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3T3-L1 지방세포 내의 Leptin에 미치는 Polymannuronates의 영향

The Effects ofPolymannuronates on Leptin in 3T3-L1 Adipocytes

남택정|김인혜
한국수산과학회 (The Korean Society of Fisheries and Aquatic Science)|2004.10|한국수산과학회지 (Korean Journal of Fisheries and Aquatic Sciences)|제37권 제5호|pp. 372-379

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참고문헌

주제분류수산학

초록

Abstract

This study evaluated polymanuronates on the differentiation of 3T3-L1 adipocytes. Polymannuronates increased glucose utilization and reduced the accumulation of triglycerides in the cells. The differentiation showed the same results as Oil red O staining. Also, the polymannuronates inhibited GPDH activity as a result of the restrained adipogenesis promotion process in 3T3-L1 adipocytes. The addition of the differentiation promotion factor to 3T3-L1 promoted the differentiation of adipocytes and increased the expression of the leptin level. However the addition of polymannuronates inhibited differentiation of adipocytes and the leptin secretion level in cells by checking the leptin protein level in the culture media. As well as this, it also inhibited the transcriptional mechanism and leptin mRNA expression. These results suggest that the addition of polymannuronates improves the physiological function of 3T3-L1 cells by reducing the accumulation of triglyceride and GPDH activity, and the repressing expression of leptin at a molecular level.

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관련 논문AI추천

Polymannuronate가 흰쥐의 혈청과 간장조직중의 Leptin에 미치는 영향권미진, 권지영, 김인혜, 남택정, 이동수한국수산과학회 · 한국수산과학회지2003 · 제36권 제6호포화지방산과 불포화지방산이 배양 지방세포의 비만유전자와 지방산합성효소유전자 발현에 미치는 영향김용운, 김종연, 김희선, 박소영, 지정규영남대학교 의과대학 · Journal of Yeungnam Medical Science2007 · 제24권 제2호3T3-L1 cell에서 방풍통성산의 지방세포 분화 억제 효과 연구김덕곤, 이경태, 이진용, 차민경대한한방소아과학회 · 대한한방소아과학회지2006 · 제20권 제2호율피 추출물이 3T3-L1 지방전구세포 분화에 미치는 영향이선구한의병리학회 · 동의생리병리학회지2010 · 제24권 제2호Anti-adipogenic effect of mulberry leaf ethanol extract in 3T3-L1 adipocytes박나영, 양수진, 임윤숙한국영양학회 · Nutrition Research and Practice2014 · 제8권 제6호3T3-L1 세포 모델에서 Adipogenesis 조절을 통한 녹색입 홍합 추출물의 항비만 활성김교남, 김시경, 손명수, 이승철한국피부과학연구원 · 아시안뷰티화장품학술지2013 · 제11권 제6호

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