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HK-1000 약침이 흰쥐의 고지혈증 및 동맥경화증에 미치는 영향

A Study on the Effect of Herbal-acupuncture with HK-1000 Solution on Hyperlipidemia and Arteriosclerosis Induced Rats

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Objective & Methods : The purpose of this study is to observe the effects of HK-1000 Herbal-acupuncture solution at GB34(Yangleungchean) on hyperlipidemia and arteriosclerosis in rats. The author performed several experimental items to analyze the levels of various components and enzymes in serum, urine and liver, as well as the histological change of liver and aorta. Results : 1. HK-1000 herbal-acupuncture infusion increased the cell viability rate, DPPH radical scavenging activity and HMG-CoA reductase inhibition rate in rat liver cells. 2. The levels of total cholesterol, free cholesterol, LDL-cholesterol, phospholipid in serum and AI (atherogenic index) were decreased, and the ratio of HDL to TCL (HDL/TCL) and the level of TG in serum were increased as compared with those of the control group. 3. In the HK-1000 group, serum AST and ALT were significantly lower than those of the HG group and saline group. 4. Hepatic GSH and catalase activities were significantly increased as compared with those of the saline group. Conclusion : From the above results, it is suggested that HK-1000 herbal-acupuncture at GB34 has a therapeutic effect on hyperlipidemia and arteriosclerosis.

Abstract

Objective & Methods : The purpose of this study is to observe the effects of HK-1000 Herbal-acupuncture solution at GB34(Yangleungchean) on hyperlipidemia and arteriosclerosis in rats. The author performed several experimental items to analyze the levels of various components and enzymes in serum, urine and liver, as well as the histological change of liver and aorta. Results : 1. HK-1000 herbal-acupuncture infusion increased the cell viability rate, DPPH radical scavenging activity and HMG-CoA reductase inhibition rate in rat liver cells. 2. The levels of total cholesterol, free cholesterol, LDL-cholesterol, phospholipid in serum and AI (atherogenic index) were decreased, and the ratio of HDL to TCL (HDL/TCL) and the level of TG in serum were increased as compared with those of the control group. 3. In the HK-1000 group, serum AST and ALT were significantly lower than those of the HG group and saline group. 4. Hepatic GSH and catalase activities were significantly increased as compared with those of the saline group. Conclusion : From the above results, it is suggested that HK-1000 herbal-acupuncture at GB34 has a therapeutic effect on hyperlipidemia and arteriosclerosis.

참고문헌 (38)

  1. 박영배, "고지혈증", Medical Postgraduates, 31, pp.160~165 (2003)
  2. 보건복지부, "국민건강영양조사, http:", user.tdf, 2006[DOI]
  3. 전국한의과대학 심계내과학교실, "東醫心系內科學", pp.209~214 (2001), 書苑堂
  4. 전국한의과대학 간계내과학교수, "간계내과학", pp.214~215 (1995), 동양의학연구원출판부
  5. 대한약침학회, "약침제재와 임상응용", pp.1~5 (1997), 대한약침학회
  6. 전국한의과대학 침구경혈학교실, "침구학", pp.648~649 (2000), 집문당
  7. 이기서, "順氣活血湯이 高脂血症에 미치는 影響", 대전대학교 한의학연구소 논문집, 13(2), pp.97~108 (2004)
  8. 이원구, "淸神導痰湯이 食餌性 高脂血症 動物 病態에 미치는 影響", 대전대학교 한의학연구소 논문집, 13(2), pp.109~123 (2004)
  9. 김정현, "除濕順氣湯이 高脂血症 病態 모델에 미치는 影響", 대한한방내과학회지, 27(1), pp.16~26 (2006), 대한한방내과학회
  10. 김한수, "삼백초 열수추출액 섭취가 고지혈증 흰쥐의 생체 내 지질성분 및 대사 효소활성에 미치는 영향", Journal of Exercise Nutrition & Biochemistry, 10(2), pp.99~106 (2006), 한국운동영양학회
  11. 임현정, "고지혈증 환자에서 의학영양치료와 병행하여 섭취한 기능성차(상엽, 구기자, 국화, 대추, 참깨, 나복자)의 혈중 지질 농도 저하 및 항산화 효과", 한국식품영양과학회지, 34(1), pp.42~56 (2005), 한국식품영양과학회
  12. Xie W., "Hypolipidemic mechanisms of Ananas comosus L. leaves in mice: different from fibrates but similar to statins", J pharmacol Sci, 103, pp.267~274 (2007)
  13. Bansal VS, "The phospholipid-N-methyltransferase of rat brain microsomes", Biochim Biophys Acta, 836(1), pp.73~79 (1985)
  14. 徐舜圭, "成人病∙老人病學", pp.38~53 (1992), 高麗醫學
  15. 서울대학교 의과대학출판부, "내분비학", pp.261~ (2005), 서울대학교 의과대학
  16. 유언호, "고지혈증과 동맥경화", 한국지질동맥경화학회, 83(135), pp.p11~ (2003)
  17. 杜鎬京, "東醫腎系學(下)", pp.995~1005 (1991), 東洋醫學硏究院
  18. 신현호, "고지혈증의 약물요법", pp.41~49 (1994), 한국지질학회 제1차 동맥경화와 고지혈증 Workshop
  19. 鄭遇悅, "韓方臨床病理學", pp.545~ (1998), 永林社
  20. 안점우, "족삼리와 양릉천의 침, 전침과 경혈단위 전침기구 자극이 혈중 Gastrin 농도에 미치는 영향", 대한침구의학회지, 21(3), pp.179~192 (2004), 대한침구의학회
  21. 중약대사전 편찬위원회, "완역 중약대사전" (1997), 정담
  22. 전국한의과대학 본초학교실, "본초학" (2000), 영림사
  23. 이경민, "黃耆藥鍼液의 NO, DPPH 消去 및 IL-4 抑制效果", 대한침구의학회지, 20(2), pp.15~ (2003), 대한침구의학회
  24. LEE, M. K., "Naringenin 7-Ocetyl ether as inhibitor of HMG-CoA reductase and modulator of plasma and hepatic lipids in high cholesterol-fed rats", Bioorganic and medicinal chemistry, 11, pp.393~398 (2003)
  25. Bocan, T. M., "HMG-CoA reductase and ACAT inhibitors act synergistically to lower plasma cholesterol and limit atherosclerotic lesion development in the cholesterol-fed rabbit", Atherosclerosis, 139, pp.21~30 (1998)
  26. Martin MJ, "erum cholesterol, blood pressure, and mortality : implications from a cohort of 361662 men", Lancet, 2, pp.933~939 (1986)
  27. 이삼열, "임상병리검사법, 서울", 연세대학교 출판부, pp.273~276 (2001)
  28. 안용호, "高血壓 및 高體重者에서의 혈청 Total cholesterol, HDL-cholesterol, triglyceride와 LDL-cholesterol의 相關性에 관한 硏究", 석사, pp.1987
  29. Berard AM., "High plasma HDL concentrations associated with enhanced atherosclerosis intransgenic mice overexpressing lecithin-cholesteryl acyltransferase", Nat Med, 3, pp.744~749 (1997)
  30. Jurgens G., "Lipoprotein(a) serum concentration and apolipoprotein(a) phenotype correlate with severity and presence of ischemic cerebrovascular disease", Stroke, 26, pp.1841~1848 (1995)
  31. Cristopher, "KG and Joseph, IW : Atherosclerosis : The road ahead", Cell, 104, pp.503~516 (2001)
  32. Anber V., "Role of plasma triglyceride in the regulation of plasma lowdensity lipoprotein(LDL) subfractions : relative contribution of small, dense LDL to coronary heart disease risk", Atherosclerosis, 106, pp.241~253 (1994)
  33. 노환성, "고지혈증 동물 모델 설정을 위한 식이처방의 실험적 연구", 약제학회지, 24(4), pp.297~300 (1994)
  34. 노환성, "고지혈증 랫트를 이용한 수종 전통 한약제의 항고지혈 효과", 임상약학회지, 5(2), pp.61~69 (1995)
  35. 김남재, "한방약물로부터 항고지혈증 치료약물개발(2)-수종 한약재의 항고지혈증 효과-", 생약학회지, 31(2), pp.190~195 (2000)
  36. Ozturk O., "Changes in glucose-6-phosphate dehydrogenase. copper. zinc-superoxide dismutase and catalase activities. glutathione and its metabolizing enzymes. and lipid peroxidation in rat erythrocytes with age", Experimental gerontology, 39(2), pp.211~216 (2004)
  37. 최우석, "玄菟固本丸이 노화유발 백서의 항산화능에 미치는 영향", 大韓韓方內科學會誌, 25(4), pp.147~157 (2004)
  38. Kim, S. M., "The antioxidant and nitrite scavening ability of waste resource (crop shell, sesame meal, korean tangrin peal) extracts", J. Korean Soc. Food Sci. Nutr, 30, pp.589~593 (2001)

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