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돼지 황체에서 황체용해와 대식세포와의 관계

A Morphological Study on the Macrophages During Luteolysis in the Pig

박창식|양윤석|김원식|한승로|손성경
한국축산학회 (Korean Society of Animal Sciences and Technology)|2006.04|한국축산학회지 (Journal of Animal Science and Technology)|제48권 제2호|pp. 191-202

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참고문헌

주제분류축산학

초록

황체내에서 대식세포는 자신이 분비하는 사이토카인을 통해 황체형성기에는 황체형성세포들의 증식과 성장에 관여하고 황체용해시기에는 황체세포들의 아포토시스와 그들의 제거에 직간접적으로 관여하는 것으로 알려져 있다. 본 실험에서는 돼지에서 최대성숙황체 시기와 황체의 용해에 따른 대식세포의 역할과 작용기전 등을 알아보기 위해 면역조직화학적 및 투과전자현미경적 방법으로 황체의 형태학적 변화를 관찰하였다. 그 결과 돼지에서는 황체용해시에 아포토시스 소체들을 포식하는 대식세포들이 관찰되지 않았고, 최대 황체시기와 황체용해시기에 대식세포들은 미세구조와 그것들이 위치하는 부위가 각기 다른 2가지 아형들이 관찰되었다. 이같은 결과로 볼 때, 돼지에서는 황체용해시 아포토시스 소체들이 대식세포의 포식작용에 의하지 않고 자체 혈관을 통해 제거되는 것으로 보이며, 황체에는 각 시기별로 각기 다른 임무를 띤 아형의 대식세포들이 혈류로부터 들어와 시기특이적으로 작용하는 것으로 추정된다.

Abstract

In addition to the removal of dying or dead lutein cells by phagocytosis in many species, macrophages exert both luteotropic effect during maturation period and luteolytic effect during degenerative period via mediating autocrine/paracrine actions of self-producing cytokines in the corpus luteum. In this experiment, immunohistochemical and transmission electron microscopic (TEM) studies were performed to observe the morphologic changes of luteal macrophages during luteolysis. A small number of macrophages and low immunoreactivity were present at the mature stage. The number of macrophages and immunoreactivity gradually increased along the advance of luteolysis. Two subtypes of macrophages could be observed through TEM observation. One type of macrophage located between the large lutein cells contained no lipid droplets in their cytoplasm at mature stage. The other type of macrophage located near the blood vessels contained many lipid droplets in their cytoplasm during luteolysis. Particularly, no phagocytic macrophages were observed, which suggested the macrophages in the porcine corpus luteum did not involve in the phagocytotic elimination of dying lutein cells.

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