본문 바로가기
KERD
논문KCI 등재

生津養血湯 물 추출물의 Streptozotocin 유발 고지혈증에 대한 효과

Hypolipemic Effect of “Saengjinyanghyul-tang” water extracts in the Streptozotocin-induced Hyperlipemic SD Rat.

1

조회

0

다운로드

3

인용

0

참고문헌

주제분류한의학

초록

Abstract

In the present study, the therapeutic hypolipemic effect of water extract of Saengjinyanghyul-tang (SJYHT), a herbal extract mixture for treatment of diabetes in oriental medicine was tested in Streptozotocin-induced diabetic hyperlipemic SD rats. For detect the therapeutic effects, the test articles were once a day dosed for 28 days by gastric gavage at a dosage 1000, 500 and 250㎎/㎏from 25 days after STZ-dosing, and the changes on body weight and gains, serum LDL, HDL, Triglyceride and Total Cholesterol levels were observed. In addition, the effects of test articles were compared to that of Simvastatin, a well known hypolipemic agents 10㎎/㎏-dosing group. Base on these results, although no meaningful effects were detected on the serum HDL levels, it is concluded that Saengjinyanghyul-tang water extracts have relatively good favorable effect treatment of STZ-induced diabetic hyperlipemia because they showed clear evidences inhibit the increase of serum LDL, Triglyceride and Total Cholesterol levels. Therefore, it is expected that Saengjinyanghyul-tang extract has favorable potency to development hypolipemic drugs. In addition, about 1000㎎/㎏ of Saengjinyanghyul-tang extracts have similar effect compared to that of Simvastatin 10㎎/㎏. The effective dosage of Saengjinyanghyul-tang water extracts in the present study was considered as below 250㎎/㎏.

참고문헌 (37)

  1. "Anti diabetic activity of the semi purified fractions of Averrhoa bilimbi in high fat diet fed streptozotocin induced diabetic rats", 76, pp.2827~2839 (2005)
  2. "Antidiabetic effect of Boerhavia diffusa effect on serum and tissue lipids in experimental diabetes", 7, pp.472~476 (2004)
  3. "Clinical trial of Cecropia obtusifolia and Marrubium vulgare leaf extracts on blood glucose and serum lipids in type 2 diabetics Phytomedicine", 11, pp.561~566 (2004)
  4. "Experimental study on preventive effect of Radix Paeoniae Rubra to restenosis after carotid balloon injury in high fat diet rabbits Zhongguo Zhong Xi Yi Jie He Za Zhi", 24, pp.538~540 (2004)
  5. "Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats", 48, pp.123~128 (2004)
  6. "Hypolipidemic activity of seeds of Cassia tora Linn", 90, pp.249~252 (2004)
  7. "Cholesterol lowering effect of a theaflavin enriched green tea extract a randomized controlled trial", 163, pp.1448~1453 (2003)
  8. "Hypolipidemic activity of Acorus calamus L", 73, pp.451~455 (2002)
  9. "A water extract of the Korean traditional formulation Geiji Bokryung Hwan reduces atherosclerosis and hypercholesteremia in cholesterol fed rabbits", 3, pp.723~734 (2003)
  10. "Attenuation of hyperglycemia and hyperlipidemia in streptozotocin induced diabetic rats by aqueous extract of seed of Tamarindus indica", 28(7), pp.1172~1176 (2005)
  11. "고혈당 쥐의 간 대사효소계에 미치는 생진양혈탕(生津養血湯)의 영향", 16(2), pp.320~336 (1995)
  12. "생진양혈탕(生津養血湯)이 고혈당 쥐의 혈중지질성분에 미치는 영향", 16(2), pp.337~347 (1995)
  13. "고혈당 쥐의 췌장(膵臟) 효소활성에 미치는 생진양혈탕(生津養血湯)의 영향", pp.429~444 (1995)
  14. "Role of hyperlipidemia in progressive renal disease focus on diabetic nephropathy", 71, pp.31~36 (1999)
  15. "Nitrotyrosine new findings as a marker of postprandial oxidative stress", 129, pp.51~58 (2002)
  16. "Simvastatin combined with ramipril treatment in hypercholesterolemic patients", 44(2), pp.180~185 (2004)
  17. "Effectiveness of simvastatin therapy in raising HDL C in patients with type 2 diabetes and low HDL C", 20(7), pp.1087~1094 (2004)
  18. "Anti-oxidative effect of fluvastatin in hyperlipidemic type 2 diabetic patients", 52(2), pp.259~264 (2005)
  19. "Anti diabetic activity of Zingiber officinale in streptozotocin induced type I diabetic rats", 56(1), pp.101~105 (2004)
  20. "Quercetin an anti oxidant bioflavonoid attenuates diabetic nephropathy in rats", 31(4), pp.244~248 (2004)
  21. "Effects of Nigella sativa on oxidative stress and beta cell damage in streptozotocin induced diabetic rats", 279(1), pp.685~691 (2004)
  22. "Studies on anti hyperglycemic effect and its mechanism of Dendrobium candidum", 29(2), pp.160~163 (2004)
  23. "Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats", 97(2), pp.227~230 (2005)
  24. "Antihyperglycemic effect of polysaccharide from fermented broth of Pleurotus citrinopileatus", 7, pp.1~7 (2005)
  25. "Increasing high density lipoprotein cholesterol in dyslipidemia by cholesteryl ester transfer protein inhibition:an update for clinicians", 111, pp.1847~1854 (2005)
  26. "Hypolipidemic and antioxidant properties of tocotrienol rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats", 43, pp.747~753 (2005)
  27. "Effects of ginsenoside Rb on blood lipid metabolism and anti oxidation inhyperlipidemia rats Zhongguo Zhong Yao Za Zhi", 9, pp.1085~1088 (2004)
  28. "The effect of simvastatin associated with ranitidine and alcohol upon serum lipids", 42, pp.143~148 (2004)
  29. "Effects of statin treatment on uric acid homeostasis in patients with primary hyperlipidemia", 148, pp.635~640 (2004)
  30. "Bovine growth hormone transgenic mice are resistant to diet induced obesity but develop hyperphagia and diabetes on a high fat diet", 146, pp.920~930 (2005)
  31. "Hypolipidemic effect of Glycine tomentella root extract in hamsters", 32, pp.57~63 (2004)
  32. "The effects of bitter melon Momordica charantia on serum and liver triglyceride levels in rats", 91, pp.257~262 (2004)
  33. "Amaranth squalene reduces serum and liver lipid levels in rats fed a cholesterol diet", 61, pp.11~14 (2004)
  34. "Eradication of Helicobacter pylori increases the incidence of hyperlipidaemia and obesity in peptic ulcer patients", 37, pp.39~43 (2005)
  35. "Meta analysis of the effects of soy protein containing isoflavones on the lipid profile", 81, pp.397~408 (2005)
  36. "Comparison of the effects of dietary plant sterol and stanol esters on lipid metabolism", 14, pp.133~142 (2004)
  37. "Cholesterol lowering effect of SG GN3 the extract of salted and fermented small shrimps in Triton WR1339 or high cholesterol diet induced hypercholesterolemic rats", 91, pp.231~235 (2004)

관련 논문AI추천

이 간행물의 다른 논문 (23건)