뇌내출혈로 입원치료 받던 중 만성B형간염 면역관용기에서 면역활동기로 전환된 환자에 대한 생간탕가감 치험 1례
A Case Report of the Efficacy of Saenggan-tang-gagam in the Treatment of a Patient with Chronic Hepatitis B Who Showed Conversion of the Immune-Tolerant Phase to Immune-Clearance Phase during Hospitalization for Intracerebral Hemorrhage
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Objectives: The purpose of this case report is to describe the efficacy of Saenggan-tang-gagam treatment in a patient with immune-tolerant chronic hepatitis B who converted to the immune active phase during hospitalization for Intracerebral hemorrhage. Methods: A 61-year-old male patient with chronic hepatitis B was hospitalized from July 21, 2016 to October 24, 2016. On September 5, the patient showed fatigue and dyspepsia, and his urine was dark. These symptoms were accompanied by a dramatic elevation of aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) levels. Saenggan-tang-gagam was administered three times a day until the patient was discharged from the hospital. Results: After the Saenggan-tang-gagam treatment, AST and ALP levels decreased significantly, below the upper limit level. In addition, the levels of ALT and GG were significantly decreased. In addition, the fatigue, dyspepsia, and dark urine induced by hepatitis improved after the Saenggan-tang-gagam treatment. Conclusion: This case report suggests that traditional Korean medicine has a beneficial effect on the immune active phase of chronic hepatitis B.
Abstract
Objectives: The purpose of this case report is to describe the efficacy of Saenggan-tang-gagam treatment in a patient with immune-tolerant chronic hepatitis B who converted to the immune active phase during hospitalization for Intracerebral hemorrhage. Methods: A 61-year-old male patient with chronic hepatitis B was hospitalized from July 21, 2016 to October 24, 2016. On September 5, the patient showed fatigue and dyspepsia, and his urine was dark. These symptoms were accompanied by a dramatic elevation of aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) levels. Saenggan-tang-gagam was administered three times a day until the patient was discharged from the hospital. Results: After the Saenggan-tang-gagam treatment, AST and ALP levels decreased significantly, below the upper limit level. In addition, the levels of ALT and GG were significantly decreased. In addition, the fatigue, dyspepsia, and dark urine induced by hepatitis improved after the Saenggan-tang-gagam treatment. Conclusion: This case report suggests that traditional Korean medicine has a beneficial effect on the immune active phase of chronic hepatitis B.
참고문헌 (23)
- Chan Ho Park, "Treatment of Solitary Extramedullary Plasmacytoma of the Stomach with Endoscopic Submucosal Dissection", Gut and Liver, 3(4), pp.334~337 (2009), 거트앤리버 발행위원회
- Ministry of Helalth & Welfare KCfDCaP, "The Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV), 2010" (2012), Ministry of Helalth & Welfare
- Chae HB, "Current status of liver diseases in Korea: hepatitis B", Korean J Hepatol, 15(Suppl 6), pp.S13~S24 (2009)
- 천재희, "단일 기관에서 치료한 간세포암종 1,078예의 임상 백서", Clinical and Molecular Hepatology, 10(2004), pp.288~297 (2004), 대한간학회
- Si Hyun Bae, "Hepatitis B Virus Genotype C Prevails Among Chronic Carriers of the Virus in Korea", Journal of Korean Medical Science, 20(5), pp.816~820 (2005), 대한의학회
- Kim H, "Molecular epidemiology of hepatitis B virus (HBV) genotypes and serotypes in patients with chronic HBV infection in Korea", Intervirology, 50, pp.52~57 (2007)
- Lok AS, "Chronic hepatitis B", Hepatology, 45, pp.507~539 (2007)
- Tran TT, "Immune tolerant hepatitis B: a clinical dilemma", Gastroenterol Hepatol (NY), 7, pp.511~516 (2011)
- Lee PI, "Changes of serum hepatitis B virus DNA and aminotransferase levels during the course of chronic hepatitis B virus infection in children", Hepatology, 12(4 Pt 1), pp.657~660 (1990)
- "Consensus statements on the prevention and management of hepatitis B and hepatitis C in the Asia-Pacific region. Core Working Party for Asia-Pacific Consensus on Hepatitis B and C", J Gastroenterol Hepatol, 15, pp.825~841 (2000)
- Chu CJ, "Quantitative serum HBV DNA levels during different stages of chronic hepatitis B infection", Hepatology, 36, pp.1408~1415 (2002)
- Lok AS, "Chronic hepatitis B: update 2009", Hepatology, 50, pp.661~662 (2009)
- Woo HJ, "Clinical study on differentiation of syndromes of various liver diseases and SGOT", SGPT Ratio, 1986, pp.7(2), 61~69
- Choi SY, "Studies on the Effect of Saengkantang on liver protection, platelet aggregation and general immune-function. College of Oriental Medicine", Kyung Hee Univ Oriental Med J, 10, pp.25~57 (1987)
- 승현석, "가감생간탕 투여후 호전된 급성 간염 2예", 대한한방내과학회지, 23(2), pp.228~237 (2002), 대한한방내과학회
- Korea Centers for Disease Control and Prevention, "2006 Disease Control White Paper", pp.144~ (2007), Korea Centers for Disease Control and Prevention
- Kim BW, "Studies on the Effect of Saengkankunbi-tang on the Metabolism and Regenerative Function in Liver(Biochemical and Electromicroscopic Studies)", Kyung Hee Univ Oriental Med J, 5(1), pp.19~40 (1982)
- Hong MS, "Experimental Studies on the Efficacy of Saenggan-tang", master, pp.1987
- Kim DH, "Clinical Observation of Liver Disease Patients", The journal of KOMS, 8(2), pp.14~23 (1987)
- 신용수, "급성 담낭염 환자의 가감생간탕 치험례", 동의생리병리학회지, 23(6), pp.1465~1469 (2009), 한의병리학회
- Yoon SH, "Response of Kagamseanggantang on the Liver Function in Alcoholic Liver Diseases", KOMS, 14(2), pp.348~354 (1993)
- Ha YD, "Antitumoral, Antioxidant and Antimicrobial Activities of Solvent Ftactions from Grifola umbllatus", The Journal of Korean Society of Food Preservation, 8(4), pp.481~487 (2001)
- 이태수, "저령(Grifola umbellata)에서 추출한 조다당류의 면역활성 및 항암 효과", 한국균학회지, 32(1), pp.23~30 (2004), 한국균학회