Imaging Features of Mucinous Breast Carcinoma
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Purpose : To examine the imaging findings of mucinous breast carcinoma and to evaluate the difference in these findings based on the histopathologic grade. Materials and Methods : We retrospectively analyzed the imaging features according to BI-RADS in 29 patients with surgically proven mucinous carcinoma. The histopathologic grade was classified as well-differentiated, moderately-differentiated and poorly-differentiated. Based on these criteria, the differences in imaging findings were statistically analyzed. Results : Mammography was available in 20 cases, which contained 17 mass lesions (85%) and 3 cases of normal findings. On ultrasonography (27 cases), mucinous carcinoma was observed as a mass with an oval shape (59.3%), a microlobulated margin (55.6%) or an inhomogeneous isoechogenicity (74.1%). On MRI (21 cases), mucinous carcinoma was commonly observed to have a lobular shape (76%), smooth margin (86%) or heterogeneous contrast-enhancement (61.9%). On the kinetic curve, there was a delayed wash-out pattern (52.3%). There were no significant differences in the imaging findings for each histopathologic grade except that a welldifferentiated tumor had an abrupt interface. Conclusion : A well-differentiated mucinous carcinoma tended to have an abrupt interface on ultrasonography, as compared with the moderately-differentiated one. Mucinous carcinoma showed a heterogeneous enhancement and a delayed washout kinetic curve pattern on dynamic MRI.
Abstract
Purpose : To examine the imaging findings of mucinous breast carcinoma and to evaluate the difference in these findings based on the histopathologic grade. Materials and Methods : We retrospectively analyzed the imaging features according to BI-RADS in 29 patients with surgically proven mucinous carcinoma. The histopathologic grade was classified as well-differentiated, moderately-differentiated and poorly-differentiated. Based on these criteria, the differences in imaging findings were statistically analyzed. Results : Mammography was available in 20 cases, which contained 17 mass lesions (85%) and 3 cases of normal findings. On ultrasonography (27 cases), mucinous carcinoma was observed as a mass with an oval shape (59.3%), a microlobulated margin (55.6%) or an inhomogeneous isoechogenicity (74.1%). On MRI (21 cases), mucinous carcinoma was commonly observed to have a lobular shape (76%), smooth margin (86%) or heterogeneous contrast-enhancement (61.9%). On the kinetic curve, there was a delayed wash-out pattern (52.3%). There were no significant differences in the imaging findings for each histopathologic grade except that a welldifferentiated tumor had an abrupt interface. Conclusion : A well-differentiated mucinous carcinoma tended to have an abrupt interface on ultrasonography, as compared with the moderately-differentiated one. Mucinous carcinoma showed a heterogeneous enhancement and a delayed washout kinetic curve pattern on dynamic MRI.
참고문헌 (22)
- Conant EF, Dillon RL, "Imaging findings in mucin-containing carcinomas of the breast: correlation with pathologic features", AJR Am J Roentgenol, 163, pp.821~824 (1994)
- Dhillon R, "Screen-detected mucinous carcinoma: potential for delayed diagnosis", Clin Radiol, 61, pp.423~430 (2006)
- Cardenosa G, "Mucinous (colloid) breast cancer: clinical and mammographic findings in 10 patients", AJR Am J Roentgenol, 162, pp.1077~1079 (1994)
- Wilson TE, "Pure and mixed mucinous carcinoma of the breast: pathologic basis for differences in mammographic appearance", AJR Am J Roentgenol, 165, pp.285~289 (1995)
- Matsuda M, "Mammographic and clinicopathological features of mucinous carcinoma of the breast", Breast Cancer, 7, pp.65~70 (2000)
- Kushwara AC, "Mucinous carcinoma of the breast", AJR Am J Roentgenol, 173, pp.173~290 (1999)
- Goodman DN, "Mammographic features of puremucinous carcinoma of the breast with pathological correlation", Can Assoc Radiol J, 46, pp.296~301 (1995)
- Svane G, "Screening mammography", pp.296~311 (1993), MO: Mosby
- Kopans DB, "Breast imaging", pp.298~ (1989), Lippincott
- Parsons CA, "Diagnosis of breast disease: imaging, clinical features and pathology", pp.142~162 (1983), University Park Press
- Pina Insausti LJ, "Mucinous breast carcinoma showing as a cluster of suspicious microcalcifications on mammography", Eur Radiol, 8, pp.1666~1668 (1998)
- Memis A, "Mucinous breast cancer: mammographic and US features with histologic correlation", Eur J Radiol, 35, pp.39~43 (2000)
- Lam WW, "Sonographic appearance of mucinous carcinoma of the breast", AJR Am J Roentgenol, 182, pp.1069~1074 (2004)
- Chopra S, "Pure mucinous breast cancer: mammographic and ultrasound findings", Clin Radiol, 51, pp.421~424 (1996)
- Stavros AT, "Malignant solid breast nodules: specific types. In:Stavros AT, editor. Breast ultrasound", pp.645~648 (2003), Lipincott Williams & Wilkins
- Kamitani Kumiko, "Isoechoic axillary lymph node metastases of mucinous carcinoma of the breast: a case report", Breast cancer, 13, pp.382~385 (2006)
- Kawashima M, "MR imaging of mucinous carcinoma of the breast", AJR Am J Roentgenol, 179, pp.179~183 (2002)
- Takashi Okafuji, "MR imaging features of pure mucinous carcinoma of the breast", Eur J Radiol, 60, pp.405~413 (2006)
- Yuen S, "Breast carcinomas with strong high-signal intensity on T2-weighted MR images:pathological characteristics and differential diagnosis", J Magn Reson Imaging, 25, pp.502~510 (2007)
- Shuichi Monzawa, "Mucinous Carcinoma of the Breast: MRI Features of Pure and Mixed Forms with Histopathologic Correlation", AJR Am J Roentgenol, 192, pp.125~131 (2009)
- Clayton F, "Pure mucinous carcinoma of the breast: morphologic features and prognostic correlates", Hum Pathol, 17, pp.34~38 (1986)
- Wedegartner U, "Differentiation between benign and malignant findings on MR-mammography: usefulness of morphological criteria", Eur Radiol, 11, pp.1645~1650 (2001)