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정신분열병과 Glutathione S-transferase P1 유전자 다형성

Schizophrenia and Glutathione S-transferase P Gene Polymorphism

김정진|이수정|이영민|이철|이창욱|배치운|백인호|유혜숙|양대현
대한신경정신의학회 (Korean Neuropsychiatric Association)|2004.01|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제43권 제1호|pp. 23-28

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참고문헌

키워드

연합연구 · 정신분열병Association study · Glutathione S-transferase P gene (GSTP1) polymorphism · Schizophrenia.
주제분류정신과학

초록

Abstract

Objectives：This study is aimed to test the association between the coding sequence functional polymorphism (I105 V) of glutathione S-transferase P gene (GSTP1) and schizophrenia. Methods：Two hundred fourteen (214) patients with schizophrenia according to the DSM-IV criteria and one hundred ten (110) healthy controls were enrolled in this study. Patients and controls were biologically unrelated age and sex- matched native Koreans. Genotyping for the GSTP1 polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Results：Genotype and allele distributions of the GSTP1 polymorphism in patients with schizophrenia were not significantly different from those of the controls. Comparisons of clinical variables also were not different according to genotype and allele distribution. Conclusion：The present study suggests that the GSTP1 polymorphism may not confer susceptibility to development of schizophrenia, at least in the Korean population. (J Korean Neuropsychiatr Assoc 2004;43(1):23-28)

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관련 논문AI추천

정신분열병과 Glutathione S-Transferase M1 유전자 다형성이철, 김연주, 김정진, 김태석, 배치운, 백인호, 이수정, 이창욱, 전태연, 조자현대한신경정신의학회 · 신경정신의학2004 · 제43권 제5호정신분열병 환자에서 Apolipoprotein E 유전자 다형성류철형, 임채기, 최영숙대한신경정신의학회 · 신경정신의학2001 · 제40권 제3호정신분열병과 heat shock protein 70 유전자 다형성과의 관련이철, 권오주, 김정진, 백인호, 이경욱, 이수정, 이창욱, 한진희대한신경정신의학회 · 신경정신의학2002 · 제41권 제5호기능성 Catechol-O-Methyltransferase 유전자 다형성과 한국인 정신분열병의 관련성강대희, 김형섭, 박임순, 박태원, 배수영, 윤경식, 최인미, 홍영준대한신경정신의학회 · 신경정신의학2001 · 제40권 제4호정신분열병에 대한 분자유전학적 연구의 현황과 앞으로의 방향이병대대한생물치료정신의학회 · 생물치료정신의학2005 · 제11권 제2호Brain-derived Neurotrophic Factor Val66Met 다형성과 정신분열병의 연합 연구김대진, 김용구, 이화영대한생물정신의학회 · 생물정신의학2006 · 제13권 제4호

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