한의의료기관 종사자의 잠복결핵감염 유병규모 및 위험인자
Prevalence size and risk factors for latent tuberculosis infection among Korean Medicine workers
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Background : Tuberculosis (TB) remains a significant public health issue worldwide, particularly among healthcare workers (HCWs) at high risk of exposure. Latent tuberculosis infection (LTBI) is a state where individuals are infected with Mycobacterium tuberculosis but do not show clinical symptoms. Early detection and treatment of LTBI are crucial to prevent progression to active TB. This study aimed to investigate the prevalence and risk factors of LTBI among Korean Medicine (KM) workers in Seoul, South Korea. Methods : This study analyzed 368 adults aged 19 and over working in Korean medicine institutions in Seoul by September 2023. Participants underwent a tuberculin skin test (TST) and completed a survey collecting demographic information, occupation, work duration, smoking status, BCG vaccination, TB history, and comorbidities. Data were analyzed using descriptive statistics and chi-square tests, with significance set at p < 0.05. Results : The average age of participants was 43.1 years, with an LTBI prevalence rate of 3.5%. Significant risk factors included age and history of TB, Older age and a history of TB were associated with higher LTBI positivity. Conclusion : The study identified the prevalence and risk factors of LTBI among Korean medicine workers in Seoul. The findings highlight the need for targeted LTBI screening and preventive measures, especially for older workers and those with a history of TB. While the prevalence was lower than in other healthcare settings, the results emphasize the importance of regular LTBI testing and prevention education for KM workers. Future large-scale studies are needed to confirm these findings and further understand the relationship between various risk factors and LTBI in KM settings.
Abstract
Background : Tuberculosis (TB) remains a significant public health issue worldwide, particularly among healthcare workers (HCWs) at high risk of exposure. Latent tuberculosis infection (LTBI) is a state where individuals are infected with Mycobacterium tuberculosis but do not show clinical symptoms. Early detection and treatment of LTBI are crucial to prevent progression to active TB. This study aimed to investigate the prevalence and risk factors of LTBI among Korean Medicine (KM) workers in Seoul, South Korea. Methods : This study analyzed 368 adults aged 19 and over working in Korean medicine institutions in Seoul by September 2023. Participants underwent a tuberculin skin test (TST) and completed a survey collecting demographic information, occupation, work duration, smoking status, BCG vaccination, TB history, and comorbidities. Data were analyzed using descriptive statistics and chi-square tests, with significance set at p < 0.05. Results : The average age of participants was 43.1 years, with an LTBI prevalence rate of 3.5%. Significant risk factors included age and history of TB, Older age and a history of TB were associated with higher LTBI positivity. Conclusion : The study identified the prevalence and risk factors of LTBI among Korean medicine workers in Seoul. The findings highlight the need for targeted LTBI screening and preventive measures, especially for older workers and those with a history of TB. While the prevalence was lower than in other healthcare settings, the results emphasize the importance of regular LTBI testing and prevention education for KM workers. Future large-scale studies are needed to confirm these findings and further understand the relationship between various risk factors and LTBI in KM settings.
참고문헌 (37)
- Global tuberculosis report 2023, "World Health Organization", World Health Organization, ~ (2023)
- Korea Disease Control and Prevention Agency, Tuberculosis Policy Division, "2024 National Tuberculosis Control Guidelines", Korea Centers for Diseases Control and Prevention Agency, ~ (2024)
- Latent Tuberculosis Infection: Updated and Consolidated Guidelines for Programmatic Management, "World Health Organization", World Health Organization, ~ (2018)
- Corbett EL, "Nursing and community rates of Mycobacterium tuberculosis infection among students in Harare, Zimbabwe", Clin Infect Dis, 44(3), pp.317~323 (2007)
- Szturmowicz M, "Prevalence and Risk Factors for Latent Tuberculosis in Polish Healthcare Workers : The Comparison of Tuberculin Skin Test and Interferon-Gamma Release Assay(IGRA)Performance", J Occup Med Toxicol, 16, pp.38~49 (2021)
- Yang H, "Factors Influencing the Initiation and Adherence of LTBI Treatment in Healthcare Workers : A Systematic Review", Arch Environ Occup Health, 77(1), pp.76~85 (2022)
- Uden L, "Risk of Tuberculosis Infection and Disease for Health Care Workers : An Updated Meta-Analysis", Open Forum Infect Dis, 4(3), pp.ofx137~ (2017)
- Jeon D, "Latent Tuberculosis Infection : Recent Progress and Challenges in South Korea", Korean J Intern Med, 35(2), pp.269~283 (2020)
- Kim S, "Prevalence of and Factors Related to Latent Tuberculous Infection among all Employees in a Referral Hospital", Int J Tuberc Lung Dis, 22(11), pp.1329~1335 (2018)
- Yeon JH, "Prevalence and Risk Factors of Latent Tuberculosis among Korean Healthcare Workers using Whole-Blood Interferon-γ Release Assay", Sci Rep, 8(1), pp.10113~ (2018)
- Park JS, "The Prevalence and Risk Factors of Latent Tuberculosis Infection among Health Care Workers Working in a Tertiary Hospital in South Korea", Tuberc Respir Dis(Seoul), 81(4), pp.274~280 (2018)
- Kim SY, "Tuberculin Skin Test and Boosted Reactions among Newly Employed Healthcare Workers : An Observational Study", PLoS One, 8(5), pp.e64563~ (2013)
- Min J, "Latent Tuberculosis Cascade of Care among Healthcare Workers : A Nationwide Cohort Analysis in Korea between 2017 and 2018", J Korean Med Sci, 37(20), pp.e164~ (2022)
- Lee JB, "Analysis of Prevalence and Risk Factors for Latent Tuberculosis Infection among Healthcare Workers", J Korean Biol Nurs Sci, 21(4), pp.300~308 (2019)
- Lee S, "Prevalence and risk factors of latent tuberculosis infection among healthcare workers", Korean J Healthc Assoc Infect Control Prev, 24(2), pp.52~59 (2019)
- Kim YJ, "In-Hospital Contact Investigation among Health Care Workers After Exposure to Pulmonary Tuberculosis in an Intermediate Tuberculosis Prevalence Area : A Prospective Study", Arch Environ Occup Health, 72(2), pp.112~118 (2017)
- Getahun H, "Latent Mycobacterium tuberculosis infection", N Engl J Med, 372(22), pp.2127~2135 (2015)
- Carranza C, "Diagnosis for Latent Tuberculosis Infection : New Alternatives", Front Immunol, 11, pp.2006~ (2020)
- Smith R, "Interferon-γ release assays for diagnosis of latent tuberculosis infection : evidence in immune-mediated inflammatory disorders", Curr Opin Rheumatol, 23(4), pp.377~384 (2011)
- Loureiro RB, "Cost-effectiveness of QuantiFERON-TB Gold in-tube versus tuberculin skin test for diagnosis and treatment of latent tuberculosis infection in primary health care workers in Brazil", PLoS One, 14(11), pp.e0225197~ (2019)
- Zwerling A, "Interferongamma release assays for tuberculosis screening of healthcare workers : a systematic review", Thorax, 67(1), pp.62~70 (2012)
- Mattos de Souza F, "Comparison of Interferon-γRelease Assay to Two Cut-Off Points of Tuberculin Skin Test to Detect Latent Mycobacterium tuberculosis Infection in Primary Health Care Workers", PLoS One, 9(8), pp.e102773~ (2014)
- Sterling TR, "Three months of rifapentine and isoniazid for latent tuberculosis infection", N Engl J Med, 365(23), pp.2155~2166 (2011)
- Casas I, "Serial testing of health care workers for tuberculosis infection : a prospective cohort study", PLoS One, 15(7), pp.e0235986~ (2020)
- Rangaka MX, "Predictive value of interferon-γ release assays for incident active tuberculosis : a systematic review and metaanalysis", Lancet Infect Dis, 12(1), pp.45~55 (2012)
- Arguello Perez E, "Management of Latent Tuberculosis Infection Among Healthcare Workers : 10-Year Experience at a Single Center", Clin Infect Dis, 65(12), pp.2105~2111 (2017)
- Kunst H, "Age-related risk of hepatotoxicity in the treatment of latent tuberculosis infection : a systematic review", Int J Tuberc Lung Dis, 14(11), pp.1374~1381 (2010)
- Zhang X, "Prevalence and Risk Factors for Latent Tuberculosis Infection among Health Care Workers in China : A Cross-Sectional Study", PLoS One, 8(6), pp.e66412~ (2013)
- Diefenbach-Elstob TR, "Risk of latent and active tuberculosis infection in travellers: a systematic review and meta-analysis", J Travel Med, 28(2), pp.taaa 214~ (2021)
- Diel R, "Risk of tuberculosis transmission by healthcare workers to children-a comprehensive review", Pneumologie, 74(12), pp.758~770 (2020)
- Cho Y, "A retrospective descriptive study on the status of active tuberculosis among healthcare workers in a tertiary hospital", Korean J healthc assoc Infect Control Prev, 26(2), pp.89~95 (2021)
- Jo K, "Prevalence of latent tuberculosis infection among health care workers in south korea : A multicenter study", Tuberc Respir Dis, 75, pp.18~24 (2013)
- Youssef E, "Serious allergic reactions following tuberculin skin tests", Canadian Medical Association Journal, 173(1), pp.34~ (2005)
- Whitaker JA, "Prevalence and incidence of latent tuberculosis infection in georgian healthcare workers", PLoS ONE, 8(3), pp.e58202~ (2013)
- Nasreen S, "Prevalence of Latent Tuberculosis among Health Care Workers in High Burden Countries : A Systematic Review and Meta-Analysis", PLoS One, 11(10), pp.e0164034~ (2016)
- Apriani L, "Latent tuberculosis infection in healthcare workers in low-and middle-income countries : an updated systematic review", Eur Respir J, 53(4), pp.1801789~ (2019)
- Mongkolrattanothai T, "Tuberculosis among healthcare personnel, United States, 2010-2016", Infect Control Hosp Epidemiol, 40(6), pp.701~704 (2019)