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Roles of heterogenous hepatic macrophages in the progression of liver diseases

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Hepatic macrophages are key immune cells associated with thebroad ranges of liver diseases including steatosis, inflammationand fibrosis. Hepatic macrophages interact with other immunecells and orchestrate hepatic immune circumstances. Recently,the heterogenous populations of hepatic macrophages have beendiscovered termed residential Kupffer cells and monocyte-derivedmacrophages, and identified their distinct population dynamicsduring the progression of various liver diseases. Liver injury leadto Kupffer cells activation with induction of inflammatory cytokinesand chemokines, which triggers recruitment of inflammatorymonocyte-derived macrophages. To understand liver pathology,the functions of different subtypes of liver macrophages shouldbe regarded with different perspectives. In this review, we summarizerecent advances in the roles of hepatic macrophages underliver damages and suggest hepatic macrophages as promisingtherapeutic targets for treating liver diseases.

Abstract

Hepatic macrophages are key immune cells associated with thebroad ranges of liver diseases including steatosis, inflammationand fibrosis. Hepatic macrophages interact with other immunecells and orchestrate hepatic immune circumstances. Recently,the heterogenous populations of hepatic macrophages have beendiscovered termed residential Kupffer cells and monocyte-derivedmacrophages, and identified their distinct population dynamicsduring the progression of various liver diseases. Liver injury leadto Kupffer cells activation with induction of inflammatory cytokinesand chemokines, which triggers recruitment of inflammatorymonocyte-derived macrophages. To understand liver pathology,the functions of different subtypes of liver macrophages shouldbe regarded with different perspectives. In this review, we summarizerecent advances in the roles of hepatic macrophages underliver damages and suggest hepatic macrophages as promisingtherapeutic targets for treating liver diseases.

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