청심연자탕 복용이 한방병원 입원환자의 간 기능에 미치는 영향
Influence of Cheongsimyeonja-tang on the Liver Function of Inpatients at the Korean Medicine Hospital
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background: Herbal medication is widely used in the Korean Medicine Hospital, and drug-induced liver injury (DILI) in Korea has increased proportionally. Herb-induced liver injury now accounts for approximately 40% of cases of hepatotoxicity in Korea, according to research data. Currently, however, the component responsible for the toxicity is usually unknown or can only be suspected. Objective: To study the hepatotoxicity of Cheongsimyeonja-tang in DILI. Methods: A retrospective review was conducted of 82 inpatients between April 2010 and March 2017 with suspected drug-induced liver injury (n=5). The standard criteria (RUCAM scale) for drug-induced liver injury (DILI) were applied. The electronic medical records (EMRs) were retrospectively reviewed to identify the relevant database. Aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin (T. Bili) were analyzed in blood samples before and after the administration of Cheongsimyeonja-tang. Results: Five cases out of 82 patients had a criterion-referenced probable (RUCAM) score ranging from 6 to 8 points DILI. However, statistical analysis of the liver function parameters results of the 82 patients did not show a statistically meaningful elevation after taking Cheongsimyeonja-tang. Conclusions: These data suggest a relationship between Cheongsimyeonja-tang and DILI. More studies are needed to validate these observations and to explore their implications.
Abstract
Background: Herbal medication is widely used in the Korean Medicine Hospital, and drug-induced liver injury (DILI) in Korea has increased proportionally. Herb-induced liver injury now accounts for approximately 40% of cases of hepatotoxicity in Korea, according to research data. Currently, however, the component responsible for the toxicity is usually unknown or can only be suspected. Objective: To study the hepatotoxicity of Cheongsimyeonja-tang in DILI. Methods: A retrospective review was conducted of 82 inpatients between April 2010 and March 2017 with suspected drug-induced liver injury (n=5). The standard criteria (RUCAM scale) for drug-induced liver injury (DILI) were applied. The electronic medical records (EMRs) were retrospectively reviewed to identify the relevant database. Aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin (T. Bili) were analyzed in blood samples before and after the administration of Cheongsimyeonja-tang. Results: Five cases out of 82 patients had a criterion-referenced probable (RUCAM) score ranging from 6 to 8 points DILI. However, statistical analysis of the liver function parameters results of the 82 patients did not show a statistically meaningful elevation after taking Cheongsimyeonja-tang. Conclusions: These data suggest a relationship between Cheongsimyeonja-tang and DILI. More studies are needed to validate these observations and to explore their implications.
참고문헌 (17)
- Ki TS, "A Prospective Nationwide Study of Drug-Induced Liver Injury in Korea", The American Journal of Gastroenterology, 107(9), pp.1380~1387 (2012)
- 김동준, "독성 간손상의 평가", 대한소화기학회지, 53(1), pp.5~14 (2009), 대한소화기학회
- Dufour DR, "Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests", Clin Chem, 46(12), pp.2027~2049 (2000)
- 안다영, "청심연자탕의 연구 동향", 사상체질의학회지, 30(3), pp.1~23 (2018), 사상체질의학회[DOI]
- 진성은, "열다한소탕과 청심연자탕의 Cytochrome P450 활성 연구", 사상체질의학회지, 24(4), pp.84~91 (2012), 사상체질의학회[DOI]
- 마진열, "Mouse에 있어서 시험물질 淸心蓮子湯 추출액의 급성독성 시험", 사상체질의학회지, 22(1), pp.59~65 (2010), 사상체질의학회
- 김영중, "Quatification of Flavonoid Contents in Chungsimyeonja-tang, a Multi-Herbal Decoction, and Its Protective Effect against Cisplatin-induced Nephrotoxicity", Natural Product Sciences, 20(4), pp.251~257 (2014), 한국생약학회
- 서창섭, "중금속, 잔류농약 및 잔류이산화황의 전탕 전, 후의 농도 변화 - 다빈도 태음인 사상처방을 중심으로 -", 사상체질의학회지, 21(1), pp.237~246 (2009), 사상체질의학회
- Bethesda, "RUCAM Manual of operations. Drug-induced liver injury: Standardization of Nomenclature and causality Assessment", NIH Workshop 2008 (2008)
- Yoon YK, "A Clinical Study about Capability of hepatotoxicity asssociated with Chungsim yeonjatang", Korean J Orient Int Med, 24(4), pp.792~795 (2003)
- Kim TS, "The Effects of Use of Sasang-Bang with Western Medicine on Liver and Kidney Function", J of Sasang Constitutional Medicine, 16(3), pp.70~75 (2004)
- Bog CH, "Diagnostic Criteria for Drug-Induced Liver Disease. Clinical and Molecular Hepatology", The Korean Association for the Study of the Liver, 7~18 (2004)
- 한덕진, "간기능 정상자 또는 불특정 환자를 대상으로 한 한약 복용 후 간기능 지표 변화에 대한 문헌적 고찰", 동의생리병리학회지, 22(6), pp.1390~1396 (2008), 한의병리학회
- Velayudham LS, "Drug-induced cholestasis", Expert Opin Drug Saf, 2(3), pp.287~304 (2003)
- Fishman WH, "Alkaline phosphatase isoenzyme : recent progress", Clin Biochem, 23(2), pp.90~104 (1990)
- Kim DY, "Liver function test", Korean J Intern Med, 29(2), pp.5~6 (2014)
- 안소연, "약인성 간손상 환자에 대한 生肝湯 치험 1례", 대한한방내과학회지, 40(2), pp.201~207 (2019), 대한한방내과학회[DOI]