본문 바로가기
KERD
논문KCI 등재

Corni Fructus attenuates testosterone-induced benign prostatic hyperplasia by suppressing 5α-reductase and androgen receptor expression in rats

2

조회

0

다운로드

10

인용

0

참고문헌

키워드

초록

BACKGROUND/OBJECTIVES: Benign prostatic hypertrophy (BPH) is a major cause of abnormal overgrowth of the prostate mainly in the elderly. Corni Fructus has been reported to be effective in the prevention and treatment of various diseases because of its strong antioxidant effect, but its efficacy against BPH is not yet known. This study was designed to evaluate the therapeutic efficacy of Corni Fructus water extract (CF) in testosterone-induced BPH rats. MATERIALS/METHODS: To induce BPH, rats were intraperitoneal injected with testosterone propionate (TP). Rats in the treatment group were orally administered with CF with TP injection, and finasteride, which is a selective inhibitor of 5α-reductase type 2, was used as a positive control. RESULTS: Our results showed that the increased prostate weight and histopathological changes in BPH model rats were suppressed by CF treatment. CF, similar to the finasteride-treated group, decreased the levels of testosterone and dihydrotestosterone by TP treatment in the serum, and it also reduced 5α-reductase expression and concentration in prostate tissue and serum, respectively. In addition, CF significantly blocked the expression of the androgen receptor (AR), AR co-activators, and proliferating cell nuclear antigen in BPH rats, and this blocking was associated with a decrease in prostate-specific antigen levels in serum and prostate tissue. CONCLUSIONS: These results suggest that CF may weaken the BPH status through the inactivation of at least 5α-reductase and AR activity and may be useful for the clinical treatment of BPH.

Abstract

BACKGROUND/OBJECTIVES: Benign prostatic hypertrophy (BPH) is a major cause of abnormal overgrowth of the prostate mainly in the elderly. Corni Fructus has been reported to be effective in the prevention and treatment of various diseases because of its strong antioxidant effect, but its efficacy against BPH is not yet known. This study was designed to evaluate the therapeutic efficacy of Corni Fructus water extract (CF) in testosterone-induced BPH rats. MATERIALS/METHODS: To induce BPH, rats were intraperitoneal injected with testosterone propionate (TP). Rats in the treatment group were orally administered with CF with TP injection, and finasteride, which is a selective inhibitor of 5α-reductase type 2, was used as a positive control. RESULTS: Our results showed that the increased prostate weight and histopathological changes in BPH model rats were suppressed by CF treatment. CF, similar to the finasteride-treated group, decreased the levels of testosterone and dihydrotestosterone by TP treatment in the serum, and it also reduced 5α-reductase expression and concentration in prostate tissue and serum, respectively. In addition, CF significantly blocked the expression of the androgen receptor (AR), AR co-activators, and proliferating cell nuclear antigen in BPH rats, and this blocking was associated with a decrease in prostate-specific antigen levels in serum and prostate tissue. CONCLUSIONS: These results suggest that CF may weaken the BPH status through the inactivation of at least 5α-reductase and AR activity and may be useful for the clinical treatment of BPH.

참고문헌 (41)

  1. Cornu JN, "A systematic review and meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic obstruction: an update", Eur Urol, 67, pp.1066~1096 (2015)[DOI]
  2. Pyo JS, "Systematic review and meta-analysis of prostatic artery embolisation for lower urinary tract symptoms related to benign prostatic hyperplasia", Clin Radiol, 72, pp.16~22 (2017)[DOI]
  3. Aaron L, "Review of prostate anatomy and embryology and the etiology of benign prostatic hyperplasia", Urol Clin North Am, 43, pp.279~288 (2016)[DOI]
  4. Strand DW, "Targeting phenotypic heterogeneity in benign prostatic hyperplasia", Differentiation, 96, pp.49~61 (2017)[DOI]
  5. Vignozzi L, "Benign prostatic hyperplasia: a new metabolic disease?", J Endocrinol Invest, 37, pp.313~322 (2014)[DOI]
  6. Steers WD, "5alpha-reductase activity in the prostate", Urology, 58, pp.17~24 (2001)[DOI]
  7. Nicholson TM, "Androgens and estrogens in benign prostatic hyperplasia: past, present and future", Differentiation, 82, pp.184~199 (2011)[DOI]
  8. Andriole G, "Dihydrotestosterone and the prostate: the scientific rationale for 5alpha-reductase inhibitors in the treatment of benign prostatic hyperplasia", J Urol, 172, pp.1399~1403 (2004)[DOI]
  9. Azzouni F, "Role of <TEX>$5{\alpha}$<", TEX>-reductase inhibitors in benign prostatic diseases, 2012, pp.15, 222~230
  10. Gharaee-Kermani M, "Promising molecular targets and biomarkers for male BPH and LUTS", Curr Urol Rep, 14, pp.628~637 (2013)[DOI]
  11. Ho CK, "Estrogen and androgen signaling in the pathogenesis of BPH", Nat Rev Urol, 8, pp.29~41 (2011)[DOI]
  12. Thorner DA, "Benign prostatic hyperplasia: symptoms, symptom scores, and outcome measures", Urol Clin North Am, 36, pp.417~429 (2009)[DOI]
  13. Smith RD, "Transurethral resection of the prostate revisited and updated", Curr Opin Urol, 21, pp.36~41 (2011)[DOI]
  14. Traish AM, "Adverse effects of <TEX>$5{\alpha}$<", TEX>-reductase inhibitors: what do we know, don't know, and need to know?, 2015, pp.16, 177~198
  15. Lepor H, "Alpha-blockers for the treatment of benign prostatic hyperplasia", Urol Clin North Am, 43, pp.311~323 (2016)[DOI]
  16. Chang JS, "Chemoprevention against hepatocellular carcinoma of Cornus officinalis in vitro", Am J Chin Med, 32, pp.717~725 (2004)[DOI]
  17. Kang DG, "Cornuside suppresses cytokine-induced proinflammatory and adhesion molecules in the human umbilical vein endothelial cells", Biol Pharm Bull, 30, pp.1796~1799 (2007)[DOI]
  18. Jiang WL, "Cornuside attenuates apoptosis and ameliorates mitochondrial energy metabolism in rat cortical neurons", Pharmacology, 84, pp.162~170 (2009)[DOI]
  19. Jeong EJ, "Neuroprotective iridoid glycosides from Cornus officinalis fruits against glutamate-induced toxicity in HT22 hippocampal cells", Phytomedicine, 19, pp.317~321 (2012)[DOI]
  20. Telang NT, "Anti- proliferative effects of Chinese herb Cornus officinalis in a cell culture model for estrogen receptor-positive clinical breast cancer", Mol Med Rep, 5, pp.22~28 (2012)
  21. Zhang QC, "Antiplatelet activity of a novel formula composed of malic acid, succinic acid and citric acid from Cornus officinalis fruit", Phytother Res, 27, pp.1894~1896 (2013)[DOI]
  22. Sun X, "Protective effect of Fructus corni polysaccharide on hippocampal tissues and its relevant mechanism in epileptic rats induced by lithium chloride-pilocarpine", Exp Ther Med, 16, pp.445~451 (2018)
  23. Hwang KA, "Antioxidant activities and oxidative stress inhibitory effects of ethanol extracts from Cornus officinalis on raw 264.7 cells", BMC Complement Altern Med, 16, pp.196~ (2016)[DOI]
  24. Park JY, "A new secoiridoid glycoside from the fruits of Cornus officinalis (Cornaceae)", Nat Prod Res, 30, pp.1504~1510 (2016)[DOI]
  25. Yoon JH, "p-Coumaric acid and ursolic acid from Corni fructus attenuated <TEX>${\beta}$<", TEX>-amyloid(25-35)-induced toxicity through regulation of the <TEX>$NF-{\kappa}B$<, J Agric Food Chem, pp.2014, 62[DOI]
  26. Ma W, "Bioactive compounds from Cornus officinalis fruits and their effects on diabetic nephropathy", J Ethnopharmacol, 153, pp.840~845 (2014)[DOI]
  27. Minciullo PL, "Oxidative stress in benign prostatic hyperplasia: a systematic review", Urol Int, 94, pp.249~254 (2015)[DOI]
  28. Bostanci Y, "Correlation between benign prostatic hyperplasia and inflammation", Curr Opin Urol, 23, pp.5~10 (2013)[DOI]
  29. Keam SJ, "Dutasteride: a review of its use in the management of prostate disorders", Drugs, 68, pp.463~485 (2008)[DOI]
  30. Traish AM, "<TEX>$5{\alpha}$<", TEX>-reductases in human physiology: an unfolding story, 2012, pp.18, 965~975
  31. Pihlajamaa P, "Determinants of receptor- and tissue-specific actions in androgen signaling", Endocr Rev, 36, pp.357~384 (2015)[DOI]
  32. Robins DM, "Androgen receptor and molecular mechanisms of male-specific gene expression", Novartis Found Symp, 268, pp.42~52 (2005)
  33. Prins GS, "Molecular biology of the androgen receptor", Mayo Clin Proc, 75(Suppl), pp.S32~S35 (2000)
  34. Watanabe M, "Malignant phyllodes tumor of the prostate: retrospective review of specimens obtained by sequential transurethral resection", Pathol Int, 52, pp.777~783 (2002)[DOI]
  35. Cunha GR, "Estrogenic effects on prostatic differentiation and carcinogenesis", Reprod Fertil Dev, 13, pp.285~296 (2001)[DOI]
  36. Huang J, "Ethnopharmacology, phytochemistry, and pharmacology of Cornus officinalis Sieb. et Zucc", J Ethnopharmacol, 213, pp.280~301 (2018)[DOI]
  37. Park CH, "Beneficial effect of 7-O-galloyl-D-sedoheptulose, a polyphenol isolated from Corni fructus, against diabetes-induced alterations in kidney and adipose tissue of type 2 diabetic db", db mice, 2013, pp.2013, 736856~
  38. Vareed SK, "Lipid peroxidation, cyclooxygenase enzyme and tumor cell proliferation inhibitory compounds in Cornus kousa fruits", Phytomedicine, 14, pp.706~709 (2007)[DOI]
  39. Wang W, "Morroniside protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide-induced cytotoxicity", Eur J Pharmacol, 613, pp.19~23 (2009)[DOI]
  40. Xu H, "Morroniside and loganin extracted from Cornus officinalis have protective effects on rat mesangial cell proliferation exposed to advanced glycation end products by preventing oxidative stress", Can J Physiol Pharmacol, 84, pp.1267~1273 (2006)[DOI]
  41. Xu YD, "Neuroprotective effects of loganin on MPTP-induced Parkinson's disease mice: neurochemistry, glial reaction and autophagy studies", J Cell Biochem, 118, pp.3495~3510 (2017)[DOI]

관련 논문AI추천

Mixture of Corni Fructus and Schisandrae Fructus improves testosterone-induced benign prostatic hyperplasia through regulating 5α-reductase 2 and androgen receptor김기영, 최영현, Hwangbo Hyun, Ji Seon Yeong, Jung Haeun, Kim Hyunjin, Kim Min Yeong, Kim Sung Yeon, Kim TaeHee, Kim Taeiung, Lee Hyesook, Park Beom Su, Yoon Seonhye한국영양학회 · Nutrition Research and Practice2023 · 제17권 제1호Asparagi radix alleviates testosterone-induced benign prostatic hyperplasia by inhibiting 5α-reductase activity and androgen receptor signaling pathway김기영, 김다혜, 노정숙, 문성권, 최영현, Hee-Jae Cha, Heui-Soo Kim, Hyun HwangBo, Ji Seon Yeong, Kim Min Yeong, Tae Hee Kim한국영양학회 · Nutrition Research and Practice2024 · 제18권 제6호Corn silk extract improves benign prostatic hyperplasia in experimental rat model강현중, 김명환, 김선림, 김소라, 김우경, 최현지, 하애화한국영양학회 · Nutrition Research and Practice2017 · 제11권 제5호The combination of water extracts of Curcumae Radix and Syzygii Flos improves benign prostatic hyperplasia by suppressing testosterone-induced proliferation of prostate cells in vivo and in vitro곽현정, 박자연, Beomsu Lee, Gahee Song, Jae-Young Um, Jinbong Park, Kwang Seok Ahn, Woo Yong Park, Yunu Jung한국영양학회 · Nutrition Research and Practice2025 · 제19권 제3호Effect of Phellius linteus water extract on benign prostatic hyperplasia김민선, 김유나, 전성식, 최정화한국영양학회 · Nutrition Research and Practice2013 · 제7권 제3호양성 전립선 비대증 유발 쥐에 단미 한약재가 미치는 영향에 관한 연구 분석배인숙, 정승현대한한방내과학회 · 대한한방내과학회지2018 · 제39권 제4호

이 간행물의 다른 논문 (10건)