본문 바로가기
KERD
논문KCI 등재

지역사회 거주 경도인지장애 노인들을 대상으로 시행한한의치료의 보고: 인지기능을 중심으로

Results of Korean Medicine Treatment in Community Dwelling Elderly with Mild Cognitive Impairment: Focusing on the Change in Cognitive Ability

2

조회

0

다운로드

2

인용

0

참고문헌

키워드

주제분류한의학

초록

Objectives: The purpose of this study was to identify the effectiveness of Korean medicine treatment in mild cognitive impairment (MCI) among a group of community dwelling elderly. Methods: Two-hundred and twenty-nine elderly living in a community and diagnosed with MCI were recruited. Participants were evaluated with various instruments such as the Korean version of Mini- Mental State Examination for Dementia Screening (MMSE-DS) and the Korean version of Montreal Cognitive Assessment (MoCA-K). Korean medicine treatment consisted of herbal medicine, acupuncture, and pharmacoacupuncture. The change in cognitive ability was assessed by using the MMSE-DS and the MoCA-K. Data were analyzed by SPSS/WIN 22.0 using the paired t-test, and the ANOVA. Results: The MMSE-DS and the MoCA-K score generally increased after six months of Korean medicine treatment and the differences in both instruments were statistically significant. Additionally, some consecutive participants maintained long-term cognitive improvement. When analyzed specifically by herbal medicine group based on syndrome differentiation and pharmacoacupuncture group, most showed improvement in the MMSE-DS and the MoCA-K but not all data were statistically significant. The satisfaction score was mostly high and most participants were willing to re-participate in the program. Conclusions: Korean medicine treatment may contribute to the improvement and prevention of cognitive decline in the elderly. However, further systematic research based on large scale sample data and standardized protocols is needed to uplift the welfare and mental health of the elderly.

Abstract

Objectives: The purpose of this study was to identify the effectiveness of Korean medicine treatment in mild cognitive impairment (MCI) among a group of community dwelling elderly. Methods: Two-hundred and twenty-nine elderly living in a community and diagnosed with MCI were recruited. Participants were evaluated with various instruments such as the Korean version of Mini- Mental State Examination for Dementia Screening (MMSE-DS) and the Korean version of Montreal Cognitive Assessment (MoCA-K). Korean medicine treatment consisted of herbal medicine, acupuncture, and pharmacoacupuncture. The change in cognitive ability was assessed by using the MMSE-DS and the MoCA-K. Data were analyzed by SPSS/WIN 22.0 using the paired t-test, and the ANOVA. Results: The MMSE-DS and the MoCA-K score generally increased after six months of Korean medicine treatment and the differences in both instruments were statistically significant. Additionally, some consecutive participants maintained long-term cognitive improvement. When analyzed specifically by herbal medicine group based on syndrome differentiation and pharmacoacupuncture group, most showed improvement in the MMSE-DS and the MoCA-K but not all data were statistically significant. The satisfaction score was mostly high and most participants were willing to re-participate in the program. Conclusions: Korean medicine treatment may contribute to the improvement and prevention of cognitive decline in the elderly. However, further systematic research based on large scale sample data and standardized protocols is needed to uplift the welfare and mental health of the elderly.

참고문헌 (49)

  1. "Population Projection: 2010-2060"[URL]
  2. Elizabeth, L. G., "Brain aging: models, meth-ods, and mechanisms: An annual review", pp.1~9 (2007), CRC Press
  3. Hong CM, "A study on dementia and mild cognitive im-pairment", The Korea Contents Society, 6, pp.25~30 (2012)
  4. Choi KG, "Neuropathology of MCI-View from Relation-ships with Aging and Alzheimer’s Disease-", Dementia and Neurocognitive Disorders, 2(2), pp.101~107 (2003)
  5. Larrieu, S., "Incidence and outcome of mild cognitive impairment in a population-based pro-spective cohort", Neurology, 59(10), pp.1594~1599 (2002)
  6. National Institute of Dementia, "Korean Dementia Obser-vatory 2018", ~
  7. 이정배, "한국 치매 환자의 건강보험 의ㆍ한의 진료 비용에 관한 연구", 동의신경정신과학회지, 30(1), pp.31~38 (2019), 대한한방신경정신과학회[DOI]
  8. Petersen RC, "Practice parameter: Early detection of dementia: Mild cognitive impairment (an evi-dence-based review)", Neurology, 56, pp.1133~1142 (2001)
  9. J. Birks, "Donepezil for mild cognitive impairment", Cochrane Database of Systematic Reviews, 3 (2006)
  10. H. H. Feldman, "Effect of riva-stigmine on delay to diagnosis of Alzheimer’s disease from mild cognitive impairment: the InDDEx study", The Lancet Neurology, 6(6), pp.501~512 (2007)
  11. Petersen RC, "Vitamin E and donepezil for the treatment of mild cognitive impairment", N Engl J Med, 352(23), pp.2379~2388 (2005)
  12. Feldman HH, "Effect of rivastigmine on delay to diagnosis of Alzheimer’s disease from mild cognitive impairment: the InDDEx study", Lancet Neurol, 6(6), pp.501~512 (2007)
  13. Barnes DE, "Computer -based cognitve training for mild cognitive impairment:Results from a pilot random-ized, Controlled Trial", Alzheimer Dis Assoc Disord, 23(3), pp.205~210 (2009)
  14. Van Uffelen JG, "Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomised controlled trial", Br J Sports Med, 45(5), pp.344~351 (2008)
  15. 김경윤, "한국 경도인지장애 노인을 위한 인지기능 향상 프로그램의 효과: 메타분석", 성인간호학회지, 29(2), pp.177~189 (2017), 한국성인간호학회[DOI]
  16. "Center for prevention of Stroke and Dementia"[URL]
  17. Ihl R, "World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treat-ment of Alzheimer’s disease and other dementias", World J Biol Psychiatry, 12(1), pp.2~32 (2011)
  18. 윤현철, "치매의 약물요법", 대한의사협회지, 61(12), pp.758~764 (2018), 대한의사협회[DOI]
  19. Arai M, "The Effectiveness of the Japanese Kampo Medicine, Kamikihito, for the Cognitive Impair-ment of Dementia", Int Med J, 22(3), pp.175~177 (2015)
  20. Iwasaki K, "A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of the Chinese Herbal Medicine “Ba Wei Di Huang Wan”± in the Treatment of Dementia", J Am Geriatr Soc, 52(9), pp.1518~1521 (2004)
  21. 김민욱, "Systematic Review of Acupuncture Treatment for Mild Cognitive Impairment", Journal of Acupuncture Research, 36(2), pp.72~79 (2019), 대한침구의학회[DOI]
  22. Kwon CY, "Efficacy and Safety of Auricular Acupuncture for Cognitive Impair-ment and Dementia: A Systematic Review", Review. Evidence-Based Complementary and Alternative Medicine (2018)
  23. 김우영, "경도인지장애의 비약물요법에 대한 고찰", 동의신경정신과학회지, 22(3), pp.1~11 (2011), 대한한방신경정신과학회
  24. 강연욱, "K-MMSE(Korean-Mini Mental State Examination)의 노인 규준 연구", 한국심리학회지:일반, 25(2), pp.1~12 (2006), 한국심리학회
  25. 구본대, "한국형 치매임상진료지침 소개", 대한의사협회지, 54(8), pp.861~875 (2011), 대한의사협회
  26. 강연욱, "혈관성 인지장애 선별검사로서 Korean-Montreal Cognitive Assessment(K-MoCA)의 신뢰도, 타당도 및 규준 연구", Korean Journal of Clinical Psychology, 28(2), pp.549~562 (2009), 한국임상심리학회[DOI]
  27. 이강수, "치매 및 경도인지장애에 대한 인지선별검사 4종의 타당도 비교", 신경정신의학, 48(2), pp.61~69 (2009), 대한신경정신의학회
  28. 한지원, "치매 선별용 간이정신상태검사(Mini-Mental State Examination for Dementia Screening;MMSE-DS)와 단축형 MMSE-DS(SMMSE-DS)의 한국 노인 정상규준 연구", 노인정신의학, 14(1), pp.27~37 (2010), 대한노인정신의학회
  29. Lee JY, "Brief screening for mild cognitive impairment in elderly outpatient clinic: Validation of the Korean version of the montreal cognitive assessment", Journal of Geriatric Psy-chiatry and Neurology, 21(2), pp.104~110 (2008)
  30. RC Petersen, "Mild cognitive impairment: clinical character-ization and outcome", Arch Neurol, 56(3), pp.303~308 (1999)
  31. B. Winblad, "Mild cognitive impairment--beyond controver-sies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment", J Intern Med, 256(3), pp.240~246 (2004)
  32. Kenneth M Langa, "The diagnosis and management of mild cognitive impairment: a clinical review", JAMA, 312(23), pp.2551~2561 (2014)
  33. Alexandre Breton, "Cognitive tests for the detection of mild cognitive impair-ment (MCI), the prodromal stage of dementia: Meta-anal-ysis of diagnostic accuracy studies", Int J Geriatr Psy-chiatry, 34(2), pp.233~242 (2019)
  34. 서은현, "치매 및 인지장애에서의 신경심리평가", 신경정신의학, 57(1), pp.2~11 (2018), 대한신경정신의학회[DOI]
  35. Min Deng, "Acupuncture for amnestic mild cognitive mpairment: a meta-analysis of rando-mised controlled trials", Acupunct Med, 34(5), pp.342~348 (2016)
  36. Zhiqun Wang, "Effect of Acupuncture in Mild Cognitive Impairment and Alzheimer Disease: A Functional MRI Study", PLoS ONE, 7(8), pp.e42730~ (2012), Public Library of Science (PLoS)[DOI]
  37. Ting-Ting Tan, "Modulatory effects of acupuncture on brain net-works in mild cognitive impairment patients", Neural Regen Res, 12(2), pp.250~258 (2017)
  38. Shangjie Chen, "Acupuncture at the Taixi (KI3)acupoint activates cerebral neurons in elderly patients with mild cognitive impairment", Neural Regen Res, 9(11), pp.1163~1168 (2014)
  39. Lin Dong, "Chinese Herbal Medicine for Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Cognitive Outcomes", Phytother Res, 30(10), pp.1592~1604 (2016)
  40. Matsuoka T, "Effect of toki-shakuyaku-san on re-gional cerebral blood flow in patients with mild cognitive impairment and Alzheimer’s disease", Evid Based Com-plement Alternat Med (2012)
  41. Kitabayashi Y, "Effect of traditional Japanese herbal medicine toki-shakuyaku-san for mild cognitive impairment: SPECT study", Psychiatry Clin Neurosci, 61(4), pp.447~448 (2007)
  42. Kim KH, "The Effect of Dangguijagyag-san on Mild Cognitive Impairment", J Altern Complement Med, 22(7), pp.509~514 (2016)
  43. Ishida K, "Effect of donepezil and kamikihito combination therapy on cognitive function in Alzheimer’s disease:Retrospective study", Tradit Kampo Med, 3(2), pp.94~99 (2016)
  44. Hong YJ, "Predictors of Clinical Progression of Subjective Me-mory Impairment in Elderly Subjects: Data from the Clini-cal Research Centers for Dementia of South Korea (CREDOS)", Dement Geriatr Cogn Disord, 40(3-4), pp.158~165 (2015)
  45. Kamini Krishnan, "Changes in Montreal Cognitive Assess-ment Scores Over Time", Journal of medicinal food, 24(6), pp.772~777 (2017)
  46. Folstein, M. F., "Mini-Mental-State: A practical method for grading the cognitive state of patients for the clinician", Journal of Psychiatric Re-search, 12(3), pp.189~198 (1975)
  47. 신경림, "경도인지장애 노인의 우울 예측 요인", 성인간호학회지, 24(2), pp.171~182 (2012), 한국성인간호학회[DOI]
  48. Kim HG, "Herbal medicines for the prevention and treatment of Alzheimer’s diseases", Current Pharm. Disign, 18(1), pp.57~75 (2012)
  49. 한설희, "알츠하이머병의 새로운 약물치료", 대한의사협회지, 52(11), pp.1059~1068 (2009), 대한의사협회

관련 논문AI추천

경도인지장애 환자의 장기간 한의약 치료 경과관찰 증례보고 2례강형원, 류영수, 손성은, 이고은, 이나현, 정문주대한한방신경정신과학회 · 동의신경정신과학회지2021 · 제32권 제3호일개 한의의료기관 내 경도인지장애의 의한협진 매뉴얼 제안강형원, 김보민, 설재욱, 손성은, 송민영, 이가원, 임정태, 조희근, 최성열대한한방신경정신과학회 · 동의신경정신과학회지2018 · 제29권 제4호치매, 경도인지장애의 한의진료 현황, 진단 및 치료에 대한 한의사의 인식도 조사 연구 - 한방신경정신과 전문의와 일반의의 차이를 중심으로 -김 환, 강형원, 김상호, 김시연, 서영경, 유동근, 이고은, 정인철대한한방신경정신과학회 · 동의신경정신과학회지2017 · 제28권 제3호경도인지장애 침치료 인지기능효과 : 체계적 문헌고찰 메타분석김원순대한예방한의학회 · 대한예방한의학회지2024 · 제28권 제2호치매 및 우울증 고위험군 116례의 한의 치료에 대한 관찰 연구장건, 김면수, 김용기, 박준영, 안영성, 이동석, 이재열, 최중길, 하현이, 황지혜한의병리학회 · 동의생리병리학회지2021 · 제35권 제3호구기지황탕 투여 후 호전된 경도인지장애 환자 1례에 대한 증례보고강석만, 김경순, 박미소, 성현주, 유대원, 유호룡, 정광렬, 채인철대한한방내과학회 · 대한한방내과학회지2021 · 제42권 제5호

이 간행물의 다른 논문 (15건)