牛蒡子의 아토피 피부염에 대한 효과
Effects of Arctium lappa Linne on the DNFB- induced allergic dermatitis
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Objectives : Atopic dermatitis is a chronic inflammatory skin disease which is characterized by severe pruritis, erythema, edema, effusion and scabs. The aim of this study was to understand effects of Arctium lappa Linne, which is well known for its efficacy for various skin diseases, on atopic dermatitis Methods : We conducted this experiment using the DNFB-induced NC/Nga mice. After two weeks of applying DNFB to NC/Nga mice, severe symptoms of atopic dermatitis occurred. We divided the mice into three different groups: a control group which was given no treatment at all, a group treated with dexamethasone (1mg/kg), and another group treated with Arctium lappa Linne (300mg/kg). After one week of treatment, results were recorded according to their improvement on skin, itching behavior, IL-4, and INF-γ measurement, which is a significant criterion for diagnosing atopic dermatitis. Results : Itching behavior showed significant improvement in the Arctium lappa Linne group. However Arctium lappa Linne failed to reduce IL-4 and INF-γ count. Also there was no satisfying improvement on AD-like skin lesions on the rostral back of the NC/Nga mice treated with Arctium lappa Linne. Conclusions : Arctium lappa Linne showed improvement in itching behavior in NC/Nga mice induced by DNFB. Arctium lappa Linne showed neither significant improvement on skin lesions nor in IL-4 and INF-γ measurement.
Abstract
Objectives : Atopic dermatitis is a chronic inflammatory skin disease which is characterized by severe pruritis, erythema, edema, effusion and scabs. The aim of this study was to understand effects of Arctium lappa Linne, which is well known for its efficacy for various skin diseases, on atopic dermatitis Methods : We conducted this experiment using the DNFB-induced NC/Nga mice. After two weeks of applying DNFB to NC/Nga mice, severe symptoms of atopic dermatitis occurred. We divided the mice into three different groups: a control group which was given no treatment at all, a group treated with dexamethasone (1mg/kg), and another group treated with Arctium lappa Linne (300mg/kg). After one week of treatment, results were recorded according to their improvement on skin, itching behavior, IL-4, and INF-γ measurement, which is a significant criterion for diagnosing atopic dermatitis. Results : Itching behavior showed significant improvement in the Arctium lappa Linne group. However Arctium lappa Linne failed to reduce IL-4 and INF-γ count. Also there was no satisfying improvement on AD-like skin lesions on the rostral back of the NC/Nga mice treated with Arctium lappa Linne. Conclusions : Arctium lappa Linne showed improvement in itching behavior in NC/Nga mice induced by DNFB. Arctium lappa Linne showed neither significant improvement on skin lesions nor in IL-4 and INF-γ measurement.
참고문헌 (27)
- 이선영, "아토피성 피부염의 진단과 치료", 가정의학회지, 25(11), pp.106~111 (2004)
- 김정희, "아토피피부염의 최신지견", 대한소아알레르기및호흡기학회지, 14(1), pp.12~23 (2004), 대한 소아알레르기 호흡기학회
- 공남미, "아토피피부염의 양한방적 고찰", 대한외관과학회지, 12, pp.241~253 (1999)
- 江育仁, "實用中醫兒科學", pp.760~762 (1995), 상해과학기술출판사
- 전국한의과대학 공동교재편집위원회, "본초학", pp.181~182 (2004), 영림사
- 유한전, "우방자의 항알러지 효과에 대한 연구", 대한본초학회지, 16(1), pp.111~128 (2001)
- 이승혜, "마우스에서 2,4-Dinitrochlorobenzene을 이용한 아토피성 피부염 발현 관련면역지표치 분석", 한국독성학회지, 22(4), pp.357~364 (2006), 한국독성학회
- 대한 소아알레르기 호흡기학회, "소아 알레르기 호흡기학", pp.145~173 (2005), 군자 출판사
- 宋書功, "金櫃要略廣州敎典", pp.221~225 (1994), 人民衛生出版社
- 巢元方, "巢氏諸病源候論", pp.251~253 (1992), 大成文化社
- 陳實功, "外科正宗", pp.30~34 (1989), 上海科學技術出版社
- 祁坤, "外科大成", pp.198~ (1987), 文光圖書有限公社
- 吳謙, "醫宗金鑑(下)", pp.443~ (1982), 人民衛生出版社
- 노병윤, "피부과의 한방치료", pp.68~71 (1991), 일중사
- 내기, "사문전. 중한명의별록", pp.91~ (1997), 국제서국
- 국가중의약관리국, "중화본초", pp.653~655 (1999), 상해과학기술출판사
- 남지영, "牛蒡子가 항알러지 염증반응에 미치는 영향", 대한한방소아과학회지, 20(1), pp.241~255 (2006), 대한한방소아과학회
- 조윤희, "Analysis of Linoleic Acid on the Extraction Method of arcti Fructus", 대한본초학회지, 17(2), pp.2~17 (2002), 대한본초학회
- 김성훈, "當歸飮子加減方과 外治方 병용이 NC", Nga 아토피 생쥐에 미치는 영향, 2005, pp.18(1), 27~49[DOI]
- 이경기, "淸熱潤膚湯이 DNFB로 유발된 알레르기 피부염에 미치는 효과", 대한한방내과학회지, 29(3), pp.730~741 (2008), 대한한방내과학회
- 홍철희, "溫淸飮과 三黃洗劑加味方 병용이 NC", Nga 아토피 생쥐에 미치는 영향, 2007, pp.21(3), 679~687[DOI]
- 송성필, "當歸飮子와 三黃洗劑加味方 병용이 NC", Nga 아토피 생쥐에 미치는 영향, 2007, pp.21(5), 1210~1218[DOI]
- 백윤하, "DNCB로 자극한 NC", Nga 생쥐에서 단삼의 아토피 억제 효과, 경원대학교, 2006
- 김의철, "화피의 NC", Nga mice 에서의 아토피 피부염 양상의 피부병변 발전에 대한 억제효과, 2006, pp.(1), 1~11
- Naoki Inagaki, "Inhibition of scratching behavior associated with allergic dermatitis in mice by tacrolimus, but not by dexamethasone", European Journal of Pharmacology, 546, pp.189~196 (2006)
- Taniguchi Y, "Oral administration of royal jelly inhibits the development of atopy dermatitis- like skin lesions in NC", Nga mice, 2003, pp.3(9), 1313~1324
- Thepen T, "Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial Th2 response to a Th2 response in situ: An immu-nocytochemical study", J.Allergy Clin. Immunol, 97, pp.828~837 (1996)