Paraneoplastic demyelination in the brain presenting as a clinically occult non-Hodgkin’s lymphoma
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Non-Hodgkin’s lymphoma (NHL) may initially present with atypical neurological manifestations, including paraneoplastic neurological syndromes. Herein, we report the case showing an initial manifestation of systemic NHL with paraneoplastic demyelination in the brain that initially mimicked the symptoms of stroke, seizure, and brain tumor. A high index of suspicion and timely diagnostic workup is required to prevent diagnostic delay and commence proper management of the condition. In this situation, a whole-body FDG PET/CT could be useful to screen for occult malignancy.
Abstract
Non-Hodgkin’s lymphoma (NHL) may initially present with atypical neurological manifestations, including paraneoplastic neurological syndromes. Herein, we report the case showing an initial manifestation of systemic NHL with paraneoplastic demyelination in the brain that initially mimicked the symptoms of stroke, seizure, and brain tumor. A high index of suspicion and timely diagnostic workup is required to prevent diagnostic delay and commence proper management of the condition. In this situation, a whole-body FDG PET/CT could be useful to screen for occult malignancy.
참고문헌 (10)
- Armitage JO, "Non-Hodgkin lymphoma", Lancet, 390, pp.298~310 (2017)
- Rosenfeld MR, "Update on paraneoplastic neurologic disorders", Oncologist, 15, pp.603~617 (2010)
- Giometto B, "Paraneoplastic neurologic syndrome in the PNS Euronetwork database: a European study from 20 centers", Arch Neurol, 67, pp.330~335 (2010)
- Graus F, "Paraneoplastic neurological syndromes in Hodgkin and non-Hodgkin lymphomas", Blood, 123, pp.3230~3238 (2014)
- Graus F, "Recommended diagnostic criteria for paraneoplastic neurological syndromes", J Neurol Neurosurg Psychiatry, 75, pp.1135~1140 (2004)
- Glantz MJ, "The radiographic diagnosis and treatment of paraneoplastic central nervous system disease", Cancer, 73, pp.168~175 (1994)
- Wong K, "Paraneoplastic demyelinating disorder in the brain of a patient with seminoma", J Comput Assist Tomogr, 22, pp.136~138 (1998)
- Gonzales N, "Acute multifocal CNS demyelination as first presentation of systemic malignancy", Neurology, 65, pp.166~ (2005)
- Matsuhisa A, "Utility of F-18 FDG PET", CT in screening for paraneoplastic neurological syndromes, 2012, pp.37, 39~43
- Pavlidis N, "The diagnostic and therapeutic management of leptomeningeal carcinomatosis", Ann Oncol, 15(Suppl 4), pp.iv285~iv291 (2004)