본문 바로가기
KERD
논문KCI 등재

면역세포와 암세포의 상호작용

Interactions between Immune Cells and Tumor Cells

2

조회

0

다운로드

1

인용

0

참고문헌

키워드

주제분류의학일반

초록

Tumor microenvironment is defined as a heterogeneous complex composed of cancer cells, vascular endothelial cells, fibroblasts, and diverse immune cells. Cancer immunology is the study of interactions between the immune system and cancer cells which is applied to develop therapeutic strategies for human cancers. This review focused on tumor promoting myeloid derived cells such as tumor associated macrophages (TAM) and myeloid derived suppressor cells (MDSC) and their therapeutic applications.

Abstract

Tumor microenvironment is defined as a heterogeneous complex composed of cancer cells, vascular endothelial cells, fibroblasts, and diverse immune cells. Cancer immunology is the study of interactions between the immune system and cancer cells which is applied to develop therapeutic strategies for human cancers. This review focused on tumor promoting myeloid derived cells such as tumor associated macrophages (TAM) and myeloid derived suppressor cells (MDSC) and their therapeutic applications.

참고문헌 (42)

  1. Burnet M, "Cancer; a biological approach. I. The processes of control", Br Med J, 1(5022), pp.779~786 (1957)
  2. Dunn GP, "Cancer immunoediting: from immunosurveillance to tumor escape", Nat Immunol, 3(11), pp.991~998 (2002)
  3. Mantovani A, "Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes", Trends Immunol, 23(11), pp.549~555 (2002)
  4. Mantovani A, "Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation", Hum Immunol, 70(5), pp.325~330 (2009)
  5. Mantovani A, "Macrophages, innate immunity and cancer: balance, tolerance, and diversity", Curr Opin Immunol, 22(2), pp.231~237 (2010)
  6. Steidl C, "Tumor-associated macrophages and survival in classic Hodgkin's lymphoma", N Engl J Med, 362(10), pp.875~885 (2010)
  7. Youn JI, "Subsets of myeloid-derived suppressor cells in tumor-bearing mice", J Immunol, 181(8), pp.5791~5802 (2008)
  8. Hestdal K, "Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells", J Immunol, 147(1), pp.22~28 (1991)
  9. Almand B, "Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer", J Immunol, 166(1), pp.678~689 (2001)
  10. Ochoa AC, "Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma", Clin Cancer Res, 13(2 Pt 2), pp.721s~726s (2007)
  11. Schmielau J, "Activated granulocytes and granulocytederived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients", Cancer Res, 61(12), pp.4756~4760 (2001)
  12. Gabrilovich DI, "Myeloid-derived suppressor cells as regulators of the immune system", Nat Rev Immunol, 9(3), pp.162~174 (2009)
  13. Kusmartsev S, "All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination", Cancer Res, 63(15), pp.4441~4449 (2003)
  14. Mirza N, "All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients", Cancer Res, 66(18), pp.9299~9307 (2006)
  15. Lathers DM, "Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamin D3", Cancer Immunol Immunother, 53(5), pp.422~430 (2004)
  16. Caillou B, "Tumor-associated macrophages (TAMs) form an interconnected cellular supportive network in anaplastic thyroid carcinoma", PLoS One, 6(7), pp.e22567~ (2011)
  17. Ryder M, "Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer", Endocr Relat Cancer, 15(4), pp.1069~1074 (2008)
  18. Wei Q, "Density of Tumor Associated Macrophage Correlates with Lymph Node Metastasis in Papillary Thyroid Carcinoma", Thyroid (2012)
  19. Allavena P, "Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine production", Cancer Res, 65(7), pp.2964~2971 (2005)
  20. Germano G, "Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells", Cancer Res, 70(6), pp.2235~2244 (2010)
  21. Muta M, "Mechanical analysis of tumor growth regression by the cyclooxygenase-2 inhibitor, DFU, in a Walker256 rat tumor model: importance of monocyte chemoattractant protein-1 modulation", Clin Cancer Res, 12(1), pp.264~272 (2006)
  22. Bundred NJ, "Cyclooxygenase-2 inhibition does not improve the reduction in ductal carcinoma in situ proliferation with aromatase inhibitor therapy: results of the ERISAC randomized placebo-controlled trial", Clin Cancer Res, 16(5), pp.1605~1612 (2010)
  23. Antonarakis ES, "Phase II, randomized, placebocontrolled trial of neoadjuvant celecoxib in men with clinically localized prostate cancer: evaluation of drug-specific biomarkers", J Clin Oncol, 27(30), pp.4986~4993 (2009)
  24. Gazzaniga S, "Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft", J Invest Dermatol, 127(8), pp.2031~2041 (2007)
  25. Miselis NR, "Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma", Mol Cancer Ther, 7(4), pp.788~799 (2008)
  26. Meng Y, "Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy", Cancer Res, 70(4), pp.1534~1543 (2010)
  27. Tsagozis P, "Zoledronic acid modulates antitumoral responses of prostate cancer-tumor associated macrophages", Cancer Immunol Immunother, 57(10), pp.1451~1459 (2008)
  28. Watkins SK, "Rapid release of cytoplasmic IL-15 from tumorassociated macrophages is an initial and critical event in IL-12- initiated tumor regression", Eur J Immunol, 39(8), pp.2126~2135 (2009)
  29. Watkins SK, "IL-12 rapidly alters the functional profile of tumor-associated and tumorinfiltrating macrophages in vitro and in vivo", J Immunol, 178(3), pp.1357~1362 (2007)
  30. Hagemann T, ""Re-educating" tumor-associated macrophages by targeting NF-kappaB", J Exp Med, 205(6), pp.1261~1268 (2008)
  31. Rolny C, "HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF", Cancer Cell, 19(1), pp.31~44 (2011)
  32. Kluza E, "Anti-tumor activity of liposomal glucocorticoids: The relevance of liposome-mediated drug delivery, intratumoral localization and systemic activity", J Control Release, 151(1), pp.10~17 (2011)
  33. Canioni D, "High numbers of tumor-associated macrophages have an adverse prognostic value that can be circumvented by rituximab in patients with follicular lymphoma enrolled onto the GELA-GOELAMS FL-2000 trial", J Clin Oncol, 26(3), pp.440~446 (2008)
  34. Pan PY, "Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function", Blood, 111(1), pp.219~228 (2008)
  35. Fricke I, "Vascular endothelial growth factor-trap overcomes defects in dendritic cell differentiation but does not improve antigen-specific immune responses", Clin Cancer Res, 13(16), pp.4840~4848 (2007)
  36. Kusmartsev S, "Oxidative stress regulates expression of VEGFR1 in myeloid cells: link to tumor-induced immune suppression in renal cell carcinoma", J Immunol, 181(1), pp.346~353 (2008)
  37. Sinha P, "Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells", Cancer Res, 67(9), pp.4507~4513 (2007)
  38. Serafini P, "Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function", J Exp Med, 203(12), pp.2691~2702 (2006)
  39. Melani C, "Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma", Cancer Res, 67(23), pp.11438~11446 (2007)
  40. Suzuki E, "Gemcitabine selectively eliminates splenic Gr-1+", CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity, 2005, pp.11(18), 6713~6721
  41. Ko HJ, "A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model", Cancer Res, 67(15), pp.7477~7486 (2007)
  42. De Santo C, "Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination", Proc Natl Acad Sci U S A, 102(11), pp.4185~4190 (2005)

이 간행물의 다른 논문 (10건)