Allergy Clin. Immunol, 136, pp.295~303 (2015)
52. Yang, J., "Importance of indoor dust biological ultrafine particles in the pathogenesis of chronic inflammatory pulmonary disease", Environ. Health Toxicol, 32, pp.e2017021~ (2017)
53. 양진호, "The impact of bacteria-derived ultrafine dust particles on pulmonary diseases", Experimental and Molecular Medicine, 52, pp.1~10 (2020), 생화학분자생물학회[DOI]
54. Kim, Y. S., "Extracellular vesicles derived from Gram-negative bacteria, such as Escherichia coli, induce emphysema mainly via IL-17A-mediated neutrophilic inflammation", J. Immunol, 194, pp.3361~3368 (2015)
55. Kim, M. R., "Staphylococcus aureus-derived extracellular vesicles induce neutrophilic pulmonary inflammation via both Th1 and Th17 cell responses", Allergy, 67, pp.1271~1281 (2012)
56. Bae, C. H., "Escherichia coli–derived and Staphylococcus aureus–derived extracellular vesicles induce MUC5AC expression via extracellular signal related kinase 1", 2 and p38 mitogen-activated protein kinase in human airway epithelial cells, 2017, pp.7, 91~98
57. Park, K. S., "Pulmonary inflammation induced by bacteria-free outer membrane vesicles from Pseudomonas aeruginosa", Am. J. Respir. Cell Mol. Biol, 49, pp.637~645 (2013)
58. Yang, D., "Dysregulated lung commensal bacteria drive interleukin-17B production to promote pulmonary fibrosis through their outer membrane vesicles", Immunity, 50, pp.692~706 (2019)
59. Kim, Y. S., "Extracellular vesicles, especially derived from Gram-negative bacteria, in indoor dust induce neutrophilic pulmonary inflammation associated with both Th1 and Th17 cell responses", Clin. Exp. Allergy, 43, pp.443~454 (2013)
60. Ellis, T. N., "Virulence and immunomodulatory roles of bacterial outer membrane vesicles", Microbiol. Mol. Biol. Rev, 74, pp.81~94 (2010)
61. 김유선, "IgG Sensitization to Extracellular Vesicles in Indoor Dust Is Closely Associated With the Prevalence of Non-Eosinophilic Asthma, COPD, and Lung Cancer", Allergy, Asthma & Immunology Research, 8(3), pp.198~205 (2016), 대한천식알레르기학회
62. Shin, T. S., "Impact of gut microbiota extracellular vesicles on inflammatory and metabolic disease", J. Clin. Nutr. Food Sci, 2, pp.73~78 (2019)
63. Tlaskalová-Hogenová, H., "The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer : Contribution of germ-free and gnotobiotic animal models of human diseases", Cell Mol. Immunol, 8, pp.110~120 (2011)
64. Michielan, A., "Intestinal permeability in inflammatory bowel disease : pathogenesis, clinical evaluation, and therapy of leaky gut", Mediators Inflamm, 2015, pp.628157~ (2015)
65. Rubino, S. J., "Nod-like receptors in the control of intestinal inflammation", Curr. Opin. Immunol, 24, pp.398~404 (2012)
66. Bielig, H., "NOD-like receptor activation by outer membrane vesicles from Vibrio cholerae non-O1 nonO1390 strains is modulated by the quorum-sensing regulator HapR", Infect. Immune, 79, pp.1418~1427 (2011)
67. Canas, M. A., "Outer membrane vesicles from probiotic and commensal Escherichia coli activate NOD1-mediated immune responses in intestinal epithelial cells", Front. Microbiol, 9, pp.498~ (2018)
68. Gilmore, W. J., "Immunomodulatory roles and novel applications of bacterial membrane vesicles", Mol. Immunnol, 134, pp.72~85 (2021)
69. Mun Sun Choi, "Helicobacter pylori-derived outer membrane vesicles stimulate interleukin 8 secretion through nuclear factor kappa B activation", The Korean Journal of Internal Medicine, 36(4), pp.857~867 (2021), 대한내과학회[DOI]
70. Kasubuchi, M., "Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation", Nutrients, 7, pp.2839~2849 (2015)
71. Choi, Y., "Gut microbe-derived extracellular vesicles induce insulin resistance, thereby impairing glucose metabolism in skeletal muscle", Sci. Rep, 5, pp.15878~ (2015)
72. Seyama, M., "Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver", Biochim. Biophys. Acta, 1866, pp.165731~ (2020)
73. Duan, M. C., "The Treg", Th17 paradigm in lung cancer, 2014, pp.2014, 730380~
74. Reppert, S., "A role for T-bet-mediated tumour immune surveillance in anti-IL-17A treatment of lung cancer", Nat. Commun, 2, pp.600~ (2011)
75. Li, Y., "Effects of IL-17A on the occurrence of lung adenocarcinoma", Cancer Biol. Ther, 12, pp.610~616 (2011)
76. Koyama, K., "Reciprocal CD4+ T-cell balance of effector CD62Llow CD4+and CD62LhighCD25+ CD4+ regulatory T cells in small cell lung cancer reflects disease stage", Clin. Cancer Res, 14, pp.6770~6779 (2008)
77. 최현일, "Helicobacter pylori-derived extracellular vesicles increased in the gastric juices of gastric adenocarcinoma patients and induced inflammation mainly via specific targeting of gastric epithelial cells", Experimental and Molecular Medicine, 49, pp.1~13 (2017), 생화학분자생물학회
78. Cuesta, C. M., "Role of microbiota-derived extracellular vesicles in gut-brain communication", Int. J. Mol. Sci, 22, pp.4235~ (2021)
79. Han, E. C., "Extracellular RNAs in periodontopathogenic outer membrane vesicles promote TNF-α production in human macrophages and cross the blood-brain barrier in mice", FASEB J, 33, pp.13412~13422 (2019)
80. Ha, J. Y., "Delivery of periodontopathogenic extracellular vesicles to brain monocytes and microglial IL-6promotion by RNA cargo", Front. Mol. Biosci, 7, pp.596366~ (2020)
81. Lee, K. E., "The extracellular vesicle of gut microbial Paenalcaligenes hominis is a risk factor for vagus nerve-mediated cognitive impairment", Microbiome, 8, pp.107~ (2020)
82. 양진호, "Brain tumor diagnostic model and dietary effect based on extracellular vesicle microbiome data in serum", Experimental and Molecular Medicine, 52, pp.1~12 (2020), 생화학분자생물학회[DOI]
83. Choi, E. B., "Decreased diversity of nasal microbiota and their secreted extracellular vesicles in patients with chronic rhinosinusitis based on a metagenomic analysis", Allergy, 69, pp.517~526 (2014)
84. Castelino, M., "Optimisation of methods for bacterial skin microbiome investigation: primer selection and comparison of the 454 versus MiSeq platform", BMC Microbiol, 17, pp.23~ (2017)
85. Balvociute, M., "SILVA, RDP, Greengenes, NCBI and OTT - how do these taxonomies compare?", BMC Genomics, 18, pp.114~ (2017)
86. Hendriksen, J. M. T., "Diagnostic and prognostic prediction models", J. Thromb. Haemost, 11, pp.129~141 (2013)
87. Ju Hwan Seo, "The market trend analysis and prospects of cancer molecular diagnostics kits", 생체재료학회지, 22(1), pp.38~45 (2018), 한국생체재료학회[DOI]
88. Lee, J. H., "Metagenome analysis using serum extracellular vesicles identified distinct microbiota in asthmatics", Sci. Rep, 10, pp.15125~ (2020)
89. 양진호, "Diagnostic Models for Atopic Dermatitis Based on Serum Microbial Extracellular Vesicle Metagenomic Analysis: A Pilot Study", Allergy, Asthma & Immunology Research, 12(5), pp.792~805 (2020), 대한천식알레르기학회[DOI]
90. Kim, D. J., "Colorectal cancer diagnostic model utilizing metagenomic and metabolomic data of stool microbial extracellular vesicles", Sci. Rep, 10, pp.2860~ (2020)
91. Cho, E. J., "Circulating microbiota-based metagenomic signature for detection of hepatocellular carcinoma", Sci. Rep, 9, pp.7536~ (2019)
92. Park, J. Y., "Bacteria-derived extracellular vesicles in urine as a novel biomarker for gastric cancer: integration of liquid biopsy and metagenome analysis", Cancers, 13, pp.4687~ (2021)
93. Kim, J. R., "Microbiome markers of pancreatic cancer based on bacteriaderived extracellular vesicles acquired from blood samples: a retrospective propensity score matching analysis", Biology, 10, pp.219~ (2021)
94. Lee, H., "16S rDNA microbiome composition pattern analysis as a diagnostic biomarker for biliary tract cancer", World J. Surg. Oncol, 18, pp.19~ (2020)
95. Kim, S. I., "Metagenomic analysis of serum microbe-derived extracellular vesicles and diagnostic models to differentiate ovarian cancer and benign ovarian tumor", Cancers, 12, pp.1309~ (2020)
96. Jinho Yang, "Lung Disease Diagnostic Model Through IgG Sensitization to Microbial Extracellular Vesicles", Allergy, Asthma & Immunology Research, 12(4), pp.669~683 (2020), 대한천식알레르기학회
97. Shahina Akter, "Potential Health-Promoting Benefits of Paraprobiotics, Inactivated Probiotic Cells", Journal of Microbiology and Biotechnology, 30(4), pp.477~481 (2020), 한국미생물·생명공학회
98. Taverniti, V., "The immunomodulatory properties of probiotic microorganisms beyond their viability(ghost probiotics : proposal of paraprobiotic concept)", Genes Nutr, 6, pp.261~274 (2011)
99. de Almada, C. N., "Paraprobiotics : evidences on their ability to modify biological responses, inactivation methods and perspectives on their application in foods", Trends Food Sci. Technol, 58, pp.96~114 (2016)
100. Pique, N., "Health benefits of heat-killed(tyndallized)probiotics : an overview", Int. J. Mol. Sci, 20, pp.2534~ (2019)
101. Aguilar-Toala, J. E., "Postbiotics: an evolving term within the functional foods field", Trends Food Sci. Technol, 75, pp.105~114 (2018)
102. Fafian-Labora, J. A., "Classical and nonclassical intercellular communication in senescence and ageing", Trends Cell Biol, 30, pp.628~639 (2020)
103. Liu, Y., "Gram-positive bacterial extracellular vesicles and their impact on health and disease", Front. Microbiol, 9, pp.1502~ (2018)
104. Kang, C. S., "Extracellular vesicles derived from gut microbiota, especially Akkermansia muciniphila, protect the progression of dextran sulfate sodiuminduced colitis", PLoS ONE, 8, pp.e76520~ (2013)
105. Ji Hyun Choi, "Lactobacillus paracasei-derived extracellular vesicles attenuate the intestinal inflammatory response by augmenting the endoplasmic reticulum stress pathway", Experimental and Molecular Medicine, 52, pp.1~15 (2020), 생화학분자생물학회[DOI]
106. Chaithanya Chelakkot, "Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions", Experimental and Molecular Medicine, 50, pp.1~11 (2018), 생화학분자생물학회
107. 김민혜, "Lactobacillus plantarum-derived Extracellular Vesicles Protect Atopic Dermatitis Induced by Staphylococcus aureus-derived Extracellular Vesicles", Allergy, Asthma & Immunology Research, 10(5), pp.516~532 (2018), 대한천식알레르기학회
108. Kim, W., "Lactobacillus plantarum-derived extracellular vesicles induce antiinflammatory M2 macrophage polarization in vitro", J. Extracell. Vesicles, 9, pp.1793514~ (2020)
109. Seo, M. K., "Therapeutic effects of kefir grain Lactobacillus-derived extracellular vesicles in mice with 2, 4, 6-trinitrobenzene sulfonic acid-induced inflammatory bowel disease", J. Dairy Sci, 101, pp.8662~8671 (2018)
110. Miyoshi, Y., "Mechanisms underlying enhanced IgA production in Peyer’s patch cells by membrane vesicles derived from Lactobacillus sakei", Biosci. Biotechnol. Biochem, 85, pp.1536~1545 (2021)
111. Kim, J. H., "Extracellular vesicle–derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression", J. Allergy Clin. Immunol, 137, pp.507~516 (2016)
112. Wang, J., "The outer membrane protein Amuc_1100 of Akkermansia muciniphila promotes intestinal 5-HT biosynthesis and extracellular availability through TLR2 signalling", Food Funct, 12, pp.3597~3610 (2021)
113. Poste, G., "Lipid vesicles as carriers for introducing biologically active materials into cells", Methods Cell Biol, 14, pp.33~71 (1976)
114. Sambi, M., "Current challenges in cancer immunotherapy : multimodal approaches to improve efficacy and patient response rates", J. Oncol, 2019, pp.4508794~ (2019)
115. Kim, O. Y., "Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response", Nat. Commun, 8, pp.626~ (2017)
116. Evanovich, E., "Comparative genomic analysis of Lactobacillus plantarum: an overview", Int. J. Genomics, 2019, pp.4973214~ (2019)
117. Juli Choi, "Extracellular Vesicles Derived from Lactobacillus plantarum Increase BDNF Expression in Cultured Hippocampal Neurons and Produce Antidepressant-like Effects in Mice", Experimental Neurobiology, 28(2), pp.158~171 (2019), 한국뇌신경과학회
118. Tian, F., "The therapeutic protection of a living and dead Lactobacillus strain against aluminum-nduced brain and liver injuries in C57BL", 6 mice, 2017, pp.12, e0175398~
119. Davis, D. J., "Lactobacillus plantarum attenuates anxiety-related behavior and protects against stress-induced dysbiosis in adult zebrafish", Sci. Rep, 6, pp.33726~ (2016)
120. Dhaliwal, J., "Lactobacillus plantarum MTCC 9510 supplementation protects from chronic unpredictable and sleep deprivation-induced behaviour, biochemical and selected gut microbial aberrations in mice", J. Appl. Microbiol, 125, pp.257~269 (2018)
121. Bin, L., "Staphylococcus aureus alpha-toxin modulates skin host response to viral infection", J. Allergy Clin. Immunol, 130, pp.683~691 (2012)
122. 이윤진, "Rapid Assessment of Microbiota Changes in Individuals with Autism Spectrum Disorder Using Bacteria-derived Membrane Vesicles in Urine", Experimental Neurobiology, 26(5), pp.307~317 (2017), 한국뇌신경과학회
123. Rhee, S. J., "Comparison of serum microbiome composition in bipolar and major depressive disorders", J. Psychiatr. Res, 123, pp.31~38 (2020)
124. Samra, M., "Urine bacteria-derived extracellular vesicles and allergic airway diseases in children", Int. Arch. Allergy Immunol, 178, pp.150~158 (2019)
125. You, Y. A., "Blood microbial communities during pregnancy are associated with preterm birth", Front. Microbiol, 10, pp.1122~ (2019)
126. Kim, S. S., "Microbiome as a potential diagnostic and predictive biomarker in severe alcoholic hepatitis", Aliment Pharmacol. Ther, 53, pp.540~551 (2021)
127. Shen, Y., "Outer membrane vesicles of a human commensal mediate immune regulation and disease protection", Cell Host Microbe, 12, pp.509~520 (2021)
128. Lopez, P., "Treg-inducing membrane vesicles from Bifidobacterium bifidum LMG13195 as potential adjuvants in immunotherapy", Vaccine, 30, pp.825~829 (2012)
129. Maerz, J. K., "Outer membrane vesicles blebbing contributes to B. vulgatus mpk-mediated immune response silencing", Gut Microbes, 9, pp.1~12 (2018)
130. Kim, O. Y., "Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response", Nat. Commun, 8, pp.626~ (2017)
131. An, J., "Bacterial extracellular vesicles affect endocrine therapy in MCF7 cells", Medicine, 100, pp.e25835~ (2021)
132. AI-Nedawi, K., "Gut commensal microvesicles reproduce parent bacterial signals to host immune and enteric nervous systems", FASEB J, 29, pp.684~695 (2014)

관련 논문AI추천