Complete genome sequence of potential probiotic Ligilactobacillus ruminis CACC881 isolated from swine
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Ligilactobacillus ruminis is a gram-positive anaerobic bacterium in the host intestinal tract. L. ruminis has not been extensively studied, resulting in limited data regarding its potential probiotic properties and genomic information. In this study, the genome of L. ruminis CACC881 was comprehensively analyzed, resulting in the prediction of potential probiotic characteristics. Additionally, a comparative genomic analysis was conducted on the five L. ruminis strains. The genome of strain CACC881 comprised one circular chromosome 2,107,343 bp in length. Among the predicted 1,935 protein-coding genes, the genome included genes associated with potential probiotic properties, such as acid/bile salt tolerance, clustered regularly interspaced short palindromic repeats (CRISPR)-related genes, and vitamin B-group genes. Notably, the genes for bacteriocin regulation/immunity (nisK and nisI) and antioxidant activity (ahpC) were exclusively found in strain CACC881, while absent in the other four L. ruminis genomes. These findings suggest that L. ruminis CACC881 is a potential probiotic with applications for the animal industry.
Abstract
Ligilactobacillus ruminis is a gram-positive anaerobic bacterium in the host intestinal tract. L. ruminis has not been extensively studied, resulting in limited data regarding its potential probiotic properties and genomic information. In this study, the genome of L. ruminis CACC881 was comprehensively analyzed, resulting in the prediction of potential probiotic characteristics. Additionally, a comparative genomic analysis was conducted on the five L. ruminis strains. The genome of strain CACC881 comprised one circular chromosome 2,107,343 bp in length. Among the predicted 1,935 protein-coding genes, the genome included genes associated with potential probiotic properties, such as acid/bile salt tolerance, clustered regularly interspaced short palindromic repeats (CRISPR)-related genes, and vitamin B-group genes. Notably, the genes for bacteriocin regulation/immunity (nisK and nisI) and antioxidant activity (ahpC) were exclusively found in strain CACC881, while absent in the other four L. ruminis genomes. These findings suggest that L. ruminis CACC881 is a potential probiotic with applications for the animal industry.