한·양약 복용이 간기능이상에 미치는 영향에 대한 연구
Effects of Herbal and Western Medicines on Liver Functions
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Abstract
Objectives:The aim of this study was to evaluate effects of herbal medicine and other associated factors for abnormal liver function tests(especially total bilirubin, AST, ALT, and γGT) levels in outpatients at an oriental medical clinic. Methods:A cross-sectional study based on clinical records was conducted on 1,871 patients at one Oriental medical clinic in Seoul, Korea. 504 patients received a liver function tests for screening and 497 patients ranging from the age of 4 to 74 were chosen for the study. Patients with basal liver disease or DM were excluded during the screening process. Patients were classified into case(abnormal) and control(normal) groups by normal liver function test references. Results and Conclusions:In this study, 33.0% of the patients were females, and 67.0% were males. The mean age was 34.7±11.9 years old. The mean total protein value was 6.78±0.66 g/dL(male 6.79±0.61, female 6.76±0.76), albumin 3.89±0.50g/dL(male 3.94±0.47, female 3.81±0.54), total bilirubin 0.51±0.35㎎/ dL(male 0.54±0.39, female 0.45±0.23), AST 23.31±18.22U/L(male 26.37±20.73, female 17.09±8.72), ALT 33.49± 36.36U/L(male 40.56±41.77, female 19.13±12.64), LDH 258.07±74.84㎎/dL(male 263.68±73.77, female 246.70± 75.92), and γGT 39.64±59.16U/L(male 50.15±69.43, female 17.83±8.36). The percentage of abnormal total bilirubin levels(>1.0) in these patients was 2.6%, abnormal AST levels(>39m, >29f) 8.5%, ALT levels(>47m, >32f) 18.8%, and γGT (>50m, >40f) 19.9%.
참고문헌 (35)
- Eisenberg D, "Trends in alternative medicine use in the United States", 280, pp.1569~1575 (1998), JAMA
- Molassiotis A, "Use of complementary and alternative medicine in cancer patients:a European survey", 16(4), pp.655~663 (2005)
- Simpson N, "Complementary medi- cine use in children:Extent and reasons", 51(472), pp.9146~ (2001)
- Friedman T, "of alternative therapies for children with cancer", 100(6), pp.1~6 (1997), Pediatrics
- "Anonymous program profile:International liaison brings global vision to OAM", 3, pp.3~ (1996), complementary and alternative medicine at the NIH
- Pittler MH, "Systematic review:hepatotoxic events associated with herbal medicinal products", 18, pp.451~471 (2003)
- Zhou S, "Herbal bioactivation:the good, the bad and the ugly", 74(8), pp.935~968 (2004)
- 박해모, "국내에서 보고된 한약 및 민간요법, 건강식품 관련 약인성 간손상에 대한 체계적 고찰", 26(2), pp.152~165 (2005)
- 김동준, "독성 간손상에 관한 다기관 예비연구", 10, pp.80~86 (2004)
- 이지현, "한약재 복용으로 인한 간염 17예에 대한 임상적 고찰", 32(1), pp.69~74 (1998)
- 이동수, "중국산 다이어트 식품에 의한 독성간염 1예", 65, pp.s689~s692 (2003)
- Melart D, "Monitoring of enzymes in patients treated with traditional Chinese drugs", 7, pp.208~216 (1999)
- Al-Khafaji M, "Monitoring of liver enzymes in patients on Chinese medicine", 62, pp.6~10 (2000)
- 이정석, "한·양약복용이 간기능에 미치는 영향", 8(1), pp.59~77 (2004)
- 윤여광, "청심연자탕 투여후 발생한 약물 유인성 간손상 치험 1례", 25(3), pp.539~544 (2004)
- 김미랑, "육미지황원 투여후 발생한 간독성 간염 1예", 23(4), pp.716~721 (2002)
- 김진배, "급성 독성 간손상의 임상적 양상", Clinical and Molecular Hepatology, 10(2004), pp.125~134 (2004), 대한간학회
- 서정철, "단일기관에서 경험한 독성 간염의 임상상", 10(3), pp.S60~ (2001)
- 연종은, "간기능 검사의 원리와 이해", pp.327~336 (2005)
- D. Robert Dufour, "Diagnosis and Monitoring of Hepatic Injury. II. Recommendations for Use of Laboratory Tests in Screening, Diagnosis, and Moni- toring", 46(12), pp.2050~2068 (2000)
- Pratt Ds, "Evaluation of abnormal liver enzyme results in asymp- tomatic patients", 342, pp.1266~1271 (2000)
- Kim HC, "Normal serum aminotransferase concentration and risk of mortality from liver diseases:prospective cohort study", 328, pp.983~986 (2004), BMJ
- 김병익, "건강검진 수진자에서 비알코올성 지방간 및 간기능 장애: 인슐린 저항성과의 관계", 대한소화기학회지, 41(5) (2003), 대한소화기학회
- 김광모, "연속적으로 시행한 공장 근로자 건강검진에서 무증상 간기능검사이상자의 임상적 특성", 11(2), pp.144~156 (2005)
- 채희복, "약인성 간손상의 임상상과 진단", 10, pp.7~18 (2004)
- 백종태, "식물제제에 의한 간 손상의 진단척도의 문제점", pp.s13~ (2003)
- 서정일, "독성 및 약인성 간손상-발생기전", 10, pp.30~44 (2004)
- Sgro C, "Incidence of drug-induced hepatic injuries:a French population-based study", 36(2), pp.451~455 (2002)
- Meier Y, "Incidence of drug-induced liver injury in medical inpatients", 61, pp.135~143 (2005)
- 양재훈, "한약 투여후 발생한 급성담즙정체성(약재유인성) 간염 치험 1례", 22(2), pp.251~256 (2001)
- 한창우, "백선피(Dyctamnus dasycarpus)에 의한 약물유발성 간염1례", 24(2), pp.374~379 (2003)
- Li Jun, "Report 6 Effects of applying integrated therapy with Traditional Chinese medicine and Western medicine on liver and kidney functions in patients with SARS", 302 (2004), Hospital of PLA Beijing
- 이대용, "장기입원환자의 한약투여후 AST, ALT변화", (2), pp.142~148 (2002)
- 윤여광, "청심연자탕으로 인한 간손상 유발가능성에 대한 임상연구", 24(4), pp.792~795 (2003)
- Piton A, "Factors associated with serum alanine transaminase activity in healthy subjects: consequences for the definition of normal values, for selection of blood donors, and for patients with chronic hepatitis C", 27, pp.1213~1219 (1998), MULTIVIRC Group
