Herbal Medicines for the Improvement of Immune Function in Patients with Cancer: A Protocol for Systematic Review and Meta-Analysis
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: Patients with cancer eventually fail to respond to therapy when malignant cells develop effective ways to evade immunosurveillance. Conventional cancer treatments, such as radiation therapy and chemotherapy, aim to cure the disease or prolong the patient’s life. However, the toxicity and side effects of conventional treatments limit their efficacy. Herbal medicine is a typical complementary and integrative form of medicine for cancer treatment in Asia. This protocol evaluates the effectiveness of herbal medicines in improving the immune function of patients with cancer. Methods: The following electronic databases will be searched: MEDLINE via PubMed, EMBASE via Elsevier, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI), and Korean databases including Regional Information Sharing Systems (RISS), National Digital Science Library (NDSL), and Oriental Medicine Advanced Searching Integrated System (OASIS). Additionally, prospective randomized controlled trials that evaluate the effectiveness of herbal medicines on immune function in patients with cancer will be included in this review. All outcomes related to the immune function of patients with cancer (e.g., CD3, CD4, CD8, CD4/CD8 ratio, CD19 (B cells), dendritic cells (CD11), CD56 (NK cells), and macrophages) will be included in this review. Results: This review is expected to provide data on the effectiveness of herbal medicines on improving immune functions in patients with cancers. Conclusion: This systematic review will help patients and clinicians establish new management options for cancer treatment.
Abstract
Objectives: Patients with cancer eventually fail to respond to therapy when malignant cells develop effective ways to evade immunosurveillance. Conventional cancer treatments, such as radiation therapy and chemotherapy, aim to cure the disease or prolong the patient’s life. However, the toxicity and side effects of conventional treatments limit their efficacy. Herbal medicine is a typical complementary and integrative form of medicine for cancer treatment in Asia. This protocol evaluates the effectiveness of herbal medicines in improving the immune function of patients with cancer. Methods: The following electronic databases will be searched: MEDLINE via PubMed, EMBASE via Elsevier, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI), and Korean databases including Regional Information Sharing Systems (RISS), National Digital Science Library (NDSL), and Oriental Medicine Advanced Searching Integrated System (OASIS). Additionally, prospective randomized controlled trials that evaluate the effectiveness of herbal medicines on immune function in patients with cancer will be included in this review. All outcomes related to the immune function of patients with cancer (e.g., CD3, CD4, CD8, CD4/CD8 ratio, CD19 (B cells), dendritic cells (CD11), CD56 (NK cells), and macrophages) will be included in this review. Results: This review is expected to provide data on the effectiveness of herbal medicines on improving immune functions in patients with cancers. Conclusion: This systematic review will help patients and clinicians establish new management options for cancer treatment.
참고문헌 (18)
- "GLOBOCAN 2020: New Global Cancer Data |UICC"[URL]
- "World Cancer Day 2022 - IARC"[URL]
- Bray F, "International Bank for Reconstruction and Development" (2015), World Bank
- "Traditional Chinese medicine in cancer care: a review of case series published in the Chinese literature"[URL]
- Crawford J, "Chemotherapy-induced neutropenia : risks, consequences, and new directions for its management", Cancer, 100(2), pp.228~237 (2004)
- D’Errico G, "A current perspective on cancer immune therapy : step-by-step approach to constructing the magic bullet", Clin Transl Med, 6(1), pp.3~ (2017)[DOI]
- Bagchi S, "Immune checkpoint inhibitors for the treatment of cancer : clinical impact and mechanisms of response and resistance", Annu Rev Pathol, 16, pp.223~249 (2021)[DOI]
- Qi F, "Chinese herbal medicines as adjuvant treatment during chemo-or radio-therapy for cancer", BioSci Trends, 4(6), pp.297~307 (2010)
- Wang Y, "Antitumor effects of immunityenhancing traditional Chinese medicine", Biomed Pharmacother, 121, pp.109570~ (2020)
- Jung SJ, "Immunomodulatory effects of a mycelium extract of Cordyceps(Paecilomyces hepiali; CBG-CS-2) : a randomized and doubleblind clinical trial", BMC Complement Altern Med, 19(1), pp.77~ (2019)[DOI]
- Shamseer L, "Preferred reporting items for systematic review and meta-analysis protocols(PRISMA-P)2015 : elaboration and explanation", BMJ, 350, pp.g7647~ (2015)
- Cumpston M, "Updated guidance for trusted systematic reviews : a new edition of the Cochrane Handbook for Systematic Reviews of Interventions", Cochrane Database Syst Rev, 10(10), pp.ED000142~ (2019)[DOI]
- Li S, "Chinese herbal medicine for reducing chemotherapy-associated side-effects in breast cancer patients : a systematic review and metaanalysis", Front Oncol, 10, pp.599073~ (2020)
- Lee JY, "Traditional herbal medicine, Sipjeondaebo-Tang, for cancer-related fatigue : a randomized, placebocontrolled, preliminary study", Integr Cancer Ther, 20, pp.15347354211040830~ (2021)
- "Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine | EndNote Click"[URL]
- Chen Z, "Astragali Radix(Huangqi) : A promising edible immunomodulatory herbal medicine", J Ethnopharmacol, 258, pp.112895~ (2020)
- Tang H, "Immunotherapy and tumor microenvironment", Cancer Lett, 370(1), pp.85~90 (2016)[DOI]
- Zhang Y, "Research status and molecular mechanism of the traditional chinese medicine and antitumor therapy combined strategy based on tumor microenvironment", Front Immunol, 11, pp.609705~ (2021)[DOI]