뇌혈관질환 환자에 대한 청심연자탕(淸心連子湯), 도담탕(導痰湯), 혈부축어탕(血府逐瘀湯), 보신익뇌탕(補腎益腦湯)의 간기능과 신기능 안전성 평가 : 후향적 연구
Hepatic/Renal Safety Evaluation of Cheongsimyeonja-tang (Qīngxīn Liánzǎo Tāng), Dodam-tang (Táodàn Tāng), Hyeolbuchukso-tang (Xuè Fǔ Zhú Yū Tāng), and Boshiniknai-tang (Bǔ Shèn Yì Nǎo Tāng) for Cerebrovascular Diseases: A Retrospective Study
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Objectives: As Korea transitions into an aging society, the incidence of cerebrovascular disease is expected to increase. Herbal medicine is commonly used in Oriental medicine to treat cerebrovascular disease. However, there is insufficient clinical evidence to actively support the safety of herbal medicine in clinical practice. Therefore, the aim of this study was to determine the toxicity and safety of four herbal medicines (Cheongsimyeonja-tang, Dodam-tang, Hyeolbuchukso-tang, and Boshiniknai-tang) in patients with cerebrovascular disease. Methods: This study used electronic medical records to analyze patients admitted to an oriental medicine hospital from April 1, 2017, to December 31, 2020. Liver and renal function values at the time of admission and discharge were compared. Results: A total of 25 patients were included in this study. We found no significant differences in various variables, such as complete blood count, liver-renal function test, and urine, before and after the administration of the four herbal medicines. Additionally, no significant adverse events related to herbal medicine were observed. Conclusions: This study confirmed the safety of the four herbal medicines in patients with cerebrovascular disease who were hospitalized in a single Oriental medicine hospital.
Abstract
Objectives: As Korea transitions into an aging society, the incidence of cerebrovascular disease is expected to increase. Herbal medicine is commonly used in Oriental medicine to treat cerebrovascular disease. However, there is insufficient clinical evidence to actively support the safety of herbal medicine in clinical practice. Therefore, the aim of this study was to determine the toxicity and safety of four herbal medicines (Cheongsimyeonja-tang, Dodam-tang, Hyeolbuchukso-tang, and Boshiniknai-tang) in patients with cerebrovascular disease. Methods: This study used electronic medical records to analyze patients admitted to an oriental medicine hospital from April 1, 2017, to December 31, 2020. Liver and renal function values at the time of admission and discharge were compared. Results: A total of 25 patients were included in this study. We found no significant differences in various variables, such as complete blood count, liver-renal function test, and urine, before and after the administration of the four herbal medicines. Additionally, no significant adverse events related to herbal medicine were observed. Conclusions: This study confirmed the safety of the four herbal medicines in patients with cerebrovascular disease who were hospitalized in a single Oriental medicine hospital.
참고문헌 (26)
- Feigin VL, "Global and regional burden of stroke during 1990-2010 : findings from the Global Burden of Disease Study 2010", The Lancet, 383(9913), pp.245~255 (2014)
- Clinical research center for stroke, "Korean Clinical Practice Guidelines for Stroke(revisededition)", Clinical research center for stroke, ~ (2013)
- Lee WM, "Recognizing drug-induced liver injury : Current problem, possible solution", Toxicol Pathol, 33(1), pp.155~164 (2005)
- 김동민, "1개월 이상 한약을 복용한 101명의 간기능 검사에 대한 후향적 관찰", 대한한의학회지, 31(2), pp.149~157 (2010), 대한한의학회
- Kim NH, "Liver enzyme abnormalities during concurrent use of herbal and conventional medicines in Korea : a retrospective study", Phytomedicine, 18(14), pp.1208~1213 (2011)[DOI]
- Kim JS, "Safety of prescribed herbal medicines for hepatic and renal function of polypharmacy patients with stroke: A single-center retrospective study", Medicine (Baltimore), 101(48), pp.e32147~ (2022)
- Lee SH, "Safety of co-administration of herbal and conventional medicines on liver and kidney function in stroke patients : A single-center retrospective study", Phytomedicine, 81, pp.153435~ (2021)
- 서희정, "뇌혈관질환에 대한 다빈도 처방 한약의 임상적 유효성 : 후향적 연구", 대한한방내과학회지, 40(6), pp.1063~1080 (2019), 대한한방내과학회[DOI]
- Benichou C, "Criteria of drug-induced liver disorders Report of an International Consensus Meeting", J Hepatol, 11(2), pp.272~276 (1990)
- Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group, "KDIGO clinical practice guideline for acute kidney injury", Kidney Int, 2(Suppl 1), pp.1~138 (2012)
- Martino R, "Dysphagia after stroke : incidence, diagnosis, and pulmonary complications", Stroke, 36(12), pp.2756~2763 (2005)
- Brown RD, "Stroke incidence, prevalence, and survival : secular trends in Rochester, Minnesota, through 1989", Stroke, 27(3), pp.373~380 (1996)
- American Heart Association, "Heart Disease and Stroke Statistics-2004 Update", Tex American Heart Association, ~ (2003)
- Global Health Estimates 2016: Cause-specific mortality, 2000-2016, "WHO", ~ (2017)
- 양준모, "장기간 한약복용이 부인과 환자의 간 및 신장기능에 미치는 영향: panel연구- 복용 전과 후 3, 6개월 비교를 중심으로-", 대한한의학회지, 41(1), pp.84~92 (2020), 대한한의학회[DOI]
- Lee HU, "Comparison of Liver Function and Kidney Function Test Score by Administration Period of Herbal Medication", The Journal of Internal Korean Medicine, (fal) (2006)
- 배수현, "한방병원 입원환자의 한⋅양방 약물 병용에 따른 간 기능 안전성 평가 : 전향적 관찰연구", 대한한방내과학회지, 34(2), pp.192~203 (2013), 대한한방내과학회
- 윤영주, "한약 복용이 간기능에 미치는 영향: 국내 문헌에 대한 체계적 고찰", 대한한방내과학회지, 30(1), pp.153~172 (2009), 대한한방내과학회
- Wang HL, "Efficacy and Safety of Chinese Herbal Medicine for Primary Intracerebral Hemorrhage : A Systematic Review of Randomized Controlled Trials", Front Pharmacol, 10, pp.1139~ (2019)
- 안다영, "청심연자탕의 연구 동향", 사상체질의학회지, 30(3), pp.1~23 (2018), 사상체질의학회[DOI]
- 진성은, "열다한소탕과 청심연자탕의 Cytochrome P450 활성 연구", 사상체질의학회지, 24(4), pp.84~91 (2012), 사상체질의학회[DOI]
- 마진열, "Mouse에 있어서 시험물질 淸心蓮子湯 추출액의 급성독성 시험", 사상체질의학회지, 22(1), pp.59~65 (2010), 사상체질의학회
- 김영중, "Quatification of Flavonoid Contents in Chungsimyeonja-tang, a Multi-Herbal Decoction, and Its Protective Effect against Cisplatin-induced Nephrotoxicity", Natural Product Sciences, 20(4), pp.251~257 (2014), 한국생약학회
- 한윤희, "청심연자탕 복용이 한방병원 입원환자의 간 기능에 미치는 영향", 대한한방내과학회지, 40(6), pp.1035~1042 (2019), 대한한방내과학회[DOI]
- 이범준, "동맥경화증이 유발된 ApoE^((-", -)) mouse에서 血府逐瘀湯과 Aspirin의 병용투여 효과에 대한 연구, 2011, pp.32(1), 164~174[DOI]
- 서형범, "한약복용이 한방병원 입원환자의 간 기능에 미치는 영향에 대한 후향적 관찰", 대한한방내과학회지, 40(6), pp.1145~1151 (2019), 대한한방내과학회[DOI]