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Biological activity of peptides purified from fish skin hydrolysates

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초록

Fish skin waste accounts for part of the solid waste generated from seafood processing. Utilization of fish skin by bioconversion into high-grade products would potentially reduce pollution and economic cost associated with treating fish processing waste. Fish skin is an abundant supply of gelatin and collagen which can be hydrolyzed to produce bioactive peptides of 2–20 amino acid sequences. Bioactivity of peptides purified from fish skin includes a range of activities such as antihypertensive, anti-oxidative, antimicrobial, neuroprotection, antihyperglycemic, and anti-aging. Fish skin acts as a physical barrier and chemical barrier through antimicrobial peptide innate immune action and other functional peptides. Small peptides have been demonstrated to possess biological activities which are based on their amino acid composition and sequence. Fish skin-derived peptides contain a high content of hydrophobic amino acids which contribute to the antioxidant and angiotensin-converting enzyme inhibitory activity. The peptide-specific composition and sequence discussed in this review can be potentially utilized in the development of pharmaceutical and nutraceutical products.

Abstract

Fish skin waste accounts for part of the solid waste generated from seafood processing. Utilization of fish skin by bioconversion into high-grade products would potentially reduce pollution and economic cost associated with treating fish processing waste. Fish skin is an abundant supply of gelatin and collagen which can be hydrolyzed to produce bioactive peptides of 2–20 amino acid sequences. Bioactivity of peptides purified from fish skin includes a range of activities such as antihypertensive, anti-oxidative, antimicrobial, neuroprotection, antihyperglycemic, and anti-aging. Fish skin acts as a physical barrier and chemical barrier through antimicrobial peptide innate immune action and other functional peptides. Small peptides have been demonstrated to possess biological activities which are based on their amino acid composition and sequence. Fish skin-derived peptides contain a high content of hydrophobic amino acids which contribute to the antioxidant and angiotensin-converting enzyme inhibitory activity. The peptide-specific composition and sequence discussed in this review can be potentially utilized in the development of pharmaceutical and nutraceutical products.

참고문헌 (107)

  1. Abdelhedi O, "Collagenous proteins from black-barred halfbeak skin as a source of gelatin and bioactive peptides", Food Hydrocoll, 70, pp.123~133 (2017)
  2. Adessi C, "Converting a peptide into a drug : strategies to improve stability and bioavailability", Curr Med Chem, 16, pp.963~978 (2002)
  3. Bergsson G, "Isolation and identification of antimicrobial components from the epidermal mucus of Atlantic cod(Gadus morhua)", FEBS J, 19, pp.4960~4969 (2005)
  4. Bernardini RD, "Antioxidant and antimicrobial peptidic hydrolysates from muscle protein sources and by-products", Food Chem, 4, pp.1296~1307 (2011)
  5. Bueno-Solano C, "Chemical and biological characteristics of protein hydrolysates from fermented shrimp by-products", Food Chem, 3, pp.671~675 (2009)
  6. Hee-GukByun, "Structure and Activity of Angiotensin I Converting EnzymeInhibitory Peptides Derived from Alaskan Pollack Skin", BMB reports, 35(2), pp.239~243 (2002), 한국생화학분자생물학회
  7. Cai L, "Purification and characterization of three antioxidant peptides from protein hydrolysate of grass carp(Ctenopharyngodon idella)skin", J Funct Foods, 16, pp.234~242 (2015)
  8. Camargo ACM, "Bradykinin-potentiating peptides : beyond captopril", Toxicon, 4, pp.516~523 (2012)
  9. Campoverde C, "Ontogeny and modulation after PAMPs stimulation of β-defensin, hepcidin, and piscidin antimicrobial peptides in meagre(Argyrosomus regius)", Fish Shellfish Immunol, 69, pp.200~210 (2017)
  10. Carrasco-Castilla J, "Antioxidant and metal chelating activities of peptide fractions from phaseolin and bean protein hydrolysates", Food Chem, 135, pp.1789~1795 (2012)
  11. Chalamaiah M, "Fish protein hydrolysates : proximate composition, amino acid composition, antioxidant activities and applications : a review", Food Chem, 135, pp.3020~3038 (2012)
  12. Chaud MV, "Iron derivatives from casein hydrolysates as a potential source in the treatment of iron deficiency", J Agric Food Chem, 50, pp.871~877 (2002)
  13. Chen Q, "Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro", Nutrition, 25, pp.340~349 (2009)
  14. Chen T, "Protective effect of gelatin peptides from pacific cod skin against photoaging by inhibiting the expression of MMPs via MAPK signaling pathway", J Photochem Photobiol B Biol, 165, pp.34~41 (2016)
  15. Cheung HS, "Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence", J Biol Chem, 255, pp.401~405 (1980)
  16. Cheung IWY, "Enzymatic production of protein hydrolysates from steelhead(Oncorhynchus mykiss)skin gelatin as inhibitors of dipeptidylpeptidase IV and angiotensin-I converting enzyme", J Funct Foods, 28, pp.254~264 (2017)
  17. Chi CF, "Purification and identification of three novel antioxidant peptides from protein hydrolysate of bluefin leatherjacket(Navodon septentrionalis)skin", Food Res Int, 73, pp.124~129 (2015)
  18. 최동영, "Natural products from marine organisms with neuroprotective activity in the experimental models of Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke: their molecular targets and action mechanisms", Archives of Pharmacal Research, 38(2), pp.139~170 (2015), 대한약학회
  19. Choonpicharn S, "Antioxidant and antihypertensive activity of gelatin hydrolysate from Nile tilapia skin", J Food Sci Technol, 52, pp.3134~3313 (2015)
  20. Cole AM, "Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder", J Biol Chem, 272, pp.12008~12013 (1997)
  21. Conlon JM, "Purification of naturally occurring peptides by reversed-phase HPLC", Nat Protoc England, 2(1), pp.191~197 (2007)
  22. Cushman DW, "Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung", Biochem Pharmacol, 20, pp.1637~1648 (1971)
  23. Daiber A, "Organic nitrate therapy, nitrate tolerance, and nitrateinduced endothelial dysfunction : emphasis on redox biology and oxidative stress", Antioxid Redox Signal, 23, pp.899~942 (2015)
  24. Dessy C, "Pathophysiological roles of nitric oxide : in the heart and the coronary vasculature", Curr Med Chem Anti-inflamm Anti-Allergy Agents, 3, pp.207~216 (2004)
  25. Dezsi L, "Fibrinolytic actions of ACE inhibitors : a significant plus beyond antihypertensive therapeutic effects", Cardiovasc Res, 47, pp.642~644 (2000)
  26. Elias RJ, "Antioxidant activity of proteins and peptides", Crit Rev Food Sci Nutr, 48, pp.430~441 (2008)
  27. Fahmi A, "Production of angiotensin I converting enzyme inhibitory peptides from sea bream scales", Process Biochem, 39, pp.1195~1200 (2004)
  28. Fang B, "Conversion of turbot skin wastes into valuable functional substances with an eco-friendly fermentation technology", J Clean Prod, 156, pp.367~377 (2017)
  29. Garner B, "Oxidation of high density lipoproteins - I. Formation of methionine sulfoxide in apolipoproteins AI and AII is an early event that accompanies lipid peroxidation and can be enhanced by alpha-tocopherol", J Biol Chem, 273, pp.6080~6087 (1998)
  30. Giri A, "Antioxidative properties of aqueous and aroma extracts of squid miso prepared with Aspergillus oryzaeinoculated koji", Food Res Int, 44, pp.317~325 (2011)
  31. Guang C, "Plant food-derived angiotensin I converting enzyme inhibitory peptides", J Agric Food Chem, 57, pp.b5113~b5120 (2009)
  32. Haass C, "Soluble protein oligomers in neurodegeneration : lessons from the Alzheimer’s amyloid β-peptide", Nat Rev Mol Cell Biol, 8, pp.101~112 (2007)
  33. Halim NRA, "Functional and bioactive properties of fish protein hydolysates and peptides : a comprehensive review", Trends Food Sci Technol, 51, pp.24~33 (2016)
  34. Hara H, "Portal absorption of small peptides in rats under unrestrained conditions", J Nutr, 114, pp.1122~1129 (1984)
  35. Hartmann R, "Food-derived peptides with biological activity : from research to food applications", Curr Opin Biotechnol, 18, pp.163~169 (2007)
  36. Huang CY, "Evaluation of iron-binding activity of collagen peptides prepared from the scales of four cultivated fishes in Taiwan", J Food Drug Anal, 23, pp.671~678 (2015)
  37. Huang SL, "Dipeptidyl-peptidase IV inhibitory activity of peptides derived from tuna cooking juice hydrolysates", Peptides, 35, pp.114~121 (2012)
  38. Iwaniak A, "Food-originating ACE inhibitors, including antihypertensive peptides, as preventive food components in blood pressure reduction", Compr Rev Food Sci Food Saf, 13, pp.114~134 (2014)
  39. Jongjareonrak A, "Isolation and characterisation of acid and pepsin-solubilised collagens from the skin of Brownstripe red snapper(Lutjanus vitta)", Food Chem, 93, pp.475~484 (2005)
  40. Jridi M, "Chemical and biophysical properties of gelatins extracted from alkali-pretreated skin of cuttlefish(Sepia officinalis)using pepsin", Food Res Int, 54, pp.1680~1687 (2013)
  41. Katzenback B, "Antimicrobial peptides as mediators of innate immunity in teleosts", Biology(Basel), 4, pp.607~639 (2015)
  42. Kaur C, "Antioxidants in fruits and vegetables–the millennium’s health", Int J Food Sci Technol, 36, pp.703~725 (2001)
  43. Kearney PM, "Global burden of hypertension : analysis of worldwide data", Lancet, 365, pp.217~223 (2005)
  44. Kembhavi AA, "Salt-tolerant and thermostable alkaline protease from Bacillus subtilis NCIM No. 64", Appl Biochem Biotechnol, 38, pp.83~92 (1993)
  45. Kim DU, "Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity, and wrinkling in human skin : a randomized, double-blind, placebo-controlled study", Nutrients, 10, pp.826~ (2018)
  46. Kim SK, "Bioactive compounds from marine processing byproducts-a review", Food Res Int, 39, pp.383~393 (2006)
  47. 김세권, "Prospective of the Cosmeceuticals Derived from Marine Organisms", Biotechnology and Bioprocess Engineering, 13(5), pp.511~523 (2008), 한국생물공학회
  48. Kim SK, "Development and biological activities of marine-derived bioactive peptides : a review", J Funct Foods, 2, pp.1~9 (2010)
  49. Kleekayai T, "Extraction of antioxidant and ACE inhibitory peptides from Thai traditional fermented shrimp pastes", Food Chem, 176, pp.441~447 (2015)
  50. Korhonen H, "Food-derived bioactive peptides--opportunities for designing future foods", Curr Pharm Des, 9, pp.1297~1308 (2003)
  51. Lacroix IME, "Evaluation of the potential of dietary proteins as precursors of dipeptidyl peptidase(DPP)-IV inhibitors by an in silico approach", J Funct Foods, 4, pp.403~422 (2012)
  52. Lacroix IME, "Isolation and characterization of peptides with dipeptidyl peptidase-IV inhibitory activity from pepsin-treated bovine whey proteins", Peptides, 54, pp.39~48 (2014)
  53. Lassoued I, "Characteristics and functional properties of gelatin from thornback ray skin obtained by pepsinaided process in comparison with commercial halal bovine gelatin", Food Hydrocoll, 41, pp.309~318 (2014)
  54. Lassoued I, "Characterization and comparative assessment of antioxidant and ACE inhibitory activities of thornback ray gelatin hydrolysates", J Funct Foods, 13, pp.225~238 (2015)
  55. Lau CC, "Novel angiotensin I-converting enzyme inhibitory peptides derived from edible mushroom Agaricus bisporus (J.E. Lange) Imbach identified by LC-MS", MS, 2014, pp.148, 396~401
  56. Lee EJ, "Fish collagen peptide inhibits the adipogenic differentiation of preadipocytes and ameliorates obesity in high fat diet-fed mice", Int J Biol Macromol, 104, pp.281~286 (2017)
  57. Lee JK, "Effect of angiotensin I converting enzyme inhibitory peptide purified from skate skin hydrolysate", Food Chem, 125, pp.495~499 (2011)
  58. Lee JK, "Antihypertensive effect of novel angiotensin I converting enzyme inhibitory peptide from chum salmon(Oncorhynchus keta)skin in spontaneously hypertensive rats", J Funct Foods, 7, pp.381~389 (2014)
  59. Lee JK, "Characterization of β-secretase inhibitory peptide purified from skate skin protein hydrolysate", Eur Food Res Technol, 240, pp.129~136 (2015)
  60. Lee SH, "Purification of an iron-binding nona-peptide from hydrolysates of porcine blood plasma protein", Process Biochem, 44, pp.378~381 (2009)
  61. Lee SH, "A novel angiotensin I converting enzyme inhibitory peptide from tuna frame protein hydrolysate and its antihypertensive effect in spontaneously hypertensive rats", Food Chem, 118, pp.96~102 (2010)
  62. Lu J, "Identification of MMP-1 inhibitory peptides from cod skin gelatin hydrolysates and the inhibition mechanism by MAPK signaling pathway", J Funct Foods, 33, pp.251~260 (2017)
  63. Ma Q, "Protective effects of LSGYGP from fish skin gelatin hydrolysates on UVB-induced MEFs by regulation of oxidative stress and matrix metalloproteinase activity", Nutrients, 10, pp.420~ (2018)
  64. Mahboob S, "Isolation and characterization of collagen from fish waste materialskin, scales and fins of Catla catla and Cirrhinus mrigala", J Food Sci Technol, 52, pp.4296~4305 (2014)
  65. Majumdar RK, "Chemical and microbial properties of shidal, a traditional fermented fish of Northeast India", J Food Sci Technol, 53, pp.401~410 (2016)
  66. Mendis E, "Investigation of jumbo squid(Dosidicus gigas)skin gelatin peptides for their in vitro antioxidant effects", Life Sci, 77, pp.2166~2178 (2005)
  67. Mendis E, "Antioxidant properties of a radical-scavenging peptide purified from enzymatically prepared fish skin gelatin hydrolysate", J Agric Food Chem, 53, pp.581~587 (2005)
  68. Nagarajan M, "Characteristics and functional properties of gelatin from splendid squid(Loligo formosana)skin as affected by extraction temperatures", Food Hydrocoll, 29, pp.389~397 (2012)
  69. Nakajima H, "Glyceraldehyde-3-phosphate dehydrogenase(GAPDH)aggregation causes mitochondrial dysfunction during oxidative stress-induced cell death", J Biol Chem, 292, pp.4727~4742 (2017)
  70. Ngo DH, "Protective effects of peptides from skate(Okamejei kenojei)skin gelatin against endothelial dysfunction", J Funct Foods, 10, pp.243~251 (2014)
  71. Ngo DH, "Angiotensin-I converting enzyme inhibitory peptides from antihypertensive skate(Okamejei kenojei)skin gelatin hydrolysate in spontaneously hypertensive rats", Food Chem, 174, pp.37~43 (2014)
  72. Ngo DH, "In vitro antioxidant activity of a peptide isolated from Nile tilapia(Oreochromis niloticus)scale gelatin in free radicalmediated oxidative systems", J Funct Foods, 2, pp.107~117 (2010)
  73. Ngo DH, "Free radical scavenging and angiotensin-I converting enzyme inhibitory peptides from Pacific cod(Gadus macrocephalus)skin gelatin", Int J Biol Macromol, 49, pp.1110~1116 (2011)
  74. Ngo DH, "Angiotensin-I-converting enzyme(ACE)inhibitory peptides from Pacific cod skin gelatin using ultrafiltration membranes", Process Biochem, 51, pp.1622~1628 (2016)
  75. Nikoo M, "Antioxidant and cryoprotective effects of Amur sturgeon skin gelatin hydrolysate in unwashed fish mince", Food Chem, 181, pp.295~303 (2015)
  76. Nussbaum JM, "Alzheimer disease : a tale of two prions", Prion, 7, pp.14~19 (2013)
  77. Paul M, "Physiology of local renin-angiotensin systems", Physiol Rev, 86, pp.747~803 (2006)
  78. Pei X, "Marine collagen peptide isolated from Chum Salmon(Oncorhynchus keta)skin facilitates learning and memory in aged C57BL", 6J mice, 2010, pp.118, 333~340
  79. Pihlanto-Leppälä A, "Bioactive peptides derived from bovine whey proteins", Trends Food Sci Technol, 11, pp.347~356 (2000)
  80. Pomponi SA, "The bioprocess-technological potential of the sea", Prog Ind Microbiol, 35, pp.5~13 (1999)
  81. Power O, "Food protein hydrolysates as a source of dipeptidyl peptidase IV inhibitory peptides for the management of type 2 diabetes", Proc Nutr Soc, 73, pp.34~46 (2014)
  82. Pulawski W, "Ubiquitous amyloids", Appl Biochem Biotechnol, 166, pp.1626~1643 (2012)
  83. Hee Bong Pyun, "Effects of Collagen Tripeptide Supplement on Photoaging and Epidermal Skin Barrier in UVB-exposed Hairless Mice", Preventive Nutrition and Food Science, 17(4), pp.245~253 (2012), 한국식품영양과학회[DOI]
  84. Reimer RA, "Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is regulated by extracellular signal-regulated kinase1", 2 and p38 mitogenactivated protein kinases, 2006, pp.19, 1159~1170
  85. Rho SJ, "Purification and identification of an angiotensin I-converting enzyme inhibitory peptide from fermented soybean extract", Process Biochem, 44, pp.490~493 (2009)
  86. Rogerson FM, "Presence of angiotensin converting enzyme in the adventitia of large blood vessels", J Hypertens, 10, pp.615~620 (1992)
  87. Rui X, "Purification and characterization of angiotensin I-converting enzyme inhibitory peptides of small red bean(Phaseolus vulgaris)hydrolysates", J Funct Foods, 5, pp.1116~1124 (2013)
  88. Sae-Leaw T, "Purification and identification of antioxidant peptides from gelatin hydrolysate of seabass skin", J Food Biochem, 41, pp.e12350~ (2017)
  89. Saiga A, "Antioxidant activity of peptides obtained from porcine myofibrillar proteins by protease treatment", J Agric Food Chem, 51, pp.3661~3667 (2003)
  90. Sampath Kumar NS, "Purification and identification of antioxidant peptides from the skin protein hydrolysate of two marine fishes, horse mackerel(Magalaspis cordyla)and croaker(Otolithes ruber)", Amino Acids, 5, pp.1641~1649 (2012)
  91. Seo JK, "Antimicrobial function of the GAPDHrelated antimicrobial peptide in the skin of skipjack tuna, Katsuwonus pelamis", Fish Shellfish Immunol, 36, pp.571~581 (2014)
  92. Seo JK, "Purification and characterization of YFGAP, a GAPDH-related novel antimicrobial peptide, from the skin of yellowfin tuna, Thunnus albacares", Fish Shellfish Immunol, 33, pp.743~752 (2012)
  93. Silva RSG, "Characteristics and chemical composition of skins gelatin from cobia(Rachycentron canadum)", LWT Food Sci Technol, 57, pp.580~585 (2014)
  94. Silveira ST, "Dipeptidyl peptidase-IV inhibitory peptides generated by tryptic hydrolysis of a whey protein concentrate rich in β-lactoglobulin", Food Chem, 141, pp.1072~1077 (2013)
  95. Singh P, "Isolation and characterisation of collagen extracted from the skin of striped catfish(Pangasianodon hypophthalmus)", Food Chem, 124, pp.97~105 (2011)
  96. Su Y, "Isolation and identification of pelteobagrin, a novel antimicrobial peptide from the skin mucus of yellow catfish(Pelteobagrus fulvidraco)", Comp Biochem Physiol B Biochem Mol Biol, 158, pp.149~154 (2011)
  97. Sun L, "Antiphotoaging effect and purification of an antioxidant peptide from tilapia(Oreochromis niloticus)gelatin peptides", J Funct Foods, 5, pp.154~162 (2013)
  98. Theodore AE, "Antioxidative activity of protein hydrolysates prepared from alkaline-aided channel catfish protein isolates", J Agric Food Chem, 56, pp.7459~7466 (2008)
  99. Thuanthong M, "Purification and characterization of angiotensin-converting enzyme-inhibitory peptides from Nile tilapia(Oreochromis niloticus)skin gelatine produced by an enzymatic membrane reactor", J Funct Foods, 36, pp.243~254 (2017)
  100. Wang L, "Isolation and characterisation of collagens from the skin, scale and bone of deep-sea redfish(Sebastes mentella)", Food Chem, 108, pp.616~623 (2008)
  101. Wang TY, "Fish skin gelatin hydrolysates as dipeptidyl peptidase IV inhibitors and glucagon-like peptide-1 stimulators improve glycaemic control in diabetic rats : a comparison between warm-and cold-water fish", J Funct, 19, pp.330~340 (2015)
  102. Wu H, "Enzymatic preparation and characterization of ironchelating peptides from anchovy(Engraulis japonicus)muscle protein", Food Res Int, 48, pp.435~441 (2012)
  103. Wu Q, "A novel angiotensin-I converting enzyme(ACE)inhibitory peptide from gastrointestinal protease hydrolysate of silkworm pupa(Bombyx mori)protein : biochemical characterization and molecular docking study", Peptides, 68, pp.17~24 (2015)
  104. Wu W, "Identification of iron-chelating peptides from Pacific cod skin gelatin and the possible binding mode", J Funct Foods, 35, pp.418~427 (2017)
  105. Xu L, "Effect of marine collagen peptides on physiological and neurobehavioral development of male rats with perinatal asphyxia", Mar Drugs, 13, pp.3653~3671 (2015)
  106. Yamamoto N, "Antihypertensive effect of the peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790", J Dairy Sci, 77, pp.917~922 (1994)
  107. Zhang Y, "Purification and characterization of novel antioxidant peptides from enzymatic hydrolysates of tilapia(Oreochromis niloticus)skin gelatin", Peptides, 38, pp.13~21 (2012)

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