Anti-Ma2 Paraneoplastic Encephalitis in Association with Recurrent Cervical Cancer
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Background Paraneoplastic neurological syndromes are rare, and although they are frequently associated with gynecological malignancies, cervical cancer is a rare cause. The symptoms ofanti-Ma2 encephalitis are diverse and often present prior to the diagnosis of malignancy. Case Report We report a case of a 37-year-old woman with a history of cervical cancer presenting with unexplained weight gain and vertical supranuclear gaze palsy. Magnetic resonanceimaging of the brain revealed lesions within the bilateral hypothalami and midbrain. Anti-Ma2antibodies were eventually found in the serum, prompting a search for malignancy. Recurrentmetastatic cervical cancer was found in the retroperitoneal lymph nodes. Conclusions This is the first report of cervical cancer in association with anti-Ma2 encephalitis, and highlights the need for a high degree of suspicion in patients with a cancer history presenting with neurological symptoms. The symptoms associated with anti-Ma2 encephalitis arediverse and typically precede the diagnosis of cancer in patients, and should trigger a search foran underlying malignancy.
Abstract
Background Paraneoplastic neurological syndromes are rare, and although they are frequently associated with gynecological malignancies, cervical cancer is a rare cause. The symptoms ofanti-Ma2 encephalitis are diverse and often present prior to the diagnosis of malignancy. Case Report We report a case of a 37-year-old woman with a history of cervical cancer presenting with unexplained weight gain and vertical supranuclear gaze palsy. Magnetic resonanceimaging of the brain revealed lesions within the bilateral hypothalami and midbrain. Anti-Ma2antibodies were eventually found in the serum, prompting a search for malignancy. Recurrentmetastatic cervical cancer was found in the retroperitoneal lymph nodes. Conclusions This is the first report of cervical cancer in association with anti-Ma2 encephalitis, and highlights the need for a high degree of suspicion in patients with a cancer history presenting with neurological symptoms. The symptoms associated with anti-Ma2 encephalitis arediverse and typically precede the diagnosis of cancer in patients, and should trigger a search foran underlying malignancy.
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