MRI Findings of Triple Negative Breast Cancer: A Comparison with Non-Triple Negative Breast Cancer
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Purpose : To evaluate the magnetic resonance imaging (MRI) and clinicopathological features of triple negative breast cancer, and compare them with those of non-triple negative breast cancer. Materials and Methods : This study included 231 pathologically confirmed breast cancers from January 2007 to May 2008. We retrospectively reviewed the MRI findings according to the Breast Imaging Reporting and Data System (BI-RADS) lexicon: mass or non-mass type, mass shape, mass margin, non-mass distribution, and enhancement pattern. Histologic type, histologic grade, and the results for epidermal growth factor receptor, p53, and Ki 67 were reviewed. Results : Of 231 patients, 43(18.6%) were triple negative breast cancer. Forty triple negative breast cancers (93.0%) were mass-type lesion on MRI. A round or oval or lobular shape (p=0.006) and rim enhancement (p=0.004) were significantly more in triple negative breast cancer than non- triple negative breast cancer. In contrast, irregular shape (p=0.006) and spiculated margins (p=0.032) were significantly more in non-triple negative breast cancer. Old age (p=0.019), high histologic grade (p<0.0001), EGFR positivity (p<0.0001), p53 overexpression (p=0.038), and Ki 67 expression (<0.0001) were significantly associated with the triple negative breast cancer. Conclusion : MRI finding may be helpful for differentiation between triple negative and non-triple negative breast cancer.
Abstract
Purpose : To evaluate the magnetic resonance imaging (MRI) and clinicopathological features of triple negative breast cancer, and compare them with those of non-triple negative breast cancer. Materials and Methods : This study included 231 pathologically confirmed breast cancers from January 2007 to May 2008. We retrospectively reviewed the MRI findings according to the Breast Imaging Reporting and Data System (BI-RADS) lexicon: mass or non-mass type, mass shape, mass margin, non-mass distribution, and enhancement pattern. Histologic type, histologic grade, and the results for epidermal growth factor receptor, p53, and Ki 67 were reviewed. Results : Of 231 patients, 43(18.6%) were triple negative breast cancer. Forty triple negative breast cancers (93.0%) were mass-type lesion on MRI. A round or oval or lobular shape (p=0.006) and rim enhancement (p=0.004) were significantly more in triple negative breast cancer than non- triple negative breast cancer. In contrast, irregular shape (p=0.006) and spiculated margins (p=0.032) were significantly more in non-triple negative breast cancer. Old age (p=0.019), high histologic grade (p<0.0001), EGFR positivity (p<0.0001), p53 overexpression (p=0.038), and Ki 67 expression (<0.0001) were significantly associated with the triple negative breast cancer. Conclusion : MRI finding may be helpful for differentiation between triple negative and non-triple negative breast cancer.
참고문헌 (24)
- Reis-Filho JS, "Triple negative tumours: a critical review", Histopathology, 52, pp.108~118 (2008)
- Iwase H, "Clinicopathological analyses of triple negative breast cancer using surveillance data from the Registration Committee of the Japanese Breast Cancer Society", Breast Cancer, 17, pp.118~124
- Dent R, "Triple-negative breast cancer: clinical features and patterns of recurrence", Clin Cancer Res, 13, pp.4429~4434 (2007)
- Trivers KF, "The epidemiology of triple-negative breast cancer, including race", Cancer Causes Control, 20, pp.1071~1082 (2009)
- Uematsu T, "Triple-negative breast cancer: correlation between MR imaging and pathologic findings", Radiology, 250, pp.638~647 (2009)
- Chen JH, "Triple-negative breast cancer: MRI features in 29 patients", Ann Oncol, 18, pp.2042~2043 (2007)
- Yang WT, "Mammographic features of triple receptor-negative primary breast cancers in young premenopausal women", Breast Cancer Res Treat, 111, pp.405~410 (2008)
- Facius M, "Characteristics of ductal carcinoma in situ in magnetic resonance imaging", Clin Imaging, 31, pp.394~400 (2007)
- Rosen EL, "Peacock SLehman CD. BI-RADS MRI enhancement characteristics of ductal carcinoma in situ", Breast J, 13, pp.545~550 (2007)
- Weigelt B, "Metaplastic breast carcinomas are basal-like breast cancers: a genomic profiling analysis", Breast Cancer Res Treat, 117, pp.273~280 (2009)
- Reis-Filho JS, "Metaplastic breast carcinomas are basal-like tumours", Histopathology, 49, pp.10~21 (2006)
- Leibl S, "Metaplastic breast carcinomas are negative for Her-2 but frequently express EGFR (Her-1): potential relevance to adjuvant treatment with EGFR tyrosine kinase inhibitors?", J Clin Pathol, 58, pp.700~704 (2005)
- Reis-Filho JS, "Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis", Breast Cancer Res, 7, pp.R1028~1035 (2005)
- Kuroda N, "Basal-like carcinoma of the breast: further evidence of the possibility that most metaplastic carcinomas may be actually basal-like carcinomas", Med Mol Morphol, 41, pp.117~120 (2008)
- Sasaki Y, "Clinicopathological characteristics of triple-negative breast cancers", Breast Cancer, 16, pp.254~259 (2009)
- Corkery B, "Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer", Ann Oncol, 20, pp.862~867 (2009)
- Rolland P, "The p53 positive Bcl-2 negative phenotype is an independent marker of prognosis in breast cancer", Int J Cancer, 120, pp.1311~1317 (2007)
- Viale G, "Invasive ductal carcinoma of the breast with the triple-negative phenotype: prognostic implications of EGFR immunoreactivity", Breast Cancer Res Treat, 116, pp.317~328 (2009)
- Biswas DK, "Linkage between EGFR family receptors and nuclear factor kappaB (NF-kappaB) signaling in breast cancer", J Cell Physiol, 209, pp.645~652 (2006)
- Nogi H, "EGFR as paradoxical predictor of chemosensitivity and outcome among triplenegative breast cancer", Oncol Rep, 21, pp.413~417 (2009)
- Chae BJ, "p53 as a specific prognostic factor in triple-negative breast cancer", Jpn J Clin Oncol, 39, pp.217~224 (2009)
- Yamamoto Y, "Clinical significance of basal-like subtype in triplenegative breast cancer", Breast Cancer, 16, pp.260~267 (2009)
- Viale G, "Predictive value of tumor Ki-67 expression in two randomized trials of adjuvant chemoendocrine therapy for node-negative breast cancer", J Natl Cancer Inst, 100, pp.207~212 (2008)
- Ding SL, "Expression of estrogen receptor-alpha and Ki67 in relation to pathological and molecular features in early-onset infiltrating ductal carcinoma", J Biomed Sci, 11, pp.911~919 (2004)
