경도인지장애 침치료 인지기능효과 : 체계적 문헌고찰 메타분석
Cognitive Function Effects of Acupuncture Treatment for Mild Cognitive Impairment : Systematic Literature Review and Meta-Analysis
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초록
목적 : MMSE와 MoCA 인지 도구를 사용하여 인지유형에 따른 침치료 효과를 확인하고자 하였다. 체계적 문헌 고찰을 통하여 침치료 적용 방법에 따라 효과성과 침치료 무작위 임상시험 논문의 질을 평가하여 임상시험 논문의 편향성을 파악하고자 하였다. 방법 : 2012년에서 2023년까지 수행된 경도인지장애 침치료 효과에 대한 논문을 문헌고찰과 코크란 메타분석으로 조사한 연구이다. 논문 질 분석도구는 코크란 편향성 위험도구(Cochrane risk of bias : RoB)를 사용하였으며 메타분석 도구는 메타분석용 Cochrane RevMan V5.4.1 (Cochrane Collaboration) 소프트웨어를 사용하였다. 결과 : 분석에 사용한 대상자는 총 967명으로 침치료 무작위 대조군 연구논문 16편이 분석되었다. 결과는 다음과 같다. 경도인지장애 침치료 메타분석 결과 MMSE 평균차이는 1.61로 95% 신뢰구간은 0.14에서 3.07로 p〈0.001로 유의하였다. Z=2.15(p=0.03), MoCA 점수는 평균차이는 0.39에서 2.49로 p<0.001), Z=2.70(p=0.007)로 경도인지장애 대상자의 침치료 효과는 유의하였다. 결론 : 경도인지장애 침치료 효과는 유의하였으며, 향후 다양한 유형의 경도인지장애 침치료 무작위대조군 연구를 제안하고자 한다. 이 연구의 의의는 지역사회 경도인지장애 대상자의 예방적 차원의 융합인지 중재프로그램개발의 기초자료를 제시하였다는데 의의가 있다.
Abstract
Objectives : Using MMSE and MoCA cognitive tools, this study tried to measure the effect of acupuncture differing by cognitive types. Through the method of PRISMA literature review, this study aimed to understand and improve the acupuncture’s effectiveness in its application. Methods : The research method was a literature review and Cochrane meta-analysis of papers on the effectiveness of acupuncture treatments for mild cognitive impairment conducted from 2012 to 2023. The Cochrane risk of bias (RoB) tool was used as a quality analysis tool, and the meta-analysis tool was Cochrane RevMan V5.4.1 software. Results : As a result of the study, a total of 967 subjects were used for analysis, and 16 papers on randomized acupuncture trials were analyzed. The results are as follows: As a result of meta-analysis of acupuncture intervention for mild cognitive impairment, the MMSE score had an average of 1.61 with a 95% confidence interval ranging from 0.14 to 3.07, and a statistically significant result with p<0.001. The Z-score was 2.15, which corresponded to a p-value of 0.03. The MoCA score had an average range between 0.39 and 2.49, also showing statistical significance with p<0.001, and a Z-score of 2.70 (p=0.007). The effect of acupuncture in subjects with mild cognitive impairment was significant. Conclusion : The suggestions and conclusion indicate that acupuncture intervention has a significant effect on mild cognitive impairment. This study propose future experimental research on various types of acupuncture interventions for mild cognitive impairment. The significance of this study is that it presented basic data for the development of a preventive convergence cognitive intervention program for patients with mild cognitive impairment in the community.
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