Scopolamine으로 유발한 치매유도 쥐에 대한 저염 오징어(Todorodes pacificus) 젓갈의 인지 및 기억손상의 개선효과
Low-salt Todarodes pacificus Jeotgal improves the Learning and Memory Impairments in Scopolamine-induced Dementia Rats
2
조회
0
다운로드
6
인용
0
참고문헌
키워드
초록
We investigated the effect low salt (2 or 4% salt) concentrations jeotgal made from Todarodes pacificus on the learn- ing and memory impairments in scopolamine-induced (2 mg/kg, i.p.) dementia rats. Rats treated with oral BF-7 (200 mg/kg, p.o.) as a positive control and Todarodes pacificus jeotgal had significantly reduced scopolamine-induced memory deficits in the passive avoidance test. The Morris water maze test or treatment with 2% salt jeotgal made from Todarodes pacificus significantly ameliorated the scopolamine-induced memory deficits in the formation of long- and short-term memory. The acetylcholine content and acetylcholinesterase acitivity paralleled the results of the behavior experiment. There were no significant differences in the brain acetylcholine contents of the experimen- tal groups, while the brain acetylcholine content of the group treated with 2% salt Todarodes pacificus jeotgal was higher than that of the control group. The inhibitory effect of 2% salt jeotgal made from Todarodes pacificus on the acetylcholinesterase activity in the brain was lower than that of the control group. These trends were similar to those of the gamma-aminobutyric acid content. We suggest that Todarodes pacificus jeotgal enhances learning memory and cognitive function by regulating cholinergic enzymes.
Abstract
We investigated the effect low salt (2 or 4% salt) concentrations jeotgal made from Todarodes pacificus on the learn- ing and memory impairments in scopolamine-induced (2 mg/kg, i.p.) dementia rats. Rats treated with oral BF-7 (200 mg/kg, p.o.) as a positive control and Todarodes pacificus jeotgal had significantly reduced scopolamine-induced memory deficits in the passive avoidance test. The Morris water maze test or treatment with 2% salt jeotgal made from Todarodes pacificus significantly ameliorated the scopolamine-induced memory deficits in the formation of long- and short-term memory. The acetylcholine content and acetylcholinesterase acitivity paralleled the results of the behavior experiment. There were no significant differences in the brain acetylcholine contents of the experimen- tal groups, while the brain acetylcholine content of the group treated with 2% salt Todarodes pacificus jeotgal was higher than that of the control group. The inhibitory effect of 2% salt jeotgal made from Todarodes pacificus on the acetylcholinesterase activity in the brain was lower than that of the control group. These trends were similar to those of the gamma-aminobutyric acid content. We suggest that Todarodes pacificus jeotgal enhances learning memory and cognitive function by regulating cholinergic enzymes.
참고문헌 (42)
- Yan A, "Quantitative structure and bioactivity relationship study on human acetylcholine -esterase inhibitors", Bioorg Med Chem Lett, 22, pp.3336~3342 (2012)
- Bartus RT, "On nerodegenerative disease, models and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis", Exp Neurol, 163, pp.495~529 (2002)
- Barry JS, "Metabolism and functions of gamma-aminobutyric acid", Trends in Plant Sci, 4, pp.446~4512 (1999)
- Braida D, "An inverted U-shaped curve for heptyl physostigmine on radial maze performmance in rats: comparision with other cholinesterase inhibitors", Eur J Pharmacol, 302, pp.13~20 (1996)
- Chang JS, "Changes in γ-aminobutyric acid (GABA) and the main constituents by a treatment conditions and of anaerobically treated green tea leaves", J Korean Food Sci Technol, 24, pp.315~319 (1992)
- 최원희, "들깨 메탄올 추출물의 acetylcholinesterase 억제활성 및 세포독성 보호효과", 한국식품과학회지, 36(6), pp.1026~1031 (2004), 한국식품과학회
- Collingridge GL, "NMDA receptors-their role in long-term potentiation. Trends Neurosci 10 , 288-93. Davies P and Maloney AJ. 1976. Selective loss of central cholinergic neurons in Alzheimer's disease", Lancet, 2, pp.1403~1403 (1976)
- Dawson GR, "The behavioral effects of heptylphysostigmine: a new cholinesterase inhibitor, in tests of longterm and working memory in rodents", Pharmacol Biochem Behav, 39, pp.865~871 (1991)
- Dawson GR, "The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory", Behav Brain Res, 57, pp.143~153 (1993)
- Ebert U, "Scopolamine model of dementia: electroencephalogram findings and cognitive performance", Eur J Clin Invest, 28, pp.944~949 (1998)
- Ellman GL, "A new and rapid colorimetric determination of acetylcholinesterase activity", Biochem Pharmacol, 7, pp.88~95 (1961)
- Gerard C, "An isocratic high performance liquid chromatography method for the determination of GABA and glutamate in discrete regions of the rodent brain", J Neurosci Methods, 160, pp.223~230 (2007)
- Giacobini E, "Cholineasterase inhibitor: New role and therapeutic alternatives", Pharmacological, 50, pp.433~440 (2004)
- Hestrin S, "The reaction of acetycholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application", J Biol Chem, 180, pp.249~261 (1949)
- Paul TF, "The cholinergic hypothesis of Alzheimer's disease : a review of progress", J Neural Neurosurg Psychiatry, 66, pp.137~147 (1999)
- Giacobini E, "The cholinergic system in Alzhemer's disease", Prog Brain Res, 84, pp.321~332 (1990)
- Kasa P, "Donepezil dosedependently inhibits acetyl-cholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptive enzyme-positive structures in the human and rat brain", Neuroscience, 101, pp.89~100 (2000)
- 김도희, "천연 소재 BF-7의 어린이 장·단기 기억력 향상 효과", 한국식품영양과학회지, 39(3), pp.376~382 (2010), 한국식품영양과학회
- Kim DH, "The ameliorating effect of oroxylin A on scopolamine-induced memory impairment in mice", Neurobiol Learn Mem, 87, pp.536~546 (2007)
- Kuhl DE, "In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease", Neurology, 52, pp.691~699 (1999)
- Kwon YI, "Clinical pathology of experimantal animal", pp.180~186 (2009), Acedemia Korea
- 권영이, "청열약 추출물들의 아세틸콜린에스테라제 저해와베타아밀로이드 펩티드 응집 억제 효능", 생약학회지, 38(4), pp.308~311 (2007), 한국생약학회
- Lee BJ, "Antioxidant activity and γ-aminobutylic acid (GABA) content in sea tangle fermented by Lactobacillus brevis BJ20 isolated from traditional fermented foods", Food Chem, 122, pp.271~276 (2010)
- 이봉호, "Acetylcholinesterase 억제 및 신경세포 보호 활성을 갖는 다시마목 해조 추출물 NX42의 마우스 학습능력 향상 효과", 한국식품과학회지, 36(6), pp.974~978 (2004), 한국식품과학회
- 이형철, "한약재 물 추출물의 아세틸콜린에스테라제 활성 억제 검색", 동의생리병리학회지, 16(2), pp.2~219 (2002), 대한동의병리학회
- 이미라, "백삼과 홍삼추출물의 학습수행과 Acetylcholinesterase 억제에 미치는 효과", Journal of Ginseng Research, 32(4), pp.341~346 (2008), 고려인삼학회
- 이성현, "도토리 급여가 치매모델 마우스 뇌조직의 아세틸콜린 및 관련효소 활성에 미치는 영향", 한국식품영양과학회지, 34(5), pp.738~742 (2005), 한국식품영양과학회
- Leventhal AG, "GABA and its agonists improved visual cortical function in senescent monkeys", Science, 300, pp.812~815 (2003)
- Lowry OH, "Protein measurement with the Folin-phenol reagent", J Biol Chem, 193, pp.265~275 (1951)
- Lozenzini CA, "Role of dorsal hippocampus in acquisition, consolidation and retrieval of rat’s passive avoidance response: a tetrodotoxin functional inactivation study", Brain Res, 730, pp.32~39 (1996)
- Lu MC, "Ameliorating effect of emodin, a constitute of Polygonatum multiflorum, on cycloheximide-induced impairment of memory consolidation in rats", J Ethnopharmacol, 112, pp.552~556 (2007)
- Malcangio M, "Effect of ICV taurine on the impairment of learning, convulsions and death caused by hypoxia", Psychopharmacology, 98, pp.316~320 (1989)
- 오현경, "대두 이소플라본 섭취가 흰쥐에서 미로수행능력과 뇌 중 Acetylcholinesterase 활성에 미치는 영향", Journal of Nutrition and Health, 39(3), pp.219~224 (2006), 한국영양학회
- 박병준, "감마선 조사와 저염함량으로 제조한 된장의 미생물 및 품질특성 변화", 한국식품과학회지, 34(1), pp.79~84 (2002), 한국식품과학회
- Park CW, "Brain: Structure of Learning and Memory", pp.115~128 (1998), Seoul National University Press
- 박상신, "참외추출물이 스코폴라민 유도 기억상실 흰쥐의 인지능 회복에 미치는 효과", 생명과학회지, 19(5), pp.688~691 (2009), 한국생명과학회
- Procter AW, "Evidence of glutamatergic denervation and possible abnormal metabolism in Alzheimer's disease", J Neurochem, 50, pp.790~802 (1998)
- Rispoli V., "Choline pivaloylesters improve in rats cognitive and memory performances impaired by scopolamine treatment or lesions of nucleus basalis of Meymert", Neurosci Lett, 356, pp.199~202 (2004)
- 서태범, "저항성운동이 흰쥐 해마의 Acetylcholinesterase 활성과 공간인지능에 미치는 영향", 한국생활환경학회지, 17(5), pp.606~612 (2010), 한국생활환경학회
- Van der Zee EA, "Habituation to a test apparatus during associative learning is sufficient to enhance muscarinic acethylcholin receptorimmunoreactivity in rat suprachiasmatic nucleus", J Neurosci Res, 78, pp.508~519 (2004)
- Wesnes KA, "Cholinesterase inhibitor in the scopolamine model of dementia", Ann NY Acad Sci, 640, pp.268~271 (1991)
- Woolf NJ, "A possible role for cholinergic neurons of the basal forebrain and pontomesencephalon in consciousness", Conscious Cong, 6, pp.574~596 (1997)