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한국의 소아 청소년에서 인플루엔자 백신의 효능평가

Protective Field Efficacy Study of Influenza Vaccines for Korean Children and Adolescent in 2010-2011 Season

김동호|강은경|김남희|은병욱|김소희|박기원|장현오|김승연
대한소아감염학회 (The Korean Society of Pediatric Infectious Diseases)|2012.12|Pediatric Infection and Vaccine|제19권 제3호|pp. 149-156

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키워드

Influenza vaccineField efficacy

초록

목 적:소아청소년을 대상으로 2010-2011 인플루엔자 백신의 야외 효능을 확인하고자 하였다. 방 법: 2010년 9월에서 2011년 2월까지 소아 청소년을 대상으로 서울 경기지역의 7개 병원과 1개 초등학교에서 인플루엔자 백신을 접종한 시험군과 접종하지 않은대조군을 모집하였다. 급성 발열성 호흡기 질환 증상이있을시 임상시험기관에 방문하도록 하여 검체를 채취하여 감염여부를 확인하였다. 결 과:시험 군 407명 중 3명(0.74%)에서 3건의 신종H1N1 인플루엔자 바이러스가 검출되었고, 대조군 230명중 10명(4.35%)에서 12건을 검출하여 9명(3.91%)에서9건의 신종 H1N1, 3명(1.30%)에서 3건의 H3N2 인플루엔자 바이러스를 검출하였다. 시험군에서의 인플루엔자발생률은 0.74%, 대조군에서 4.35%였다. 백신의 야외효능은 83.2%였다. 결 론:소아청소년을 대상으로 2010-2011년 인플루엔자 백신의 야외효능은 우수하였음을 확인하였다.

Abstract

Purpose :We conducted a prospective comparative clinical study to determine the field efficacy of the 2010–2011 influenza vaccines [Influenza virus strains; A/California/7/2009 (H1N1), A/Perth/16/2009 (H3N2), B/Brisbane/60/2008] in healthy Korean children under 18 years of age. Methods : In this study, we enrolled subjects aged between 6 months and 18 years and divided them into 2 study groups:a group who received the influenza vaccines (407 subjects), and a control group who did not receive the influenza vaccines (230 subjects). Ours was a multicenter study that involved 7 hospitals, including the Korea Cancer Center Hospital. The study was conducted between September 2010 and February 2011. We collected nasal wash or throat swab samples from subjects who presented with acute febrile respiratory or influenza-like illnesses at the hospital. We used PCR to confirm the presence of the influenza virus in the respiratory samples and characterize the virus type. Results : In this study, we collected 22 respiratory samples from the influenza-vaccinated group and found 3 cases of influenza virus infection. Similarly, we collected 21 samples from the control group and found 12 cases of influenza virus infection among 10 subjects during the study period. We determined the field efficacy of the 2010-2011 seasonal influenza vaccines to be 83.2% in healthy Korean children and adolescents. Conclusion : In this study, we determined the field efficacy of the 2010–2011 seasonal influenza vaccines in healthy Korean children and adolescents. We found that the field efficacy of 2010–2011 seasonal influenza vaccines was adequate.

참고문헌 (22)

  1. "Influenza viruses, In Textbook of pediatric infectious diseases. 6th ed", pp.2395~2413 (2009), WB Saunders Co
  2. Izurieta HS, "Influenza and the rates of hospitalization for respiratory disease among infants and young children", N Engl J Med, 342, pp.232~239 (2000)
  3. Glezen WP, "Acute respiratory disease associated with influenza epidemics in Houston, 1981–1983", J Infect Dis, 155, pp.1119~1126 (1987)
  4. Ki HO, "Korean influenza suveillance report,2010-2011", PHWR, 4, pp.1~20 (2011)
  5. Reichert TA, "The Japanese experience with vaccinating school children against influenza", N Engl J Med, 344, pp.889~896 (2001)
  6. Monto AS, "Modification of an outbreak of influenza in Tecumseh, Michigan, by vaccination of school children", J Infect Dis, 122, pp.16~25 (1970)
  7. Ruben FL, "Inactivated influenza virus vaccines in children", Clin Infect Dis, 38, pp.678~688 (2004)
  8. A review of production technologies for influenza virus vaccines, and their suitability for deployment in developing countries for influenza pandemic preparedness, "Hickling J", World Health Organization Initiative for Vaccine Research, 1~34 (2006)
  9. Fedson DS, "Pandemic influenza and the global vaccine supply", Clin Infect Dis, 36, pp.1552~1561 (2003)
  10. Fedson DS, "Measuring protection: efficacy versus effectiveness", Dev Biol Stand, 95, pp.195~201 (1998)
  11. Osterholm MT, "Efficacy and effectiveness of influenza vaccines: a systemic review and meta-analysis", Lancet Infect Dis, 12, pp.36~44 (2012)
  12. Chang, Hee Kyoung, "Development of Multiplex RT-PCR Assays for Rapid Detection and Subtypingof Influenza Type A Viruses from Clinical Specimens", Journal of Microbiology and Biotechnology, 18(6), pp.1164~1169 (2008), 한국미생물·생명공학회
  13. Dwyer DE, "Laboratory diagnosis of human seasonal and pandemic influenza virus infection", Med J Aust, 185, pp.48~53 (2006)
  14. 송준영, "Immunogenicity and Safety of Trivalent Inactivated Influenza Vaccine: A Randomized, Double-Blind, Multi-Center, Phase 3 Clinical Trial in a Vaccine-Limited Country", Journal of Korean Medical Science, 26(2), pp.191~195 (2011), 대한의학회
  15. Song JY, "Long-term immunogenicity of influenza vaccine among the elderly: Risk factors for poor immune response and persistence", VACCINE, 28(23), pp.3929~3935, ELSEVIER SCI LTD
  16. Langley JM, "Safety and immunogenicity of 2010–2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12–59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: A PHAC", CIHR Influenza Research Network (PCIRN) study, 2012, pp.30, 3389~3394
  17. Smith NM, "Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practice (ACIP)", MMWR Recomm Rep, 55, pp.1~42 (2006)
  18. Hoberman A, "Effectiveness of inactivated influenza vaccine in preventing acute otitis media in young children: a randomized controlled trial", JAMA, 290, pp.1608~1616 (2003)
  19. Neuzil KM, "Efficacy of inactivated and cold-adapted vaccines against influenza A infection, 1985 to 1990: the pediatric experience", Pediatr Infect Dis J, 20, pp.733~740 (2001)
  20. Gruber WC, "Live attenuated and inactivated influenza vaccine in school-age children", Am J Dis Child, 144, pp.595~600 (1990)
  21. Ruben FL, "Prevention and control of influenza. Role of vaccine", Am J Med, 82, pp.31~34 (1987)
  22. Meiklejohn G, "Viral respiratory disease at Lowry Air Force Base in Denver, 1952-1982", J Infect Dis, 148, pp.775~784 (1983)

관련 논문AI추천

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