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황기의 알러지 비염 동물실험에 대한 면역조절 효과

Immuno Modulatory Effect of Astragali Radix on OVA Induced Allergic Mouse Model

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참고문헌

주제분류한의학

초록

Abstract

Astragali Radix(AR), is a popular tonic herb prescribed for “insufficient qi” in Korea, Japan and China. The present study examined the effect of AR ethanol extract on ovalubumin induced allergic mouse model. AR administration reduced levels of IFN-gamma, Interleukin(IL)-4, IL-5 and total IgE in the OVA induced allergic inflammation. It also protected the upper airway respiratory epithelium from being damaged by the OVA induced inflammation. Taken together, our results showed that the use of AR alone proved to down-regulate Th1 and Th2 cytokine production and play a protective role in tissue damage in allergic disease.

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