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논문KCI 등재

양성 전립선 비대증 유발 쥐에 단미 한약재가 미치는 영향에 관한 연구 분석

Effects of the Korean Medicinal Herbs for Treatment of Benign Prostatic Hyperplasia Induced in Rat Models: A Review

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Objectives: This study is to review the effect of Korean medicinal herbs on treatment of benign prostatic hyperplasia induced in rat models, as reported in domestic and foreign journals. Methods: Six electronic databases (EMBASE, PubMed, Oasis, RISS, CENTRAL, and Koreankt) were searched with terms including benign prostatic hyperplasia to identify study reports on treatment of benign prostatic hyperplasia impairment with Korean medicinal herbs. After selecting several studies, the analysis focused on items reflected in the diagnosis of benign prostatic hyperplasia, such as prostate weight, thickness of the prostate epithelium, and prostate specific antigen. Results: Six studies were reviewed. Testosterone propionate was used as a benign prostatic hyperplasia induction material in all the included studies. Cinnamomum verum (CV), Cynanchum wilfordii (CW), Ponciri fructus (PF), Quisqualis indica (QI), Acorus gramineus (AG), and Melandrium firmum (MF) had reduced prostate weight statistically significantly. The QI gave a better response than finasteride in terms of reducing epithelium thickness, and the response was statistically significant. The prostate specific antigen level was lower in the group treated with CV than in the control group. Conclusions: CV, CW, PF, QI, AG, and MF had distinct therapeutic effects. However it is difficult to determine which of these is better by comparing them numerically because the observation items evaluated in a rat model of benign prostatic hyperplasia.

Abstract

Objectives: This study is to review the effect of Korean medicinal herbs on treatment of benign prostatic hyperplasia induced in rat models, as reported in domestic and foreign journals. Methods: Six electronic databases (EMBASE, PubMed, Oasis, RISS, CENTRAL, and Koreankt) were searched with terms including benign prostatic hyperplasia to identify study reports on treatment of benign prostatic hyperplasia impairment with Korean medicinal herbs. After selecting several studies, the analysis focused on items reflected in the diagnosis of benign prostatic hyperplasia, such as prostate weight, thickness of the prostate epithelium, and prostate specific antigen. Results: Six studies were reviewed. Testosterone propionate was used as a benign prostatic hyperplasia induction material in all the included studies. Cinnamomum verum (CV), Cynanchum wilfordii (CW), Ponciri fructus (PF), Quisqualis indica (QI), Acorus gramineus (AG), and Melandrium firmum (MF) had reduced prostate weight statistically significantly. The QI gave a better response than finasteride in terms of reducing epithelium thickness, and the response was statistically significant. The prostate specific antigen level was lower in the group treated with CV than in the control group. Conclusions: CV, CW, PF, QI, AG, and MF had distinct therapeutic effects. However it is difficult to determine which of these is better by comparing them numerically because the observation items evaluated in a rat model of benign prostatic hyperplasia.

참고문헌 (49)

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관련 논문AI추천

Corni Fructus attenuates testosterone-induced benign prostatic hyperplasia by suppressing 5α-reductase and androgen receptor expression in rats박철, 권다혜, 김경일, 김기영, 김민영, 김범회, 김종식, 박노진, 안규임, 정지숙, 지선영, 최영현, 최은옥, 홍수현, 황보현한국영양학회 · Nutrition Research and Practice2018 · 제12권 제5호薑黃이 고환절제술 및 testosterone으로 유발된 rat의 전립선비대증에 미치는 영향김영옥, 안세영, 안영민, 이병철, 이상헌대한한방내과학회 · 대한한방내과학회지2009 · 제30권 제2호海金沙가 Rat의 전립선비대에 미치는 영향김용성, 이두현, 이장식대한한방내과학회 · 대한한방내과학회지2010 · 제31권 제3호蜂毒藥鍼이 前立腺肥大症 Rat에 미치는 영향김용성, 조소현, 한양희대한한방내과학회 · 대한한방내과학회지2010 · 제31권 제1호Mixture of Corni Fructus and Schisandrae Fructus improves testosterone-induced benign prostatic hyperplasia through regulating 5α-reductase 2 and androgen receptor김기영, 최영현, Hwangbo Hyun, Ji Seon Yeong, Jung Haeun, Kim Hyunjin, Kim Min Yeong, Kim Sung Yeon, Kim TaeHee, Kim Taeiung, Lee Hyesook, Park Beom Su, Yoon Seonhye한국영양학회 · Nutrition Research and Practice2023 · 제17권 제1호The combination of water extracts of Curcumae Radix and Syzygii Flos improves benign prostatic hyperplasia by suppressing testosterone-induced proliferation of prostate cells in vivo and in vitro곽현정, 박자연, Beomsu Lee, Gahee Song, Jae-Young Um, Jinbong Park, Kwang Seok Ahn, Woo Yong Park, Yunu Jung한국영양학회 · Nutrition Research and Practice2025 · 제19권 제3호

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