다빈도 협진 질환의 후향적 진료기록 분석 연구 : 예비연구
Retrospective Medical Record Analysis on Frequent Disease of Collaboration: A Pilot Study
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Objectives: This pilot study aimed to confirm the possibility of applying our design to the main study, a retrospective medical record analysis of the diseases which have most frequently been treated with collaborations of Korean and Western medicine, and to identify what corrections and statistical models are needed to conduct the main study. Methods: Data were collected from a case report form developed for patients who received treatment in the medical institutions. Appropriate statistical techniques, like Propensity Score (PS) and Generalized Estimation Equation (GEE) models, were used to compare the indicators of collaboration and non-collaboration groups for patients in comparable diseases. Results: Using PS matching for each M and S disease group, the indicators were compared by balancing the collaboration and non-collaboration group, and the GEE models compared indicators between groups in each disease over follow-up. Through this process we identified two limitations, insufficient samples and a large deviation of the follow-up period. Conclusion: This pilot study confirmed that the study design and case report form are applicable. The main study will be conducted by collecting sufficient samples and reflecting deviation of follow-up period.
Abstract
Objectives: This pilot study aimed to confirm the possibility of applying our design to the main study, a retrospective medical record analysis of the diseases which have most frequently been treated with collaborations of Korean and Western medicine, and to identify what corrections and statistical models are needed to conduct the main study. Methods: Data were collected from a case report form developed for patients who received treatment in the medical institutions. Appropriate statistical techniques, like Propensity Score (PS) and Generalized Estimation Equation (GEE) models, were used to compare the indicators of collaboration and non-collaboration groups for patients in comparable diseases. Results: Using PS matching for each M and S disease group, the indicators were compared by balancing the collaboration and non-collaboration group, and the GEE models compared indicators between groups in each disease over follow-up. Through this process we identified two limitations, insufficient samples and a large deviation of the follow-up period. Conclusion: This pilot study confirmed that the study design and case report form are applicable. The main study will be conducted by collecting sufficient samples and reflecting deviation of follow-up period.
참고문헌 (5)
- "Implementation of the third-stage pilot project for Korean and Western Medicine Collaboration" (2019)[URL]
- 전은희, "대상질환군으로 본 의⋅한 협진연구 경향 분석", 대한한방내과학회지, 41(4), pp.658~667 (2020), 대한한방내과학회[DOI]
- 곽상규, "후향적연구의 집단 간 동등성확보를 통한 임상자료분석", 한국데이터정보과학회지, 26(6), pp.1317~1325 (2015), 한국데이터정보과학회[DOI]
- Rubin DB, "Using Propensity Scores to Help Design Observational Studies: Application to the Tobacco Litigation", Health Services and Outcomes Research Methodology, 2(3), pp.169~188 (2001)
- Stuart EA, "Matching methods for causal inference:A review and a look forward", Stat Sci, 25(1), pp.1~21 (2010)