Incidence of Dental Discoloration After Tetracycline Exposure in Korean Children: A Nationwide Population-Based Study
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Purpose: Tetracycline is not recommended for children under 12 by guideline due to the risk of tooth discoloration. We aimed to assess the incidence of dental discoloration in Korean children prescribed tetracyclines and investigate whether its risk was greater in tetracyclineexposed children than in the general population. Methods: This population-based cohort study using the Health Insurance Review and Assessment service database included children aged 0–12 years exposed to tetracyclines for at least 1 day between January 2008 and December 2020. The primary outcome was the incidence rate of dental discoloration ≥6 months after prescription, and the standardized incidence ratio (SIR) was evaluated as secondary outcome. Results: 56,990 children were included—1,735 and 55,255 aged <8 and 8–12 years, respectively. 61% children were prescribed tetracycline for <14 days with mostly secondgeneration tetracyclines, doxycycline (61%) and minocycline (35%). The 5- and 10-year cumulative incidence rates of dental discoloration were 4.1% (95% confidence interval [CI], 3.0–5.7%) and 5.7% (95% CI, 4.1% to 7.8%), respectively, in the 0–7 years age group and 0.8% (95% CI, 0.7% to 0.9%) and 1.3 (95% CI, 1.1% to 1.4%), respectively, in the 8–12 years age group. Tetracycline exposure did not increase such risk compared to that in the general population (SIR, 1.08; 95% CI, 0.69 to 1.60). Conclusions: The incidence of dental discoloration was lower than previously suggested. Relieving the age restriction for prescribing tetracyclines may be considered.
Abstract
Purpose: Tetracycline is not recommended for children under 12 by guideline due to the risk of tooth discoloration. We aimed to assess the incidence of dental discoloration in Korean children prescribed tetracyclines and investigate whether its risk was greater in tetracyclineexposed children than in the general population. Methods: This population-based cohort study using the Health Insurance Review and Assessment service database included children aged 0–12 years exposed to tetracyclines for at least 1 day between January 2008 and December 2020. The primary outcome was the incidence rate of dental discoloration ≥6 months after prescription, and the standardized incidence ratio (SIR) was evaluated as secondary outcome. Results: 56,990 children were included—1,735 and 55,255 aged <8 and 8–12 years, respectively. 61% children were prescribed tetracycline for <14 days with mostly secondgeneration tetracyclines, doxycycline (61%) and minocycline (35%). The 5- and 10-year cumulative incidence rates of dental discoloration were 4.1% (95% confidence interval [CI], 3.0–5.7%) and 5.7% (95% CI, 4.1% to 7.8%), respectively, in the 0–7 years age group and 0.8% (95% CI, 0.7% to 0.9%) and 1.3 (95% CI, 1.1% to 1.4%), respectively, in the 8–12 years age group. Tetracycline exposure did not increase such risk compared to that in the general population (SIR, 1.08; 95% CI, 0.69 to 1.60). Conclusions: The incidence of dental discoloration was lower than previously suggested. Relieving the age restriction for prescribing tetracyclines may be considered.
참고문헌 (24)
- Weisblum B, "Antibiotic inhibitors of the bacterial ribosome", Bacteriol Rev, 32, pp.493~528 (1968)
- Okada T, "Rapid effectiveness of minocycline or doxycycline against macrolide-resistant Mycoplasma pneumoniae infection in a 2011 outbreak among Japanese children", Clin Infect Dis, 55, pp.1642~1649 (2012)
- Tanaka T, "Macrolide-resistant Mycoplasma pneumoniae infection, Japan, 2008-2015", Emerg Infect Dis, 23, pp.1703~1706 (2017)
- D’Alessandro M, "Management of lyme disease in european children : a review for practical purpose", Curr Infect Dis Rep, 19, pp.27~ (2017)
- Diagnosis and management of Q fever — United States, 2013: recommendations from CDC and the Q Fever Working Group, "Anderson A", Center for Disease Control and Prevention, ~ (2013)
- "Research on doxycycline and tooth staining" (2019)[URL]
- Pereyre S, "Mycoplasma pneumoniae : current knowledge on macrolide resistance and treatment", Front Microbiol, 7, pp.974~ (2016)
- 2019 Acute respiratory infection Control Guideline, , Korea Disease Control and Prevention Agency, 127~131 (2019)
- Todd SR, "No visible dental staining in children treated with doxycycline for suspected Rocky Mountain Spotted Fever", J Pediatr, 166, pp.1246~1251 (2015)
- "Announcement on contraindications for combination and contraindications for certain ages" (2007)[URL]
- Wallman IS, "Teeth pigmented by tetracycline", Lancet, 1, pp.827~829 (1962)
- Swallow JN, "Side-effects to antibiotics in cystic fibrosis : dental changes in relation to antibiotic administration", Arch Dis Child, 42, pp.311~318 (1967)
- Shwachman H, "The effect of long-term antibiotic therapy in patients with cystic fibrosis of the pancreas", Antibiot Annu, 6, pp.692~699 (1958)
- Conchie JM, "The incidence of staining of permanent teeth by the tetracyclines", Can Med Assoc J, 103, pp.351~356 (1970)
- Porter PJ, "Controlled study of the effect of prenatal tetracycline on primary dentition", Antimicrob Agents Chemother, 5, pp.668~671 (1965)
- Forti G, "Doxycycline and the teeth", Lancet, 1, pp.782~ (1969)
- Volovitz B, "Absence of tooth staining with doxycycline treatment in young children", Clin Pediatr(Phila), 46, pp.121~126 (2007)
- Kimberlin DW, "Red book: 2021 report of the Committee on Infectious Diseases" (2021), American Academy of Pediatrics
- "Drug utilization review (DUR)" (2023)[URL]
- Gaillard T, "The end of a dogma : the safety of doxycycline use in young children for malaria treatment", Malar J, 16, pp.148~ (2017)
- Reid DJ, "Variation in modern human enamel formation times", J Hum Evol, 50, pp.329~346 (2006)
- Ha SG, "Therapeutic Efficacy and safety of prolonged macrolide, corticosteroid, doxycycline, and levofloxacin against macrolide-unresponsive Mycoplasma pneumoniae pneumonia in children", J Korean Med Sci, 33, pp.e268~ (2018)
- Atar M, "Systemic disorders and their influence on the development of dental hard tissues : a literature review", J Dent, 38, pp.296~306 (2010)
- Son M, "Association between oral health and incidence of pneumonia : a population-based cohort study from Korea", Sci Rep, 10, pp.9576~ (2020)