임상시험 및 대상자보호프로그램(HRPP)의 효과적 운영 방안

Abstract

Since the Korean Ministry of Food and Drug Safety (MFDS) issued the ‘Human Research Protection Program (HRPP) Guideline’ in 2014, they have provided incentives for investigator-initiated trials, education, and internal audits in clinical trial institutions that adhere to HRPP. However, despite the efforts of the government, only 10 of 190 institutions were approved HRPP operation by the MFDS, and the secondary medical institution was only one of them. Therefore, we surveyed the current status of HRPP basic operation and perceptions for secondary medical institutions as clinical trial institutions that have not yet been approved HRPP operation by the MFDS. We used the survey results to find a method for effective HRPP operation depending on institutional characteristics and the scale of clinical trials. The survey results showed that the responding institutions had problems of insufficient and unstable human resources, low awareness due to lack of incentives for HRPP operation, lack of inter-departmental cooperation systems, confusion about Institutional Review Board (IRB) operation support and HRPP basic operation, and lack of guidance about best practices for HRPP operation. To solve these problems, we suggest the following ways. First, it is to design a manpower standard that enables supply and maintenance of professional personnel and business continuity. Second, it is to induce voluntary HRPP operation by reflecting the criteria of HRPP operation in medical institution certification. Third, it is to amend as a guideline for specifying the IRB roles additionally. Finally, it is to provide practical guidelines through selection of model institutions depending on institution characteristics and scale of clinical trials.