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가습기살균제 피해사건과 교훈

Health Damages and Lessons of the Use of Humidifier Disinfectants in Korea

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Introduction: After 17 years since the first production of humidifier disinfectants in Korea, Korea Centers for Disease Control and Prevention (KCDC) announced that the odds ratio of lung injury related with humidifier disinfectant usage was 47.3 (95% confidence interval 6.0-369.7) according to a case-control study with 18 adult cases, including 8 pregnant women at a university hospital in Seoul. Results: From September 2011 to April 2012, one-hundred and seventy four victim cases have been reported to an environmental non-governmental group (NGO). We summarized timetable of humidifier disinfectants accidents, analyzed health outcomes (death, lung or lung and heart transplantation, pulmonary disease) of reported victims, and classified some information for humidifier disinfectants with health outcomes, and government action for this accident. Among the victims, number of death cases are 52 (30.0%), including 26babies less than 3 years old. Sixty-nine victims come from twenty-seven family with 2 to 4 members per family. About twenty types of humidifier disinfectant products and about 600,000 product items a year have been sold. Fifty-two death cases used 7 different types of disinfectant products, including imported goods and some private brands of well-known supermarkets. KCDC confirmed inhalation toxicity of 6 products through an animal experimental test, and based on this observation recalled disinfectants containing PHMG (polyhexamethylene guanidine) and PGH (Oligo(2-(2-ethoxy)ethoxyethyl guanidinium chloride). Discussions: The use of these biocides involved highly fatal consequences among biologically vulnerable victims, such as pregnant women, several family member victims after semi-acute exposure. This is the first biocide disaster in Korea with non-specific targets, and unknown scale of victims, warranting concerns on use of biocides in the living environment. Conclusions: Special administrative agency for chemical safety and compensation act for environmental health victims are needed to prevent similar problems.

Abstract

Introduction: After 17 years since the first production of humidifier disinfectants in Korea, Korea Centers for Disease Control and Prevention (KCDC) announced that the odds ratio of lung injury related with humidifier disinfectant usage was 47.3 (95% confidence interval 6.0-369.7) according to a case-control study with 18 adult cases, including 8 pregnant women at a university hospital in Seoul. Results: From September 2011 to April 2012, one-hundred and seventy four victim cases have been reported to an environmental non-governmental group (NGO). We summarized timetable of humidifier disinfectants accidents, analyzed health outcomes (death, lung or lung and heart transplantation, pulmonary disease) of reported victims, and classified some information for humidifier disinfectants with health outcomes, and government action for this accident. Among the victims, number of death cases are 52 (30.0%), including 26babies less than 3 years old. Sixty-nine victims come from twenty-seven family with 2 to 4 members per family. About twenty types of humidifier disinfectant products and about 600,000 product items a year have been sold. Fifty-two death cases used 7 different types of disinfectant products, including imported goods and some private brands of well-known supermarkets. KCDC confirmed inhalation toxicity of 6 products through an animal experimental test, and based on this observation recalled disinfectants containing PHMG (polyhexamethylene guanidine) and PGH (Oligo(2-(2-ethoxy)ethoxyethyl guanidinium chloride). Discussions: The use of these biocides involved highly fatal consequences among biologically vulnerable victims, such as pregnant women, several family member victims after semi-acute exposure. This is the first biocide disaster in Korea with non-specific targets, and unknown scale of victims, warranting concerns on use of biocides in the living environment. Conclusions: Special administrative agency for chemical safety and compensation act for environmental health victims are needed to prevent similar problems.

참고문헌 (17)

  1. "New Disinfectant Product for Humidifier", Maeil Business Newspaper 1994 Dec 16., ~ (1994)
  2. Korea Centers for Disease Control and Prevention, "Interim report of epidemiological investigation on lung injury with unknown cause in Korea", Public Health Weekly Report, 4(45), pp.817~832 (2011)
  3. "Asian Citizen’ Center for Environment and Health.", ~, pp.Report No.122 (2011)
  4. "Asian Citizen’ Center for Environment and Health", ~, pp.Report No.128~129 (2011)
  5. "Asian Citizen’ Center for Environment and Health", ~, pp.Report No.131 (2011)
  6. "Asian Citizen’ Center for Environment and Health.", ~, pp.Report No.132 (2011)
  7. "Asian Citizen’ Center for Environment and Health", ~, pp.Report No.140 (2012)
  8. "Order for withdrawal of six humidifier disinfectants products from the market issued"[URL]
  9. 권정환, "Fatal Misuse of Humidifier Disinfectants in Korea: Importance of Screening Risk Assessment and Implications for Management of Chemicals in Consumer Products", ENVIRONMENTAL SCIENCE TECHNOLOGY, 46(5), pp.2498~2500, AMER CHEMICAL SOC
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  12. "Asian Citizen’ Center for Environment and Health", ~, pp.Report No.139 (2012)
  13. 정해관, "Unrecognized Bomb Hidden in the Babies’ Room: Fatal Pulmonary Damage Related with Use of Biocide in Humidifiers", 환경독성보건학회지, 27, pp.1~3 (2012), 환경독성보건학회
  14. 전병학, "Frequency of Humidifier and Humidifier Disinfectant Usage in Gyeonggi Provine", 환경독성보건학회지, 27, pp.1~4 (2012), 환경독성보건학회
  15. Eun-Hye Kim, "Use of Humidifiers with Children Suffering from Atopic Dermatitis", 환경독성보건학회지, 27, pp.1~2 (2012), 환경독성보건학회
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  17. Choi YY, "Murders of biocide disguised household products. In: special section of humidifier disinfectants- threat of biocide", The Way Living Together, 1, pp.46~49 (2012)

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