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Crosstalk between tumor-associated macrophages and neighboring cells in hepatocellular carcinoma

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초록

The tumor microenvironment generally shows a substantial immunosuppressive activity in hepatocellular carcinoma (HCC), accounting for the suboptimal efficacy of immune-based treatments for this difficult-to-treat cancer. The crosstalk between tumor cells and various cell types in the tumor microenvironment is strongly related to HCC progression and treatment resistance. Monocytes are recruited to the HCC tumor microenvironment by various factors and become tumor-associated macrophages (TAMs) with distinct phenotypes. TAMs often contribute to weakened tumor-specific immune responses and a more aggressive phenotype of malignancy. Recent single-cell RNA-sequencing data have demonstrated the central roles of specific TAMs in tumorigenesis and treatment resistance by their interactions with various cell populations in the HCC tumor microenvironment. This review focuses on the roles of TAMs and the crosstalk between TAMs and neighboring cell types in the HCC tumor microenvironment.

Abstract

The tumor microenvironment generally shows a substantial immunosuppressive activity in hepatocellular carcinoma (HCC), accounting for the suboptimal efficacy of immune-based treatments for this difficult-to-treat cancer. The crosstalk between tumor cells and various cell types in the tumor microenvironment is strongly related to HCC progression and treatment resistance. Monocytes are recruited to the HCC tumor microenvironment by various factors and become tumor-associated macrophages (TAMs) with distinct phenotypes. TAMs often contribute to weakened tumor-specific immune responses and a more aggressive phenotype of malignancy. Recent single-cell RNA-sequencing data have demonstrated the central roles of specific TAMs in tumorigenesis and treatment resistance by their interactions with various cell populations in the HCC tumor microenvironment. This review focuses on the roles of TAMs and the crosstalk between TAMs and neighboring cell types in the HCC tumor microenvironment.

참고문헌 (149)

  1. Llovet JM, "Hepatocellular carcinoma", Nat Rev Dis Primers, 7, pp.6~ (2021)
  2. Young Eun Chon, "Hepatocellular carcinoma statistics in South Korea", Clinical and Molecular Hepatology, 27(3), pp.512~514 (2021), 대한간학회[DOI]
  3. Won Sohn, "Obesity and the risk of primary liver cancer: A systematic review and meta-analysis", Clinical and Molecular Hepatology, 27(1), pp.157~174 (2021), 대한간학회[DOI]
  4. Sadahisa Ogasawara, "Switching to systemic therapy after locoregional treatment failure: Definition and best timing", Clinical and Molecular Hepatology, 26(2), pp.155~162 (2020), 대한간학회[DOI]
  5. Galle PR, "Patientreported outcomes with atezolizumab plus bevacizumab versus sorafenib in patients with unresectable hepatocellular carcinoma(IMbrave150) : an open-label, randomised, phase 3trial", Lancet Oncol, 22, pp.991~1001 (2021)
  6. Finn RS, "Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma", N Engl J Med, 382, pp.1894~1905 (2020)
  7. Hilmi M, "Angiogenesis and immune checkpoint inhibitors as therapies for hepatocellular carcinoma : current knowledge and future research directions", J Immunother Cancer, 7, pp.333~ (2019)
  8. Kudo M, "CheckMate 040 cohort 5 : a phase I", II study of nivolumab in patients with advanced hepatocellular carcinoma and Child-Pugh B cirrhosis, 2021, pp.75, 600~609
  9. El-Khoueiry AB, "Nivolumab in patients with advanced hepatocellular carcinoma(CheckMate 040) : an open-label, non-comparative, phase 1", 2 dose escalation and expansion trial, 2017, pp.389, 2492~2502
  10. Sangro B, "Association of inflammatory biomarkers with clinical outcomes in nivolumab-treated patients with advanced hepatocellular carcinoma", J Hepatol, 73, pp.1460~1469 (2020)
  11. Zhou Dexi, "Tumor-Associated Macrophages in Hepatocellular Carcinoma: Friend or Foe?", Gut and Liver, 15(4), pp.500~516 (2021), 거트앤리버 소화기연관학회협의회[DOI]
  12. Park DJ, "Preferential expression of programmed death ligand 1 protein in tumor-associated macrophages and its potential role in immunotherapy for hepatocellular carcinoma", Int J Mol Sci, 22, pp.4710~ (2021)
  13. Thorsson V, "The immune landscape of cancer", Immunity, 48, pp.812~830 (2018)
  14. Cancer Genome Atlas Research Network, "Comprehensive and integrative genomic characterization of hepatocellular carcinoma", Cell, 169, pp.1327~1341 (2017)
  15. Zhang Q, "Landscape and dynamics of single immune cells in hepatocellular carcinoma", Cell, 179, pp.829~845 (2019)
  16. Sun Y, "Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma", Cell, 184, pp.404~421 (2021)
  17. Ho DW, "Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma", Nat Commun, 12, pp.3684~ (2021)
  18. Wang X, "TOX promotes the exhaustion of antitumor CD8+ T cells by preventing PD1 degradation in hepatocellular carcinoma", J Hepatol, 71, pp.731~741 (2019)
  19. Siddiqui I, "Intratumoral Tcf1+PD-1+CD8+ T cells with stem-like properties promote tumor control in response to vaccination and checkpoint blockade immunotherapy", Immunity, 50, pp.195~211 (2019)
  20. Sung PS, "Immunological mechanisms for hepatocellular carcinoma risk after direct-acting antiviral treatment of hepatitis C virus infection", J Clin Med, 10, pp.221~ (2021)
  21. Kim HD, "association between expression level of PD1 by tumor-infiltrating CD8+ T cells and features of hepatocellular carcinoma", Gastroenterology, 155, pp.1936~1950 (2018)
  22. Kurebayashi Y, "Landscape of immune microenvironment in hepatocellular carcinoma and its additional impact on histological and molecular classification", Hepatology, 68, pp.1025~1041 (2018)
  23. Zhang Q, "Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas", Gut, 68, pp.2019~2031 (2019)
  24. Wu C, "Myeloid signature reveals immune contexture and predicts the prognosis of hepatocellular carcinoma", J Clin Invest, 130, pp.4679~4693 (2020)
  25. Nguyen PHD, "Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma", Nat Commun, 12, pp.227~ (2021)
  26. Sung PS, "Realworld outcomes of nivolumab in patients with unresectable hepatocellular carcinoma in an endemic area of hepatitis B virus infection", Front Oncol, 10, pp.1043~ (2020)
  27. Yang H, "Heterogenous responses to nivolumab in a single metastatic nodule in hepatocellular carcinoma : role of salvage surgery", Hepatobiliary Surg Nutr, 8, pp.569~571 (2019)
  28. Cheng AL, "Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma", J Hepatol, 72, pp.307~319 (2020)
  29. Gomez Perdiguero E, "Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors", Nature, 518, pp.547~551 (2015)
  30. Tacke F, "Macrophage heterogeneity in liver injury and fibrosis", J Hepatol, 60, pp.1090~1096 (2014)
  31. Scott CL, "Bone marrow-derived monocytes give rise to selfrenewing and fully differentiated Kupffer cells", Nat Commun, 7, pp.10321~ (2016)
  32. Beattie L, "Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions", J Hepatol, 65, pp.758~768 (2016)
  33. Huang Y, "The role of tumor associated macrophages in hepatocellular carcinoma", J Cancer, 12, pp.1284~1294 (2021)
  34. Su Jong Yu, "Deciphering and Reversing Immunosuppressive Cells in the Treatment of Hepatocellular Carcinoma", Journal of Liver Cancer, 20(1), pp.1~16 (2020), 대한간암학회[DOI]
  35. Ruf B, "Immunobiology and immunotherapy of HCC : spotlight on innate and innate-like immune cells", Cell Mol Immunol, 18, pp.112~127 (2021)
  36. Zhou J, "Tumor-associated macrophages : recent insights and therapies", Front Oncol, 10, pp.188~ (2020)
  37. Heymann F, "Liver inflammation abrogates immunological tolerance induced by Kupffer cells", Hepatology, 62, pp.279~291 (2015)
  38. Mossanen JC, "Chemokine(C-C motif)receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury", Hepatology, 64, pp.1667~1682 (2016)
  39. Malehmir M, "Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer", Nat Med, 25, pp.641~655 (2019)
  40. Diggs LP, "The effects of platelet accumulation in fatty liver disease", Nat Rev Gastroenterol Hepatol, 16, pp.393~394 (2019)
  41. Remmerie A, "Osteopontin expression identifies a subset of recruited macrophages distinct from kupffer cells in the fatty liver", Immunity, 53, pp.641~657 (2020)
  42. Kazankov K, "The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis", Nat Rev Gastroenterol Hepatol, 16, pp.145~159 (2019)
  43. Carpino G, "Increased liver localization of lipopolysaccharides in human and experimental NAFLD", Hepatology, 72, pp.470~485 (2020)
  44. Esparza-Baquer A, "TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms", Gut, 70, pp.1345~1361 (2021)
  45. Ramachandran P, "Resolving the fibrotic niche of human liver cirrhosis at single-cell level", Nature, 575, pp.512~518 (2019)
  46. Mulder K, "Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease", Immunity, 54, pp.1883~1900 (2021)
  47. Sheng J, "Topological analysis of hepatocellular carcinoma tumour microenvironment based on imaging mass cytometry reveals cellular neighbourhood regulated reversely by macrophages with different ontogeny", Gut, 71, pp.1176~1191 (2022)
  48. Yao W, "A natural CCR2antagonist relieves tumor-associated macrophage-mediated immunosuppression to produce a therapeutic effect for liver cancer", EBioMedicine, 22, pp.58~67 (2017)
  49. Li X, "Targeting of tumourinfiltrating macrophages via CCL2", CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma, 2017, pp.66, 157~167
  50. Teng KY, "Blocking the CCL2-CCR2 axis using CCL2-neutralizing antibody is an effective therapy for hepatocellular cancer in a mouse model", Mol Cancer Ther, 16, pp.312~322 (2017)
  51. Avila MA, "Targeting CCL2", CCR2 in tumor-infiltrating macrophages : a tool emerging out of the box against hepatocellular carcinoma, 2019, pp.7, 293~294
  52. Noy R, "Tumor-associated macrophages : from mechanisms to therapy", Immunity, 41, pp.49~61 (2014)
  53. Wu J, "M2 macrophagederived exosomes facilitate HCC metastasis by transferring αM β2 integrin to tumor cells", Hepatology, 73, pp.1365~1380 (2021)
  54. Song G, "Global immune characterization of HBV", HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progression, 2020, pp.6, 90~
  55. Chen DP, "Glycolytic activation of peritumoral monocytes fosters immune privilege via the PFKFB3-PD-L1 axis in human hepatocellular carcinoma", J Hepatol, 71, pp.333~343 (2019)
  56. Chen DP, "Peritumoral monocytes induce cancer cell autophagy to facilitate the progression of human hepatocellular carcinoma", Autophagy, 14, pp.1335~1346 (2018)
  57. 성필수, "Infiltration of T Cells and Programmed Cell Death Ligand 1-expressing Macrophages as a Potential Predictor of Lenvatinib Response in Hepatocellular Carcinoma", Journal of Liver Cancer, 20(2), pp.128~134 (2020), 대한간암학회[DOI]
  58. Lu LC, "Increased expression of programmed death-ligand 1 in infiltrating immune cells in hepatocellular carcinoma tissues after sorafenib treatment", Liver Cancer, 8, pp.110~120 (2019)
  59. Park DJ, "EpCAM-high liver cancer stem cells resist natural killer cellmediated cytotoxicity by upregulating CEACAM1", J Immunother Cancer, 8, pp.e000301~ (2020)
  60. Lee TK, "CD24+liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation", Cell Stem Cell, 9, pp.50~63 (2011)
  61. Barkal AA, "CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy", Nature, 572, pp.392~396 (2019)
  62. Logtenberg MEW, "The CD47-SIRPα immune checkpoint", Immunity, 52, pp.742~752 (2020)
  63. Chen J, "Macrophages induce CD47 upregulation via IL-6 and correlate with poor survival in hepatocellular carcinoma patients", Oncoimmunology, 8, pp.e1652540~ (2019)
  64. Weiskopf K, "CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer", J Clin Invest, 126, pp.2610~2620 (2016)
  65. Xiao Z, "Antibody mediated therapy targeting CD47 inhibits tumor progression of hepatocellular carcinoma", Cancer Lett, 360, pp.302~309 (2015)
  66. Lo J, "Anti-CD47antibody suppresses tumour growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma", Liver Int, 36, pp.737~745 (2016)
  67. Tang KH, "CD133+ liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin", interleukin-8, Hepatology, pp.2012, 55[DOI]
  68. Xiao P, "Neurotensin", IL-8 pathway orchestrates local inflammatory response and tumor invasion by inducing M2 polarization of tumor-associated macrophages and epithelial-mesenchymal transition of hepatocellular carcinoma cells, 2018, pp.7, e1440166~
  69. Lee TK, "Cancer stem cells in hepatocellular carcinoma-from origin to clinical implications", Nat Rev Gastroenterol Hepatol, 19, pp.26~44 (2022)
  70. Yin Z, "IL-6", STAT3 pathway intermediates M1, J Cell Biochem, pp.2018, 119[DOI]
  71. Wan S, "Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells", Gastroenterology, 147, pp.1393~1404 (2014)
  72. Chen Y, "TNF-α derived from M2 tumor-associated macrophages promotes epithelialmesenchymal transition and cancer stemness through the Wnt", β-catenin pathway in SMMC-7721 hepatocellular carcinoma cells, 2019, pp.378, 41~50
  73. Zhang J, "Hypoxiainducible factor-1α", interleukin-1β signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment, 2018, pp.67, 1872~1889
  74. Fu XT, "Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2", STAT3, Int J Oncol, pp.2015, 46[DOI]
  75. Zhong CQ, "FABP4 suppresses proliferation and invasion of hepatocellular carcinoma cells and predicts a poor prognosis for hepatocellular carcinoma", Cancer Med, 7, pp.2629~2640 (2018)
  76. Fan QM, "Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelialmesenchymal transition in hepatocellular carcinoma", Cancer Lett, 352, pp.160~168 (2014)
  77. Xue ST, "The role of the key autophagy kinase ULK1 in hepatocellular carcinoma and its validation as a treatment target", Autophagy, 16, pp.1823~1837 (2020)
  78. Fu XT, "Tumorassociated macrophages modulate resistance to oxaliplatin via inducing autophagy in hepatocellular carcinoma", Cancer Cell Int, 19, pp.71~ (2019)
  79. Guo B, "M2 tumorassociated macrophages produce interleukin-17 to suppress oxaliplatin-induced apoptosis in hepatocellular carcinoma", Oncotarget, 8, pp.44465~44476 (2017)
  80. Sun K, "Autophagydeficient Kupffer cells promote tumorigenesis by enhancing mtROS-NF-κB-IL1α", β-dependent inflammation and fibrosis during the preneoplastic stage of hepatocarcinogenesis, 2017, pp.388, 198~207
  81. Deust A, "Macrophage autophagy protects against hepatocellular carcinogenesis in mice", Sci Rep, 11, pp.18809~ (2021)
  82. Liu LZ, "CCL15recruits suppressive monocytes to facilitate immune escape and disease progression in hepatocellular carcinoma", Hepatology, 69, pp.143~159 (2019)
  83. He Q, "IL-1β-induced elevation of solute carrier family 7 member 11 promotes hepatocellular carcinoma metastasis through up-regulating programmed death ligand 1 and colony-stimulating factor 1", Hepatology, 74, pp.3174~3193 (2021)
  84. Ke M, "MicroRNA-148b-colony-stimulating factor-1 signaling-induced tumor-associated macrophage infiltration promotes hepatocellular carcinoma metastasis", Biomed Pharmacother, 120, pp.109523~ (2019)
  85. Chai ZT, "MicroRNA-26a suppresses recruitment of macrophages by downregulating macrophage colony-stimulating factor expression through the PI3K", Akt pathway in hepatocellular carcinoma, 2015, pp.8, 56~
  86. Ao JY, "Colony-stimulating factor 1 receptor blockade inhibits tumor growth by altering the polarization of tumor-associated macrophages in hepatocellular carcinoma", Mol Cancer Ther, 16, pp.1544~1554 (2017)
  87. Zhu Y, "Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade", Gut, 68, pp.1653~1666 (2019)
  88. Wang Y, "MiR-125a", b inhibits tumor-associated macrophages mediated in cancer stem cells of hepatocellular carcinoma by targeting CD90, 2019, pp.120, 3046~3055
  89. Liu J, "Endoplasmic reticulum stress causes liver cancer cells to release exosomal miR-23a-3p and up-regulate programmed death ligand 1 expression in macrophages", Hepatology, 70, pp.241~258 (2019)
  90. Yin C, "SALL4-mediated upregulation of exosomal miR-146a-5p drives T-cell exhaustion by M2 tumor-associated macrophages in HCC", Oncoimmunology, 8, pp.1601479~ (2019)
  91. Sung PS, "Natural killer cell dysfunction in hepatocellular carcinoma : pathogenesis and clinical implications", Int J Mol Sci, 19, pp.3648~ (2018)
  92. Wu Y, "Monocyte", macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48, Hepatology, pp.2013, 57[DOI]
  93. Ma PF, "Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice", J Hepatol, 67, pp.770~779 (2017)
  94. Kuang DM, "Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1", J Exp Med, 206, pp.1327~1337 (2009)
  95. Wu K, "Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1", programmed death-1 interactions, 2009, pp.69, 8067~8075
  96. Ma J, "PD1Hi CD8+ T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma", J Immunother Cancer, 7, pp.331~ (2019)
  97. Petty AJ, "Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8+ T cell function", JCI Insight, 6, pp.e146707~ (2021)
  98. Chamseddine AN, "Modulating tumorassociated macrophages to enhance the efficacy of immune checkpoint inhibitors : a TAM-pting approach", Pharmacol Ther, 231, pp.107986~ (2022)
  99. Chen CL, "Arginine signaling and cancer metabolism", Cancers(Basel), 13, pp.3541~ (2021)
  100. Pan Y, "Tumor-associated macrophages in tumor immunity", Front Immunol, 11, pp.583084~ (2020)
  101. Geiger R, "L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity", Cell, 167, pp.829~842 (2016)
  102. Kaneda MM, "PI3Kγ is a molecular switch that controls immune suppression", Nature, 539, pp.437~442 (2016)
  103. De Henau O, "Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells", Nature, 539, pp.443~447 (2016)
  104. Sung PS, "Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness", Proc Natl Acad Sci U S A, 112, pp.10443~10448 (2015)
  105. Sung PS, "Interferon response in hepatitis C virusinfected hepatocytes : issues to consider in the era of directacting antivirals", Int J Mol Sci, 21, pp.2583~ (2020)
  106. Lund Laursen T, "Rapid and persistent decline in soluble CD163 with successful direct-acting antiviral therapy and associations with chronic hepatitis C histology", Scand J Gastroenterol, 53, pp.986~993 (2018)
  107. Bolte FJ, "Intra-hepatic depletion of mucosal-associated invariant T cells in hepatitis c virus-induced liver inflammation", Gastroenterology, 153, pp.1392~1403 (2017)
  108. Carlin AF, "Temporal dynamics of inflammatory cytokines", chemokines during sofosbuvir and ribavirin therapy for genotype 2 and 3 hepatitis C infection, 2015, pp.62, 1047~1058
  109. Spaan M, "Immunological analysis during interferon-free therapy for chronic hepatitis C virus infection reveals modulation of the natural killer cell compartment", J Infect Dis, 213, pp.216~223 (2016)
  110. Xiang X, "Targeting tumor-associated macrophages to synergize tumor immunotherapy", Signal Transduct Target Ther, 6, pp.75~ (2021)
  111. Yu S, "Tumor-infiltrating immune cells in hepatocellular carcinoma : Tregs is correlated with poor overall survival", PLoS One, 15, pp.e0231003~ (2020)
  112. Wu Q, "Blocking triggering receptor expressed on myeloid cells-1-positive tumor-associated macrophages induced by hypoxia reverses immunosuppression and anti-programmed cell death ligand 1resistance in liver cancer", Hepatology, 70, pp.198~214 (2019)
  113. Liu C, "Treg cells promote the SREBP1-dependent metabolic fitness of tumor-promoting macrophages via repression of CD8+ T cellderived interferon-γ", Immunity, 51, pp.381~397 (2019)
  114. Ringelhan M, "The immunology of hepatocellular carcinoma", Nat Immunol, 19, pp.222~232 (2018)
  115. Chen MM, "Polarization of tissue-resident TFH-like cells in human hepatoma bridges innate monocyte inflammation and M2b macrophage polarization", Cancer Discov, 6, pp.1182~1195 (2016)
  116. Shalapour S, "Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity", Nature, 551, pp.340~345 (2017)
  117. Sung PS, "Inflammationinduced IgA plus tumor-associated macrophages express PDL1and causes impaired T cell functionality in hepatocellular carcinoma", Hepatology, 72, pp.780A~781A (2022)
  118. Arvanitakis K, "Tumor-associated neutrophils in hepatocellular carcinoma pathogenesis, prognosis, and therapy", Cancers(Basel), 13, pp.2899~ (2021)
  119. Peng ZP, "Glycolytic activation of monocytes regulates the accumulation and function of neutrophils in human hepatocellular carcinoma", J Hepatol, 73, pp.906~917 (2020)
  120. Zhou SL, "Tumor-associated neutrophils recruit macrophages and Tregulatory cells to promote progression of hepatocellular carcinoma and resistance to sorafenib", Gastroenterology, 150, pp.1646~1658 (2016)
  121. Zhou SL, "Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma", Hepatology, 56, pp.2242~2254 (2012)
  122. Singh P, "The immune modulation effect of locoregional therapies and its potential synergy with immunotherapy in hepatocellular carcinoma", J Hepatocell Carcinoma, 7, pp.11~17 (2020)
  123. Chew V, "Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma", Gut, 68, pp.335~346 (2019)
  124. Kang BY, "Phenylboronic acid conjugated to doxorubicin for the treatment of hepatocellular carcinoma through transcatheter arterial chemoembolization", Research Square web stie (2021)[DOI]
  125. Chung YH, "Diffusion-weighted MRI and 18F-FDG PET correlation with immunity in early radiotherapy response in BNL hepatocellular carcinoma mouse model : timeline validation", Eur J Nucl Med Mol Imaging, 46, pp.1733~1744 (2019)
  126. Jeong KY, "Combination of macrophage inflammatory protein 1 alpha with existing therapies to enhance the antitumor effects on murine hepatoma", J Radiat Res, 56, pp.37~45 (2015)
  127. Choi C, "Optimizing radiotherapy with immune checkpoint blockade in hepatocellular carcinoma", World J Gastroenterol, 25, pp.2416~2429 (2019)
  128. Gyu Sang Yoo, "Radiation-induced abscopal effect and its enhancement by programmed cell death 1 blockade in the hepatocellular carcinoma: A murine model study", Clinical and Molecular Hepatology, 27(1), pp.144~156 (2021), 대한간학회[DOI]
  129. Kim HJ, "Clinical significance of soluble programmed cell death ligand-1(sPD-L1)in hepatocellular carcinoma patients treated with radiotherapy", Radiother Oncol, 129, pp.130~135 (2018)
  130. Kudo M, "Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma : a randomised phase 3non-inferiority trial", Lancet, 391, pp.1163~1173 (2018)
  131. Lee J, "Comparative analysis of lenvatinib and hepatic arterial infusion chemotherapy in unresectable hepatocellular carcinoma : a multi-center, propensity score study", J Clin Med, 10, pp.4045~ (2021)
  132. Lee J, "A realworld comparative analysis of lenvatinib and sorafenib as a salvage therapy for transarterial treatments in unresectable HCC", J Clin Med, 9, pp.4121~ (2020)
  133. Kimura T, "Immunomodulatory activity of lenvatinib contributes to antitumor activity in the Hepa1-6 hepatocellular carcinoma model", Cancer Sci, 109, pp.3993~4002 (2018)
  134. Yi C, "Lenvatinib targets FGF receptor 4 to enhance antitumor immune response of anti–programmed cell death-1 in HCC", Hepatology, 74, pp.2544~2560 (2021)
  135. Dong N, "M2 macrophages mediate sorafenib resistance by secreting HGF in a feed-forward manner in hepatocellular carcinoma", Br J Cancer, 121, pp.22~33 (2019)
  136. Chen Y, "CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice", Hepatology, 61, pp.1591~1602 (2015)
  137. Chen Y, "Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha", C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice, 2014, pp.59, 1435~1447
  138. Ou DL, "Regorafenib enhances antitumor immunity via inhibition of p38 kinase", Creb1, J Immunother Cancer, pp.2021, 9[DOI]
  139. Granito A, "Regorafenib combined with other systemic therapies : exploring promising therapeutic combinations in HCC", J Hepatocell Carcinoma, 8, pp.477~492 (2021)
  140. Shang R, "Cabozantinib-based combination therapy for the treatment of hepatocellular carcinoma", Gut, 70, pp.1746~1757 (2021)
  141. Ma L, "Single-cell atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma", J Hepatol, 75, pp.1397~1408 (2021)
  142. Lin C, "Tumour-associated macrophages-derived CXCL8 determines immune evasion through autonomous PD-L1 expression in gastric cancer", Gut, 68, pp.1764~1773 (2019)
  143. Zong Z, "M1 macrophages induce PD-L1 expression in hepatocellular carcinoma cells through IL-1β signaling", Front Immunol, 10, pp.1643~ (2019)
  144. Jansen CS, "An intra-tumoral niche maintains and differentiates stem-like CD8 T cells", Nature, 576, pp.465~470 (2019)
  145. Yan W, "Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages", Gut, 64, pp.1593~1604 (2015)
  146. Li J, "Co-inhibitory molecule B7 superfamily member 1 expressed by tumor-infiltrating myeloid cells induces dysfunction of anti-tumor CD8+ T cells", Immunity, 48, pp.773~786 (2018)
  147. Li G, "Nanoliposome C6-ceramide increases the anti-tumor immune response and slows growth of liver tumors in mice", Gastroenterology, 154, pp.1024~1036 (2018)
  148. Wang B, "Transition of tumor-associated macrophages from MHC class II(hi)to MHC class II(low)mediates tumor progression in mice", BMC Immunol, 12, pp.43~ (2011)
  149. Zhou DY, "Zoledronic acid inhibits infiltration of tumor-associated macrophages and angiogenesis following transcatheter arterial chemoembolization in rat hepatocellular carcinoma models", Oncol Lett, 14, pp.4078~4084 (2017)

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