알코올 사용 장애자의 알코올 단서에 의해 유발된 갈망 특성
Alcohol Craving in Subjects with Alcohol Use Disorders in Response to Alcohol Cues
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약물에 대한 갈망은 중독적인 행동을 지속하는 데 있어 중요하다. 갈망은 강화적이거나 보상적인 약물을 복용하고자 하는 강한 욕구와 관련된 다차원적인 현상으로 여겨진다. 본 연구에서는 알코올 사용 장애자와 정상인이 알코올 관련 자극(소량의 술을 마시기, 알코올 관련 시각 자극)에 노출되었을 때 갈망에 대한 심리적인 반응의 차이를 밝히고자 하였다. 알코올 관련 시각 자극을 개발하기 위하여 Normative Appetitive Picture System(NAPS)과 1차 집단 심리 실험을 통하여 알코올 자극을 선정하고 자극의 적합성과 효과성을 검증하여 자극을 최종 개발하였다. 본 실험을 위해 알코올 사용 장애를 가진 9명의 남녀 대학생(남：8명)과 9명의 비의존 남녀 대학생(남：8명)을 선정하였다. 실험참여자는 5cc 정도의 알코올을 복용하고, 알코올 자극, 음료 자극, 통제 자극(흐릿하게 변형된 알코올 자극)과 고정점 자극(십자가 기호)에 무선적으로 노출되었으며, 각 종류의 자극이 제시되고 나면 마우스를 이용하여 심리적 갈망 수준을 보고하였다. 심리반응 결과, 강박음주갈망척도, 음주 전, 음주 후 알코올 갈망에서 두 집단 간 유의한 차이가 나타났다. 알코올 사용 장애 집단은 알코올 자극을 포함한 모든 자극에서 정상인 집단보다 높은 알코올 갈망 수준을 나타내었다. 결론적으로 알코올 사용 장애자는 알코올 자극에 의해 유발된 심리적 갈망이 정상인과 다른 것으로 나타났다.
Abstract
Initially, this study was to develop reliable and effective alcohol-associated visual cues. Alcoholic picture cues were chosen from the Normative Appetitive Picture System (NAPS). Additional images consisted of Korean beer and mild liquor was pre-tested to select the pictures that would induce craving most intensely. The images that recorded the highest scores on a scale were chosen through the pre-test. And then, the reliability and validity were examined for the selected alcohol cues from NAPS and pre-test via another psychometric test. Secondly, the study was to investigate differences in craving between subjects with alcohol use disorders (AUDs) and non-alcoholic control subjects when exposed to the alcohol visual cues. Alcohol abusers with AUD (n=9) and demographically similar non-abusers (n=9) participated in this study. After given 5cc of alcohol, subjects were exposed to different types of stimuli (i.e., alcohol, nonalcoholic beverage, and visual control pictures and one rest (cross-hair)). Craving levels were rated through self-report on a Likert scale immediately after the presentation of visual cues. Results showed statistically significant differences between the AUD group and the control group in the Obsessive Compulsive Drinking Scale (OCDS) scores, pre-sip and post-sip alcohol craving. Also, the AUD group showed significantly a higher level of craving during alcohol cues compared to the control group. In conclusion, alcohol craving induced by alcohol cues among subjects with AUD was found to be different from that of non-abusers.
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