Magnetic Resonance Imaging of Breast Cancer Patients with BRCA Mutation
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose : To evaluate the MRI findings of breast cancer with BRCA mutation. Materials and Methods: We collected information of the breast cancer patients who underwent the test for BRCA gene mutation as well as preoperative breast MRI from January 2007 to December 2010. A total of 185 patients were enrolled;33 of these patients had BRCA mutations and 152 patients did not. Among them, a total of 231 breast cancers were detected. Images of the 47 breast cancers with BRCA mutation and of the 184 breast cancers without mutations were evaluated to compare the morphologic and enhancement features on MRI. Results: With MR imaging, there were no significant difference in morphologic characteristic between two groups. However, enhancement pattern in the group with BRCA mutation were more likely to have persistent enhancement (p <0.233), and LN metastasis was more common in breast cancers without BRCA mutation. Breast cancers with BRCA 2mutation tend to show more persistent enhancement pattern than BRCA 1 mutation. Conclusion: In breast cancer patients with BRCA mutation, MRI didn’t show significant difference in morphologic characteristics,however breast cancers with BRCA gene mutation carriers tend to have benign morphologic features on MRI,such as Type 1 kinetic curve enhancement.
Abstract
Purpose : To evaluate the MRI findings of breast cancer with BRCA mutation. Materials and Methods: We collected information of the breast cancer patients who underwent the test for BRCA gene mutation as well as preoperative breast MRI from January 2007 to December 2010. A total of 185 patients were enrolled;33 of these patients had BRCA mutations and 152 patients did not. Among them, a total of 231 breast cancers were detected. Images of the 47 breast cancers with BRCA mutation and of the 184 breast cancers without mutations were evaluated to compare the morphologic and enhancement features on MRI. Results: With MR imaging, there were no significant difference in morphologic characteristic between two groups. However, enhancement pattern in the group with BRCA mutation were more likely to have persistent enhancement (p <0.233), and LN metastasis was more common in breast cancers without BRCA mutation. Breast cancers with BRCA 2mutation tend to show more persistent enhancement pattern than BRCA 1 mutation. Conclusion: In breast cancer patients with BRCA mutation, MRI didn’t show significant difference in morphologic characteristics,however breast cancers with BRCA gene mutation carriers tend to have benign morphologic features on MRI,such as Type 1 kinetic curve enhancement.
참고문헌 (16)
- Choi DH, "Incidence of BRCA1 and BRCA2 mutations in young Korean breast cancer patients", J Clin Oncol, 22, pp.1638~1645 (2004)
- Stratton MR, "Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases. Breast cancer linkage consortium", Lancet, 349, pp.1505~1510 (1997)
- Feig SA, "American college of radiology guidelines for breast cancer screening", AJR Am J Roentgenol, 171, pp.29~33 (1998)
- Burke W, "Recommendations for followup care of individuals with an inherited predisposition to cancer. Ii. BRCA1 and BRCA2. Cancer genetics studies consortium", JAMA, 277, pp.997~1003 (1997)
- Kriege M, "Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition", N Engl J Med, 351, pp.427~437 (2004)
- Kriege M, "MRI screening for breast cancer in women with familial or genetic predisposition: design of the Dutch National Study (MRISC)", Fam Cancer, 1, pp.163~168 (2001)
- Plevritis SK, "Cost-effectiveness of screening BRCA1", 2 mutation carriers with breast magnetic resonance imaging, 2006, pp.295, 2374~2384
- Warner E, "Comparison of breast magnetic resonance imaging, mammography, and ultrasound for surveillance of women at high risk for hereditary breast cancer", J Clin Oncol, 19, pp.3524~3531 (2001)
- Kuhl CK, "Breast MR imaging screening in 192 women proved or suspected to be carriers of a breast cancer susceptibility gene: preliminary results", Radiology, 215, pp.267~279 (2000)
- Saslow D, "American cancer society guidelines for breast screening with MRI as an adjunct to mammography", CA Cancer J Clin, 57, pp.75~89 (2007)
- Warner E, "Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination", JAMA, 292, pp.1317~1325 (2004)
- Veltman J, "Breast tumor characteristics of BRCA1 and BRCA2 gene mutation carriers on MRI", Eur Radiol, 18, pp.931~938 (2008)
- Schrading S, "Mammographic, US, and MR imaging phenotypes of familial breast cancer", Radiology, 246, pp.58~70 (2008)
- Blaichman J, "Sonographic appearance of invasive ductal carcinoma of the breast according to histologic grade", AJR Am J Roentgenol, 199, pp.W402~W408 (2012)
- Gilbert FJ, "Cancers in BRCA1 and BRCA2 carriers and in women at high risk for breast cancer: MR imaging and mammographic features", Radiology, 252, pp.358~368 (2009)
- 손병호, "한국인 유전성 유방암", Journal of Breast Cancer, 11(1), pp.1~9 (2008), 한국유방암학회