자음양영탕이 Streptozotocin(STZ)로 유발된 생쥐의 고혈당에 미치는 影響
Effect of Jaeumyangyung-tang on the Hyperglycemic Mice Induced with Streptozotocin
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Abstract
Objectives : The aim of this study was to investigate the effect of Jaeumyangyung-tang (滋陰養榮湯(JY), JA-0.65g/kg; JB-1.3g/kg) on hyperglycemic mice induced with streptozotocin(STZ). Methods : The experiment operated for 6 weeks. The rats were divided into 3 groups : diabetic group(control group), diabetic group treated with JA(0.65g/kg) for 6 weeks, and diabetic group treated with Jb(1.3g/kg) for 6 weeks.Results : In the STZ-induced diabetic group, blood glucose levels significantly increased as well as the loss of body weight. The levels of serum glucose decreased significantly (p<0.05 or p<0.01) in the JA and JB groups compared with the control. According to a tolerance test, intraperitoneal glucose was ameliorated in the JA and JB groups. The blood urea nitrogen (BUN) and creatinine levels slightly decreased. Histologic analyses of the pancreases revealed that the β-cells on Langerhans’ islets were destroyed by STZ, but the β-cell mass was larger in the JY than in the control mice.Conclusions : These results indicate that JY can exert beneficial effects on diabetes, preservation of in vivo β-cell function and regeneration of β-cell dysfunction by STZ.
참고문헌 (22)
- "임상 내분비학", pp.349~ (1999), 고려의학
- "실용중의내과학", pp.48~ (1996), 상해과학기술출판사
- "Effects of Korean Ginseng on metabolism of glucose in rats", pp.158~65 (1977)
- "Effect of Rehmanniae Radix and Pear phenolic compound on the STZ-treated mice for induction of diabetes", 33(1), pp.66~71 (2004)
- "Streptozotocin으로 유발된 당뇨백서에서 수종의 한약재가 혈당강하에 미치는 영향", 18(2), pp.21~27 (2003)
- "肺消의 치료에 관한 문헌적 고찰", 2(1), pp.63~73 (1996)
- "Effects of Rhois Galla extract on pancreatic glucokinase and hexokinase activities of interleukin-1β-induced diabetes mellitus mice", 7(1), pp.65~74 (1998)
- "生地黃飮子加味가 STZ으로 유발된 당뇨생쥐에 미치는 영향", 26(1), pp.12~47 (2005)
- "청폐사간탕이 STZ으로 유발된 흰쥐의 실험적 당뇨에 미치는 영향", 11(1), pp.244~245 (1997)
- "소갈의 전병증과 당뇨병의 만성합병증에 대한 비교고찰", 19(2), pp.137~152 (1998)
- "備急千金要方", pp.530~ (1984), 大星文化社
- "消渴의 病因病機와 鍼灸治療에 관한 문헌적 고찰", 4(1), pp.269~285 (1995)
- "Necrosis of Langerhans produced experimentally", lancet ι, pp.484~7 (1943)
- "당뇨병 흰쥐에서 식이 제한 급여가 장기의 항산화효소 활성도 및 체중에 미치는 영향", 30(3), pp.521~527 (2001)
- "Alloxan 유발 당뇨 생쥐에 미치는 Evening Primrose 종자유의 영향", 9, pp.113~123 (1988)
- "임상 신장학", pp.100~ (1992), 계명대학교 출판부
- "전정판 증상별 임상검사", pp.500~ (1997), 서울대학교 출판부
- "Effect of chronic treatment with losartan on streptozotocin induced diabetic nephropathy", 23, pp.513~520 (2001)
- "An Immunohistochemical Study of Macrophage Influx and the Colocalization of Inducible Nitro Oxide Synthase in the pancreas of Non-obese Diabetic(NOS) Mice During Disease Acceleration with Cyclophosphamide", 31(5), pp.303~314 (1999)
- "Effects of aging on the regenerative capacity of the pancreatic β-cell of rat", diabetes 32, pp.14~9 (1983)
- "Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells", 6, pp.278~282 (2000)
- "Islet growth and development in the adult", 24, pp.297~302 (2000)