마이코플라즈마 폐렴에 의해 용혈성 빈혈이 발현된 유전성 구상 적혈구증 1례
A Case of Hereditary Spherocytosis with Hemolytic Anemia due to Mycoplasma pneumonia
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
5-14세에 호발하는 마이코플라즈마 폐렴은 20-25%에서 폐외 증상을 일으키는 것으로 알려져 있으며 이 중 혈액계 질환에는 용혈성 빈혈, 혈소판 감소증, 혈구포식세포 증식증 (hemophagocytosis) 등이 있다. 마이코플라즈마 폐렴에서의 냉항체에 의한 자가면역성 용혈로 용혈성 빈혈이 발생할 수 있으며, 이 때 항체의 역가와 용혈의 정도에 상관관계가 있을 수 있다. 저자들은 마이코플라즈마 폐렴에 의해 용혈성 빈혈 이 발현된 유전성 구상 적혈구증 1례를 경험하였기에 보고하 는 바이다.
Abstract
Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in children, with a peak incidence at 5-14 years. Extrapulmonary manifestations occur in 20-25% of patients with M. pneumoniae infection. Most auto-antibodies that cause immune hemolytic anemia in humans are cold agglutinins. The formation of cold agglutinins is frequently observed during M. pneumoniae infections, and cold agglutinin disease usually occurs during M. pneumoniae infections. Nevertheless, severe hemolysis is exceptional. If a patient has any underlying disease related to hemolysis, it is possible to accelerate hemolysis. Hereditary spherocytosis is a common cause of hereditary hemolytic anemia resulting from red blood cell membrane defects. Hemolysis of red cells may result from corpuscular abnormalities or extracorpuscular abnormalities, such as immune or non-immune mechanisms. We report a case of hereditary spherocytosis associated with severe hemolytic anemia due to Mycoplasma pneumonia.
참고문헌 (17)
- Waites KB, "Mycoplasma pneumoniae and its role as a human pathogen", Clin Microbiol Rev, 17, pp.697~728 (2004)
- Daxböck F, "Severe hemolytic anemia and excessive leukocytosis masking Mycoplasma pneumonia", Ann Hematol, 80, pp.180~182 (2001)
- Segel GB, "Hereditary Spherocytosis. in: Textbook of pediatrics. 18th ed", pp.2020~2023 (2007), WB Saunders Co
- Eber S, "Hereditary spherocytosis - defects in proteins that connect the membrane skeleton to the lipid bilayer", Semin Hematol, 41, pp.118~141 (2004)
- Tse WT, "Red blood cell membrane disorders", Br J Haematol, 104, pp.2~13 (1999)
- Hassoun H, "Hereditary spherocytosis : a review of the clinical and molecular aspects of the disease", Blood Rev, 10, pp.129~147 (1996)
- Gehrs BC, "Autoimuune hemolytic anemia", Am J Hematol, 69, pp.258~271 (2002)
- Ali NJ, "Harrison BD. The clinical spectrum and diagnosis of Mycoplasma pneumoniae infection", Q J Med, 58, pp.241~251 (1986)
- Inaba H, "A case of hemoglobn SC disease with cold agglutinin-induced hemolysis", Am J Hematol, 78, pp.37~40 (2005)
- Fukuda MN, "Cell surface modification by endo-beta-galactosidase. Change of blood group activities and release of oligosaccharides from glycoproteins and glycosphingolipids of human erythrocytes", J Biol Chem, 254, pp.5458~5465 (1979)
- Loomes LM, "Erythrocyte receptors for Mycoplasma pneumoniae are sialylated oligosaccharides of Ii antigen type", Nature, 307, pp.560~563 (1984)
- Costea N, "The mechanism of induction of cold agglutinins by Mycoplasma pneumoniae", J Immunol, 106, pp.598~604 (1971)
- Feizi T, "Carbohydrate recognition by Mycoplasma pneumoniae and pathologic consequences", Am J Respir Crit Care Med, 4, pp.S133~S136 (1996)
- Palek J, "Clinical expression and laboratory detection of red blood cell membrane protein mutations", Semin Hematol, 30, pp.249~283 (1993)
- Streichman S, "Cryohemolysis for the detection of hereditary spherocytosis : correlation studies with osmotic fragility and autohemolysis", Am J Hematol, 58, pp.206~212 (1998)
- Jaffe CJ, "The role of complement in the clearance of cold agglutinin-sensitized erythrocytes in man", J Clin Invest, 58, pp.942~949 (1976)
- Cherry JD, "Anemia and mucocutaneous lesions due to Mycoplasma pneumoniae infections", Clin Infect Dis, 17(1), pp.S47~S51 (1993)