Effects of Resistance Exercise on mRNA Expression of Brain Neuroplasticity Related Factors in Hippocampus and Cognitive Function in Ovariectomized Rats
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This study aimed to investigate the impact of brain neuroplasticity-related factors’ mRNA expression patterns in the hippocampus and cognitive function in ovariectomized rats following resistance exercise. Twenty-week-old female SD rats (n=30) were randomly divided into normal control (NC, n=10), ovariectomy (OVX, n=10), and ovariectomy + resistance exercise (OVX+REX, n=10) groups. A ladder-climbing exercise, in which rats climbed to the top of ladder with a weight applied to their tails 8 times a day, 3 days a week for 12 weeks, was used for resistance training. After 12 weeks, rats from the OVX group had higher body weights and were significantly lower in the OVX-REX group than in the OVX group. The mRNA expression levels of the brain neuroplasticity-related genes, BDNF, IGF-1 and VEGF were significantly decreased by ovariectomy. However, they were significantly increased in the OVX+REX group compared to that in the OVX group. In addition, the learning and memory function of rats in the OVX group was significantly improved by resistance exercise. These results suggest that resistance exercise contributing to improved learning and memory function may be in part due to increased mRNA expression of brain neuroplasticity-related factors in ovariectomized rats.
Abstract
This study aimed to investigate the impact of brain neuroplasticity-related factors’ mRNA expression patterns in the hippocampus and cognitive function in ovariectomized rats following resistance exercise. Twenty-week-old female SD rats (n=30) were randomly divided into normal control (NC, n=10), ovariectomy (OVX, n=10), and ovariectomy + resistance exercise (OVX+REX, n=10) groups. A ladder-climbing exercise, in which rats climbed to the top of ladder with a weight applied to their tails 8 times a day, 3 days a week for 12 weeks, was used for resistance training. After 12 weeks, rats from the OVX group had higher body weights and were significantly lower in the OVX-REX group than in the OVX group. The mRNA expression levels of the brain neuroplasticity-related genes, BDNF, IGF-1 and VEGF were significantly decreased by ovariectomy. However, they were significantly increased in the OVX+REX group compared to that in the OVX group. In addition, the learning and memory function of rats in the OVX group was significantly improved by resistance exercise. These results suggest that resistance exercise contributing to improved learning and memory function may be in part due to increased mRNA expression of brain neuroplasticity-related factors in ovariectomized rats.
참고문헌 (37)
- 안재형, "Up-regulation of lipolysis genes and increased production of AMP-activated protein kinase protein in the skeletal muscle of rats after resistance training", Journal of exercise rehabilitation, 12(3), pp.163~170 (2016), 한국운동재활학회
- Arsenijevic, Y., "Insulin-like growth factor-I is a differentiation factor for postmitotic CNS stem cell-derived neuronal precursors : distinct actions from those of brain-derived neurotrophic factor", Journal of Neuroscience, 18, pp.2118~2128 (1998)
- Bettio, L., "Modulation of synaptic plasticity by exercise", International Review of Neurobiology, 147, pp.295~322 (2019)[DOI]
- Breen, E. C., "Angiogenic growth factor mRNA responses in muscle to a single bout of exercise", Journal of Applied Physiology, 81, pp.355~361 (1996)[DOI]
- Cassilhas, R. C., "Mood, anxiety, and serum IGF-1 in elderly men given 24 weeks of high resistance exercise", Perceptual and Motor Skills, 110, pp.265~276 (2010)[DOI]
- Chae, C. H., "Forced, moderate-intensity treadmill exercise suppresses apoptosis by increasing the level of NGF and stimulating phosphatidylinositol 3-kinase signaling in the hippocampus of induced aging rats", Neurochemistry International, 55, pp.208~213 (2009)[DOI]
- Cooke, S. F., "Plasticity in the human central nervous system", Brain, 129, pp.1659~1673 (2006)[DOI]
- Cowansage, K. K., "Brain-derived neurotrophic factor : a dynamic gatekeeper of neural plasticity", Current Molecular Pharmacology, 3, pp.12~29 (2010)[DOI]
- Ding, Y. H., "Exercise-induced overexpression of angiogenic factors and reduction of ischemia", reperfusion injury in stroke, 2004, pp.1, 411~420
- Dominguez-Sanchez, M. A., "Acute effects of high intensity, resistance, or combined protocol on the increase of level of neurotrophic factors in physically inactive overweight adults : The brainfit study", Frontiers in Physiology, 9, pp.741~ (2018)[DOI]
- During, M. J., "VEGF, a mediator of the effect of experience on hippocampal neurogenesis", Current Alzheimer Research, 3, pp.29~33 (2006)[DOI]
- Fabel, K., "VEGF is necessary for exercise-induced adult hippocampal neurogenesis", European Journal of Neuroscience, 18, pp.2803~2812 (2003)[DOI]
- Fordyce, D. E., "Physical activity enhances spatial learning performance with an associated alteration in hippocampal protein kinase C activity in C57BL", 6 and DBA, Brain Research, pp.1993, 619[DOI]
- Freitas, D. A., "High intensity interval training modulates hippocampal oxidative stress, BDNF and inflammatory mediators in rats", Physiology & Behavior, 184, pp.6~11 (2018)[DOI]
- Gavin, T. P., "Acute resistance exercise increases skeletal muscle angiogenic growth factor expression", Acta Physiology, 191, pp.139~146 (2007)[DOI]
- Gibbs, R. B., "Estrogen therapy and cognition : a review of the cholinergic hypothesis", Endocrine Reviews, 31, pp.224~253 (2010)[DOI]
- Gillies, G. E., "Estrogen actions in the brain and the basis for differential action in men and women : a case for sex-specific medicines", Pharmacological Reviews, 62, pp.155~198 (2010)[DOI]
- Goveas, J. S., "Depressive symptoms and incidence of mild cognitive impairment and probable dementia in elderly women : The women's health initiative memory study", Journal of the American Geriatrics Society, 59, pp.57~66 (2011)[DOI]
- Hampson, E., "Estrogens, aging, and working memory", Current Psychiatry Report, 20, pp.109~ (2018)[DOI]
- Henderson, V. W., "Cognitive changes after menopause : influence of estrogen", Clinical Obstetrics and Gynecology, 51, pp.618~626 (2008)[DOI]
- Imtiaz, B., "Risk of Alzheimer's disease among users of postmenopausal hormone therapy : A nationwide case-control study", Maturitas, 98, pp.7~13 (2017)[DOI]
- Kim, T. W., "Combined exercise ameliorates ovariectomyinduced cognitive impairment by enhancing cell proliferation and suppressing apoptosis", Menopause, 23, pp.18~26 (2016)[DOI]
- Kimura, M., "The obesity in bilateral ovariectomized rats is related to a decrease in the expression of leptin receptors in the brain", Biochemical and Biophysical Research Communications, 290, pp.1349~1353 (2002)[DOI]
- Krakauer, J. W., "Motor learning : its relevance to stroke recovery and neurorehabilitation", Current Opinion in Neurology, 19, pp.84~90 (2006)[DOI]
- Maass, A., "Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults", Neuroimage, 131, pp.142~154 (2016)[DOI]
- Mannerkorpi, K., "Acute effects of physical exercise on the serum insulin-like growth factor system in women with fibromyalgia", BMC Musculoskeletal Disorders, 18, pp.37~ (2017)[DOI]
- Palmer, T. D., "Vascular niche for adult hippocampal neurogenesis", Journal of Comparative Neurology, 425, pp.479~494 (2000)[DOI]
- Russo-Neustadt, A., "Physical activity-antidepressant treatment combination : impact on brain-derived neurotrophic factor and behavior in an animal model", Behavioural Brain Research, 120, pp.87~95 (2001)[DOI]
- Sales, S., "Effects of 17beta-estradiol replacement on the apoptotic effects caused by ovariectomy in the rat hippocampus", Life Science, 86, pp.832~838 (2010)[DOI]
- Schobersberger, W., "Increase in immune activation, vascular endothelial growth factor and erythropoietin after an ultramarathon run at moderate altitude", Immunobiology, 201, pp.611~620 (2000)[DOI]
- Tang, K., "Exercise-induced VEGF transcriptional activation in brain, lung and skeletal muscle", Respiratory Physiology & Neurobiology, 170, pp.16~22 (2010)[DOI]
- Taylor, L. W., "Effects of resistance exercise intensity on extracellular signal-regulated kinase 1", 2 mitogen-activated protein kinase activation in men, 2012, pp.26, 599~607
- Trejo, J. L., "Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects", Molecular Psychiatry, 12, pp.1118~1128 (2007)[DOI]
- Tsai, S. F., "Long-term moderate exercise rescues age-related decline in hippocampal neuronal complexity and memory", Gerontology, 64, pp.551~561 (2018)[DOI]
- Wade, G. N., "Some effects of ovarian hormones on food intake and body weight in female rats", Journal of Comparative and Physiological Psychology, 88, pp.183~193 (1975)[DOI]
- Yon, J. M., "The ethanol fraction of white rose petal extract abrogates excitotoxicity-induced neuronal damage in vivo and in vitro through inhibition of oxidative stress and proinflammation", Nutrients, 10, pp.1375~ (2018)[DOI]
- Zheng, S., "Exercise training increases spatial memory via reducing contralateral hippocampal NMDAR subunits expression in intracerebral hemorrhage rats", Neuropsychiatric Disease Treatment, 15, pp.1921~1928 (2019)[DOI]
