Correlation of the Speed of Enhancement of Hepatic Hemangiomas with Intravoxel Incoherent Motion MR Imaging
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Purpose : To evaluate the relationship between the speed of enhancement of hepatic hemangiomas on gadoliniumenhancedMRI and ADC values by using various parameters, including the D, f, D* and ADCfit on intravoxel incoherentmotion (IVIM) MR Imaging. Materials and Methods: The institutional review board approved this retrospective study. A total of 47 hepatic hemangiomasfrom 39 patients were included (20 men and 19 women). The hemangiomas were classified into three typesaccording to the enhancement speed of the hepatic hemangiomas on gadolinium-enhanced dynamic T1-weightedimages: rapid (Type A), intermediate (Type B), and slow (Type C) enhancement. The D, f, D* and ADCfit values were calculatedusing IVIM MR imaging. The diffusion/perfusion parameters and ADC values were compared among the three typesof hemangiomas. Results: Both the ADCfit and D values of type C were significantly lower than those of type A (P = 0.0022, P = 0.0085). However, for the f and D*, there were no significant differences among the three types. On DWI with all b values (50,200, 500 and 800 sec/mm2), the ADC values of type C were significantly lower than those of the type A (P < 0.012). For bvalues with 800 sec/mm2, the ADC800 values of the type C hemangiomas were significantly lower than those of type B (P= 0.0021). We found a negative correlation between hepatic hemangioma enhancement type and ADC50 (ρ= -0.357, P= 0.014), ADC200 (ρ= -0.537, P = 0.0001), ADC500 (ρ= -0.614, P = 0.0001), and ADC800(ρ= -0.607, P = 0.0001). Therefore, four ADC values of ADC50, ADC200, ADC500, and ADC800 were decreased with decreasing enhancementspeed. Conclusion: Hepatic hemangiomas had variable ADCs according to the type of enhancement, and the reduced ADCs inslowly enhancing hemangiomas may be related to the reduced pure molecular diffusion (D).
Abstract
Purpose : To evaluate the relationship between the speed of enhancement of hepatic hemangiomas on gadoliniumenhancedMRI and ADC values by using various parameters, including the D, f, D* and ADCfit on intravoxel incoherentmotion (IVIM) MR Imaging. Materials and Methods: The institutional review board approved this retrospective study. A total of 47 hepatic hemangiomasfrom 39 patients were included (20 men and 19 women). The hemangiomas were classified into three typesaccording to the enhancement speed of the hepatic hemangiomas on gadolinium-enhanced dynamic T1-weightedimages: rapid (Type A), intermediate (Type B), and slow (Type C) enhancement. The D, f, D* and ADCfit values were calculatedusing IVIM MR imaging. The diffusion/perfusion parameters and ADC values were compared among the three typesof hemangiomas. Results: Both the ADCfit and D values of type C were significantly lower than those of type A (P = 0.0022, P = 0.0085). However, for the f and D*, there were no significant differences among the three types. On DWI with all b values (50,200, 500 and 800 sec/mm2), the ADC values of type C were significantly lower than those of the type A (P < 0.012). For bvalues with 800 sec/mm2, the ADC800 values of the type C hemangiomas were significantly lower than those of type B (P= 0.0021). We found a negative correlation between hepatic hemangioma enhancement type and ADC50 (ρ= -0.357, P= 0.014), ADC200 (ρ= -0.537, P = 0.0001), ADC500 (ρ= -0.614, P = 0.0001), and ADC800(ρ= -0.607, P = 0.0001). Therefore, four ADC values of ADC50, ADC200, ADC500, and ADC800 were decreased with decreasing enhancementspeed. Conclusion: Hepatic hemangiomas had variable ADCs according to the type of enhancement, and the reduced ADCs inslowly enhancing hemangiomas may be related to the reduced pure molecular diffusion (D).
참고문헌 (24)
- Semelka RC, "Hepatic hemangiomas", Magn Reson Imaging Clin N Am, 5, pp.241~253 (1997)
- Ichikawa T, "Diffusion-weighted MR imaging with a single-shot echoplanar sequence: detection and characterization of focal hepatic lesions", AJR Am J Roentgenol, 170, pp.397~402 (1998)
- Namimoto T, "Focal liver masses: characterization with diffusion-weighted echoplanar MR imaging", Radiology, 204, pp.739~744 (1997)
- Taouli B, "Evaluation of liver diffusion isotrophy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences: prospective study in 66 patients", Radiology, 226, pp.71~78 (2003)
- Bruegel M, "Characterization of focal liver lesions by ADC measurements using a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging technique", Eur Radiol, 18, pp.477~485 (2008)
- Parikh T, "Focal liver lesion detection and characterization with diffusion weighted MR imaging:comparison with standard breath-hold T2-weighted imaging", Radiology, 246, pp.812~822 (2008)
- Taouli B, "Diffusion-weighted MR imaging of the liver", Radiology, 254, pp.47~66 (2010)
- Goshima S, "Hepatic hemangioma: correlation of enhancement types with diffusionweighted MR findings and apparent diffusion coefficients", Eur J Radiol, 70, pp.325~330 (2009)
- Vossen JA, "Receiver operating characteristic analysis of diffusion-weighted magnetic resonance imaging in differentiating hepatic hemangiomas from other hypervascular liver lesions", J Comput Assist Tomogr, 32, pp.750~756 (2008)
- Feuerlein S, "Pitfalls in abdominal diffusion weighted imaging: how predictive is restricted water diffusion for malignancy", AJR Am J Roentgenol, 193, pp.1070~1076 (2009)
- 남세진, "Hepatic Cavernous Hemangiomas: Relationship between Speed of Intratumoral Enhancement during Dynamic MRI and Apparent Diffusion Coefficient on Diffusion-Weighted Imaging", Korean Journal of Radiology, 13(6), pp.728~735 (2012), 대한영상의학회[DOI]
- Yamada I, "Diffusion coefficients in abdominal organs and hepatic lesions:evaluation with intravoxel incoherent motion echo-planar MR imaging", Radiology, 210, pp.617~623 (1999)
- Le Bihan D, "Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging", Radiology, 168, pp.497~505 (1988)
- Le Bihan D, "Effects of intravoxel incoherent motions (IVIM) in steady-state free precession (SSFP)imaging: application to molecular diffusion imaging", Magn Reson Med, 10, pp.324~337 (1989)
- Luciani A, "Liver cirrhosis: intravoxel incoherent motion MR imaging-pilot study", Radiology, 249, pp.891~899 (2008)
- Turner R, "Echo-planar imaging of intravoxel incoherent motions", Radiology, 177, pp.407~414 (1990)
- Dixon WT, "Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging: a modest proposal with tremendous potential", Radiology, 168, pp.566~567 (1988)
- Yoon JH, "Evaluation of hepatic focal lesions using diffusion-weighted MR imaging: comparison of apparent diffusion coefficient and intravoxel incoherent motion-derived parameters", J Magn Reson Imaging, 39, pp.276~285 (2014)
- Ichikawa S, "Intravoxel incoherent motion imaging of focal hepatic lesions", J Magn Reson Imaging, 37, pp.1371~1376 (2013)
- Patel J, "Diagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast enhanced MRI alone and in combination: preliminary experience", J Magn Reson Imaging, 31, pp.589~600 (2010)
- Koh DM, "Intravoxel incoherent motion in body diffusion-weighted MRI: reality and challenges", AJR Am J Roentgenol, 196, pp.1351~1361 (2011)
- Woo S, "Intravoxel incoherent motion diffusion-weighted MR imaging of hepatocellular carcinoma: correlation with enhancement degree and histologic grade", Radiology, 270, pp.758~767 (2014)
- Yu JS, "Intratumoral blood flow in cavernous hemangioma of the liver: radiologic-pathologic correlation", Radiology, 208, pp.549~550 (1998)
- Yamashita Y, "Cavernous hemangioma of the liver: pathologic correlation with dynamic CT findings", Radiology, 203, pp.121~125 (1997)