Protective Effect of Lonicerae Flos Aqueous Extracts on a Pressure Overload-induced Heart Failure Model
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Objectives: Lonicerae flos (LF), a dried flower part of Lonicera japonica Thunb., has been widely used in Korean medicine as anti-inflammatory and antioxidative agent. The purpose of this study was to determine the cardioprotective effects of LF, through potential antioxidant effects, on the pressure overload (PO)-induced heart failure (HF) in C57BL/6 mice after transverse aortic constriction (TAC) surgery. Methods: Resveratrol (10 mg/kg body weight) or LF (125, 250 or 500 mg/kg body weight) was orally administered, once daily for 14 days, starting 14 days after TAC surgery. Changes in the mortality, body weights, heart weights, histopathology of the heart, and antioxidant defense systems of the heart were analyzed. Results: Marked and noticeable increases of heart weights, mortalities, and hypertrophic, focal, and lytic fibrotic histological changes in the LVs were observed, with destruction of heart antioxidant defense systems after surgery. However, HF signs, induced by TAC surgery through PO, and destruction of heart antioxidant defense systems were significantly and dose-dependently inhibited by 14 days of maintained oral treatment with LF 500, 250 or 125 mg/kg. Treatment with 250 mg/kg LF was comparable to treatment with 10 mg/kg resveratrol. Conclusions: The results in this study suggest that oral administration of LF favorably relieves PO-induced HF following TAC, through increase of heart antioxidant defense systems. The overall effects of 250 mg/kg LF were similar to those of 10 mg/kg resveratrol. More detailed mechanistic studies should be conducted in the future, with screening of the biologically active compounds in LF.
Abstract
Objectives: Lonicerae flos (LF), a dried flower part of Lonicera japonica Thunb., has been widely used in Korean medicine as anti-inflammatory and antioxidative agent. The purpose of this study was to determine the cardioprotective effects of LF, through potential antioxidant effects, on the pressure overload (PO)-induced heart failure (HF) in C57BL/6 mice after transverse aortic constriction (TAC) surgery. Methods: Resveratrol (10 mg/kg body weight) or LF (125, 250 or 500 mg/kg body weight) was orally administered, once daily for 14 days, starting 14 days after TAC surgery. Changes in the mortality, body weights, heart weights, histopathology of the heart, and antioxidant defense systems of the heart were analyzed. Results: Marked and noticeable increases of heart weights, mortalities, and hypertrophic, focal, and lytic fibrotic histological changes in the LVs were observed, with destruction of heart antioxidant defense systems after surgery. However, HF signs, induced by TAC surgery through PO, and destruction of heart antioxidant defense systems were significantly and dose-dependently inhibited by 14 days of maintained oral treatment with LF 500, 250 or 125 mg/kg. Treatment with 250 mg/kg LF was comparable to treatment with 10 mg/kg resveratrol. Conclusions: The results in this study suggest that oral administration of LF favorably relieves PO-induced HF following TAC, through increase of heart antioxidant defense systems. The overall effects of 250 mg/kg LF were similar to those of 10 mg/kg resveratrol. More detailed mechanistic studies should be conducted in the future, with screening of the biologically active compounds in LF.
참고문헌 (30)
- Braunwald E, "The war against heart failure:the Lancet lecture", Lancet, 385(9970), pp.812~824 (2015)
- Roger VL, "Heart disease and stroke statistics 2012 update: a report from the American Heart Association", Circulation, 125(1), pp.e2~e220 (2012)
- Ponikowski P, "2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC", Eur Heart J, 37(27), pp.2129~2200 (2016)
- Munzel T, "Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications", European Heart Journal, 36(38), pp.2555~2564 (2015)[DOI]
- Hunt SA, "2009 Focused update incorporated in to the ACC", AHA 2005Guidelines for the Diagnosis and Management of Heart Failure in Adults A report of the American College of Cardiology Foundation, J Am Coll Cardiol, pp.2009, 53(15)[DOI]
- Ezekowitz JA, "Trends in heart failure care: has the incident diagnosis of heart failure shifted from the hospital to the emergency department and outpatient clinics", Eur J Heart Fail, 13(2), pp.142~147 (2011)[DOI]
- Ku SK, "Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity", World J Gastroenterol, 15(38), pp.4799~4805 (2009)
- 구세광, "금은화가 6-n-propyl-2-thiouracil (PTU) 로 유발된 흰쥐의 갑상샘 기능저하증에 미치는 영향", 동의생리병리학회지, 24(4), pp.630~637 (2010), 한의병리학회
- Tian J, "Characterization and anti-allergic effect of a polysaccharide from the flower buds of Lonicera japonica", Carbohydrate Polymers, 90(4), pp.1642~1647 (2012)
- Elliott PJ, "Sirtuins: novel targets for metabolic disease", Curr Opin Investig Drugs, 9(4), pp.371~378 (2008)
- Dolinsky VW, "Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1", Circulation, 119(12), pp.1643~1652 (2009)
- Rimbaud S, "Resveratrol Improves Survival, Hemodynamics and Energetics in a Rat Model of Hypertension Leading to Heart Failure", PloS one, 6(10), pp.e26391~ (2011)
- Lan W, "Characterization of antioxidant activity of extracts from Flos Lonicerae", Drug Dev Ind Pharm, 33(8), pp.841~847 (2007)
- Gupta PK, "Protective effect of resveratrol against pressure overloadinduced heart failure", Food Sci Nutr, 2(3), pp.218~229 (2014)
- Qi J, "Apocynum tablet protects against cardiac hypertrophy via inhibiting AKT and ERK1", 2phosphorylation after pressure overload, 2014, pp.2014, 769515~
- Songstad NT, "Effect of transverse aortic constriction on cardiac structure, function and gene expression in pregnant rats", PLoS One, 9(2), pp.e89559~ (2014)
- van Empel VP, "EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant", J Am Coll Cardiol, 48(4), pp.824~832 (2006)
- Bento DB, "Oxidative stress in mice treated with antileishmanial meglumine antimoniate", Res Vet Sci, 95(3), pp.1134~1141 (2013)
- Fox JG, "Laboratory animal medicine" (1984), Academic Press Inc
- Tajima Y, "Biological reference data book on experimental animals" (1989), Soft Science Inc
- Frey N, "Cardiac hypertrophy: the good, the bad, and the ugly", Annu Rev Physiol, 65, pp.45~79 (2003)
- Gersh BJ, "2011 ACCF", AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: a report of the American College of Cardiology Foundation, J Am Coll Cardiol, pp.2011, 58(25)[DOI]
- Juric D, "Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol", Am J Physiol Heart Circ Physiol, 292(5), pp.H2138~H2143 (2007)
- Wojciechowski P, "Resveratrol arrests and regresses the development of pressure overloadbut not volume overload-induced cardiac hypertrophy in rats", J Nutr, 140(5), pp.962~968 (2010)
- Yu S, "MicroRNA expression and function in cardiac ischemic injury", J Cardiovasc Transl Res, 3(3), pp.241~245 (2010)
- Dai DF, "Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress", Cardiovasc Res, 93(1), pp.79~88 (2012)
- Koga K, "Macrophage migration inhibitory factor antagonizes pressure overload-induced cardiac hypertrophy", Am J Physiol Heart Circ Physiol, 304(2), pp.H282~H293 (2013)
- Odabasoglu F, "Gastroprotective and antioxidant effects of usnic acid on indomethacininduced gastric ulcer in rats", J Ethnopharmacol, 103(1), pp.59~65 (2006)
- Cheeseman KH, "An introduction to free radical biochemistry", Br Med Bull, 49(3), pp.481~493 (1993)
- Zhou Y, "Pharmacokinetics and tissue distribution study of chlorogenic Acid from lonicerae japonicae flos following oral administrations in rats", Evid Based Complement Alternat Med, 2014, pp.979414~ (2014)