Treadmill Exercise Improves Memory Function Depending on Circadian Rhythm Changes in Mice
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Purpose: Exercise enhances memory function by increasing neurogenesis in the hippocampus, and circadian rhythms modulate synaptic plasticity in the hippocampus. The circadian rhythm-dependent effects of treadmill exercise on memory function in relation with neurogenesis were investigated using mice. Methods: The step-down avoidance test was used to evaluate short-term memory, the 8-arm maze test was used to test spatial learning ability, and 5-bromo-2’-deoxyuridine immunofluorescence was used to assess neurogenesis. Western blotting was also performed to assess levels of synaptic plasticity-associated proteins, such as brain-derived neurotrophic factor, tyrosine kinase receptor B, phosphorylated cAMP response element-binding protein, early growth response protein 1, postsynaptic density protein 95, and growth-associated protein 43. The mice in the treadmill exercise at zeitgeber 1 group started exercising 1 hour after sunrise, the mice in the treadmill exercise at zeitgeber 6 group started exercising 6 hours after sunrise, and the mice in the treadmill exercise at zeitgeber 13 group started exercising 1 hour after sunset. The mice in the exercise groups were forced to run on a motorized treadmill for 30 minutes once a day for 7 weeks. Results: Treadmill exercise improved short-term memory and spatial learning ability, and increased hippocampal neurogenesis and the expression of synaptic plasticity-associated proteins. These effects of treadmill exercise were stronger in mice that exercised during the day or in the evening than in mice that exercised at dawn. Conclusions: Treadmill exercise improved memory function by increasing neurogenesis and the expression of synaptic plasticity- associated proteins. These results suggest that the memory-enhancing effect of treadmill exercise may depend on circadian rhythm changes.
Abstract
Purpose: Exercise enhances memory function by increasing neurogenesis in the hippocampus, and circadian rhythms modulate synaptic plasticity in the hippocampus. The circadian rhythm-dependent effects of treadmill exercise on memory function in relation with neurogenesis were investigated using mice. Methods: The step-down avoidance test was used to evaluate short-term memory, the 8-arm maze test was used to test spatial learning ability, and 5-bromo-2’-deoxyuridine immunofluorescence was used to assess neurogenesis. Western blotting was also performed to assess levels of synaptic plasticity-associated proteins, such as brain-derived neurotrophic factor, tyrosine kinase receptor B, phosphorylated cAMP response element-binding protein, early growth response protein 1, postsynaptic density protein 95, and growth-associated protein 43. The mice in the treadmill exercise at zeitgeber 1 group started exercising 1 hour after sunrise, the mice in the treadmill exercise at zeitgeber 6 group started exercising 6 hours after sunrise, and the mice in the treadmill exercise at zeitgeber 13 group started exercising 1 hour after sunset. The mice in the exercise groups were forced to run on a motorized treadmill for 30 minutes once a day for 7 weeks. Results: Treadmill exercise improved short-term memory and spatial learning ability, and increased hippocampal neurogenesis and the expression of synaptic plasticity-associated proteins. These effects of treadmill exercise were stronger in mice that exercised during the day or in the evening than in mice that exercised at dawn. Conclusions: Treadmill exercise improved memory function by increasing neurogenesis and the expression of synaptic plasticity- associated proteins. These results suggest that the memory-enhancing effect of treadmill exercise may depend on circadian rhythm changes.
참고문헌 (33)
- Baek SS, "Effects of postnatal treadmill exercise on apoptotic neuronal cell death and cell proliferation of maternal-separated rat pups", Brain Dev, 34, pp.45~56 (2012)
- Kim SE, "Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus", Exp Gerontol, 45, pp.357~365 (2010)
- 김기정, "Effects of treadmill exercise-intensity on short-term memory in the rats born of the lipopolysaccharide-exposed maternal rats", Journal of exercise rehabilitation, 11(6), pp.296~302 (2015), 한국운동재활학회
- Shin MS, "Treadmill exercise ameliorates symptoms of methimazole-induced hypothyroidism through enhancing neurogenesis and suppressing apoptosis in the hippocampus of rat pups", Int J Dev Neurosci, 31, pp.214~223 (2013)
- Farmer J, "Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo", Neuroscience, 124, pp.71~79 (2004)
- O’Callaghan RM, "The effects of forced exercise on hippocampal plasticity in the rat: a comparison of LTP, spatialand non-spatial learning", Behav Brain Res, 176, pp.362~366 (2007)
- Vasuta C, "Effects of exercise on NMDA receptor subunit contributions to bidirectional synaptic plasticity in the mouse dentate gyrus", Hippocampus, 17, pp.1201~1208 (2007)
- 김동희, "Treadmill exercise improves short-term memory by enhancing hippocampal cell proliferation in quinolinic acid-induced Huntington’s disease rats", Journal of exercise rehabilitation, 11(1), pp.5~11 (2015), 한국운동재활학회[DOI]
- Tabuchi A, "Involvement of an upstream stimulatory factor as well as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I", J Biol Chem, 7, pp.35920~35931 (2002)
- Williams JM, "Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation", Brain Res Mol Brain Res, 77, pp.258~266 (2000)
- Radwanska K, "Mechanism for long-term memory formation when synaptic strengthening is impaired", Proc Natl Acad Sci U S A, 108, pp.18471~18475 (2011)
- Routtenberg A, "Adult learning and remodeling of hippocampal mossy fibers: unheralded participant in circuitry for long-lasting spatial memory", Hippocampus, 20, pp.44~45 (2010)
- Chaudhury D, "Circadian regulation of hippocampal long-term potentiation", J Biol Rhythms, 20, pp.225~236 (2005)
- Sgoifo A, "Effects of sleep deprivation on cardiac autonomic and pituitary-adrenocortical stress reactivity in rats", Psychoneuroendocrinology, 31, pp.197~208 (2006)
- Wang G, "Synaptic plasticity in sleep: learning, homeostasis and disease", Trends Neurosci, 34, pp.452~463 (2011)
- 김미아, "Inhibitory Effects of Isoquinoline Alkaloid Berberine on Ischemia-Induced Apoptosis via Activation of Phosphoinositide 3-Kinase", Protein Kinase B Signaling Pathway, 2014, pp.18(3), 115~125[DOI]
- Kempermann G, "Genetic influence on neurogenesis in the dentate gyrus of adult mice", Proc Natl Acad Sci U S A, 94, pp.10409~10414 (1997)
- Persson M, "Situations influencing habits in diet and exercise among nurses working night shift", J Nurs Manag, 14, pp.414~423 (2006)
- Durgan DJ, "The cardiomyocyte circadian clock: emerging roles in health and disease", Circ Res, 106, pp.647~658 (2010)
- Elsner VR, "Effect of different exercise protocols on histone acetyltransferases and histone deacetylases activities in rat hippocampus", Neuroscience, 192, pp.580~587 (2011)
- 김광택, "Do Rotational Shifts Affect Micturition Patterns in Real Practice? A Pilot Study in Healthy, Young Female Nurses", International Neurourology Journal, 18(4), pp.206~212 (2014), 대한배뇨장애요실금학회
- Meerlo P, "New neurons in the adult brain: the role of sleep and consequences of sleep loss", Sleep Med Rev, 13, pp.187~194 (2009)
- 서태범, "Aerobic Exercise Alleviates Ischemia-Induced Memory Impairment by Enhancing Cell Proliferation and Suppressing Neuronal Apoptosis in Hippocampus", International Neurourology Journal, 18(4), pp.187~197 (2014), 대한배뇨장애요실금학회
- van Praag H, "Exercise enhances learning and hippocampal neurogenesis in aged mice", J Neurosci, 25, pp.8680~8685 (2005)
- Ferreira AF, "Shortterm, moderate exercise is capable of inducing structural, BDNFindependent hippocampal plasticity", Brain Res, 1425, pp.111~122 (2011)
- Kochman LJ, "Circadian variation in mouse hippocampal cell proliferation", Neurosci Lett, 406, pp.256~259 (2006)
- Bolton MM, "Long-term regulation of excitatory and inhibitory synaptic transmission in hippocampal cultures by brain-derived neurotrophic factor", Prog Brain Res, 128, pp.203~218 (2000)
- Tabuchi A, "Synaptic plasticity-regulated gene expression: a key event in the long-lasting changes of neuronal function", Biol Pharm Bull, 31, pp.327~335 (2008)
- 이유진, "Adult hippocampal neurogenesis and related neurotrophic factors", BMB reports, 42(5), pp.239~244 (2009), 한국생화학분자생물학회
- Fang ZH, "Effect of treadmill exercise on the BDNF-mediated pathway in the hippocampus of stressed rats", Neurosci Res, 76, pp.187~194 (2013)
- Aguiar AS Jr, "Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: involvement of hippocampal plasticity via AKT, CREB and BDNF signaling", Mech Ageing Dev, 132, pp.560~567 (2011)
- Hu S, "Exercise can increase small heat shock proteins (sHSP) and pre- and post-synaptic proteins in the hippocampus", Brain Res, 1249, pp.191~201 (2009)
- Mizutani K, "Alteration of protein expression profile following voluntary exercise in the perilesional cortex of rats with focal cerebral infarction", Brain Res, 1416, pp.61~68 (2011)