통합암치료를 적용한 난소암 뇌, 척추전이 환자의 5년 추적관찰 증례보고
Five-Year Follow-up of an Ovarian Cancer Patient with Brain and Vertebral Metastasis Using Integrative Cancer Treatment: A Case Report
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초록
Objectives: This long-term case report presents the case of an ovarian cancer patient with brain, cervical lymph node, and vertebral metastasis suppressed by traditional Korean medicine in combination with cytokine-induced killer (CIK) cell-based immunotherapy. Methods: The patient received acupuncture, moxibustion, GunChil-go, Hangam-dan, and CIK cell-based immunotherapy. The Eastern Cooperative Oncology Group and tumor markers were used to evaluate the treatment effects. Results: Integrative cancer treatment suppressed the progression of cancer, and the patient achieved eight-year survival. The performance status improved, and the tumor marker level was maintained. Conclusions: We suggest that an integrative cancer treatment that includes traditional Korean medicine can be a meaningful treatment option for advanced ovarian cancer.
Abstract
Objectives: This long-term case report presents the case of an ovarian cancer patient with brain, cervical lymph node, and vertebral metastasis suppressed by traditional Korean medicine in combination with cytokine-induced killer (CIK) cell-based immunotherapy. Methods: The patient received acupuncture, moxibustion, GunChil-go, Hangam-dan, and CIK cell-based immunotherapy. The Eastern Cooperative Oncology Group and tumor markers were used to evaluate the treatment effects. Results: Integrative cancer treatment suppressed the progression of cancer, and the patient achieved eight-year survival. The performance status improved, and the tumor marker level was maintained. Conclusions: We suggest that an integrative cancer treatment that includes traditional Korean medicine can be a meaningful treatment option for advanced ovarian cancer.
참고문헌 (31)
- Annual report of cancer statistics in Korea in 2021, "The Korea Central Cancer Registry, National Cancer Center", Ministry of Health and Welfare, ~ (2023)
- Siegel RL, "Cancer statistics, 2020", CA Cancer J Clin, 70(1), pp.7~30 (2020)
- Modugno F, "Ovarian cancer:Prevention, detection, and treatment of the disease and its recurrence. Molecular mechanisms and personalized medicine meeting report", Int J Gynecol Cancer, 22(8), pp.1~22 (2012)
- Lheureux S, "Epithelial ovarian cancer", Lancet, 393(10177), pp.1240~1253 (2019)
- 노재홍, "불완전한 병기결정 수술 후 발견된 난소암의 치료", Journal of Gynecologic Oncology, 18(3), pp.195~200 (2007), 대한부인종양학회
- Le T, "The benefits of comprehensive surgical staging in the management of early-stage epithelial ovarian carcinoma", Gynecol Oncol, 85(2), pp.351~355 (2002)
- 임명철, "난소암의 항암요법", 대한의사협회지, 59(3), pp.175~179 (2016), 대한의사협회[DOI]
- Kang SH, "Allergen-Removed Rhus verniciflua Extract Induces Ovarian Cancer Cell Death via JNK Activation", Am J Chin Med, 44(8), pp.1719~1735 (2016)
- Jang HJ, "Cordycepin inhibits human ovarian cancer by inducing autophagy and apoptosis through Dickkopf-related protein 1", β-catenin signaling, 2019, pp.11(11), 6890~6906
- Baiocchi G, "Surgical implications of mesenteric lymph node metastasis from advanced ovarian cancer after bowel resection", J Surg Oncol, 104(3), pp.250~254 (2011)
- Picaud L, "Evaluation of the effects of hyaluronic acid-carboxymethyl cellulose barrier on ovarian tumor progression", J Ovarian Res, 7, pp.40~ (2014)
- Chéreau E, "Advanced ovarian cancer : criteria of resectability", Bull Cancer, 96(12), pp.1189~1197 (2009)
- 최주혁, "난소암 세포주에서 클러스터린의 항암제 결합과 항암제 내성의 연관성", Obstetrics & Gynecology Science, 51(7), pp.738~743 (2008), 대한산부인과학회
- Salani R, "Posttreatment surveillance and diagnosis of recurrence in women with gynecologic malignancies : Society of Gynecologic Oncologists recommendations", Am J Obstet Gynecol, 204(6), pp.466~478 (2011)
- Armstrong DK, "Intraperitoneal cisplatin and paclitaxel in ovarian cancer", N Engl J Med, 354(1), pp.34~43 (2006)
- Trimbos JB, "International Collaborative Ovarian Neoplasm trial 1 and Adjuvant ChemoTherapy In Ovarian Neoplasm trial : two parallel randomized phase III trials of adjuvant chemotherapy in patients with early-stage ovarian carcinoma", J Natl Cancer Inst, 95(2), pp.105~112 (2003)
- Chan KKL, "The use of Chinese herbal medicine to improve quality of life in women undergoing chemotherapy for ovarian cancer : a double-blind placebo-controlled randomized trial with immunological monitoring", Ann Oncol Off J Eur Soc Med Oncol, 22(10), pp.2241~2249 (2011)
- Wu YH, "Use of Chinese Herbal Medicine Improves Chemotherapy-Induced Thrombocytopenia among Gynecological Cancer Patients : An Observational Study", Evid Based Complement Alternat Med, 2018, pp.4201325~ (2018)
- Wang R, "Efficacy and Safety of Chinese Herbal Medicine on Ovarian Cancer After Reduction Surgery and Adjuvant Chemotherapy : A Systematic Review and Meta-Analysis", Front Oncol, 9, pp.730~ (2019)
- 김경순, "난소암 치료에 대한 한의 임상 가이드라인", 대한암한의학회지, 21(2), pp.37~50 (2016), 대한암한의학회[DOI]
- 이남헌, "항암단으로 치료한 암환자 100례의 혈청 VFGF, bEGF 및 platelet 수치 변화", 대한한방내과학회지, 26(4), pp.753~760 (2005), 대한한방내과학회
- 유화승, "각종 암환자 69례에 대한 항전이 및 재발억제 효과", 대한한방내과학회지, 23(2), pp.165~173 (2002), 대한한방내과학회
- Yoo HS, "Antitumor effects of HangAmDan(HAD)on 55 patients with advanced gastric cancer", J Korean Med, 2(1), pp.77~88 (2001)
- Lee YY, "The Clinical study in 83 cases for colorectal cancer patients on the effects by Hangamdan(抗癌丹)", Journal of Korean Traditional Oncology, 6(1), pp.165~180 (2000)
- Choi WC, "Rhus verniciflua stokes against advanced cancer : A perspective from the korean integrative cancer center", J Biomed Biotechnol, 2012, pp.874276~ (2012)
- 안정좌, "Ultrafine particles of Ulmus davidiana var. japonica induce apoptosis of gastric cancer cells via activation of caspase and endoplasmic reticulum stress", Archives of Pharmacal Research, 37(6), pp.783~792 (2014), 대한약학회
- Jin UH, "Induction of mitochondria-mediated apoptosis by methanol fraction of Ulmus davidiana Planch(Ulmaceae)in U87 glioblastoma cells", Environ Toxicol Pharmacol, 22(2), pp.136~141 (2006)
- 백일성, "AGS 인체위암세포에서 건칠, 유근피 및 신석 추출물의 항암 활성 비교 연구", 생명과학회지, 25(8), pp.849~860 (2015), 한국생명과학회
- 김종윤, "PubMed 검색을 통한 항암화학요법 부작용 관련 침 임상시험 현황 고찰", Journal of Acupuncture Research, 30(2), pp.43~53 (2013), 대한침구의학회
- 윤해창, "암 환자에 대한 구법의 치료와 메커니즘에 대한 최신 국내외 연구 현황", 대한한방내과학회지, 36(3), pp.361~379 (2015), 대한한방내과학회
- Zhang Y, "Ten-year update of the international registry on cytokine-induced killer cells in cancer immunotherapy", J Cell Physiol, 235(12), pp.9291~9303 (2020)
