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정신분열병과 Glutathione S-Transferase M1 유전자 다형성

Glutathione S-Transferase M1 Polymorphism and Schizophrenia

김정진|이수정|전태연|김연주|이철|김태석|이창욱|배치운|백인호|조자현
대한신경정신의학회 (Korean Neuropsychiatric Association)|2004.09|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제43권 제5호|pp. 519-523

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참고문헌

키워드

GSTM1 유전자다형성 · 정신분열병 · 지연성 운동장애.GSTM1 gene polymorphism · Schizophrenia · Tardive dyskinesia.
주제분류정신과학

초록

Abstract

Objectives：This study aimed to test the possible association between Glutathione S-Transferase M1 gene (GSTM1) variants and schizophrenia. Methods：One hundred and eleven inpatients with schizophrenia and 130 healthy controls were recruited. Genotyping was performed by polymerase chain reaction-based method. Results：The GSTM1 null genotype was significantly more frequent in patients with schizophrenia than in controls (p=0.014, odd ratio=1.93, 95% confidence interval=1.115-3.351), while GSTM1 genotype variants were not associated with either tardive dyskinesia (TD) or total Abnormal Involuntary Movement Scale (AIMS) scores. Conclusion：The present study suggests that the GSTM1 polymorphism may confer susceptibility to the development of schizophrenia but not to TD, at least in Korean population. (J Korean Neuropsychiatr Assoc 2004;43(5):519-523)

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